Exploring the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder, and major depressive disorder
Abstract Background Uric acid plays a pivotal role in the regulation of mood and behavior. The study aimed to elucidate the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder (BAD), and major depressive disorder (MDD) and to examine its relation to symp...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-04-01
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| Series: | Middle East Current Psychiatry |
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| Online Access: | https://doi.org/10.1186/s43045-023-00307-3 |
| _version_ | 1797850233457082368 |
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| author | Nermin Mahmoud Shaker Doha el Serafi Riham Hossam E. L.-Din Mahfouz Mohamed Hossam El-din abd el moneam |
| author_facet | Nermin Mahmoud Shaker Doha el Serafi Riham Hossam E. L.-Din Mahfouz Mohamed Hossam El-din abd el moneam |
| author_sort | Nermin Mahmoud Shaker |
| collection | DOAJ |
| description | Abstract Background Uric acid plays a pivotal role in the regulation of mood and behavior. The study aimed to elucidate the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder (BAD), and major depressive disorder (MDD) and to examine its relation to symptom domains and severity of illness. Results A total of 150 participants with schizophrenia, BAD, and MDD and 50 healthy controls were recruited. Patients were assessed using Structured Clinical Interview for DSM-IV Axis I Diagnosis (SCID-I), Positive and Negative Syndrome Scale (PANSS), the Young Mania Rating Scale (YMRS), and the Hamilton Depression Rating Scale (HAM-D). General Health Questionnaire (GHQ-28) was applied to healthy controls. Then, a blood draw from all participants was performed to measure serum uric acid level. According to this study, there was a statistically significant difference between patients with schizophrenia, BAD, MDD, and healthy controls, with regard to serum uric acid level (P = 0.007). On correlating symptom domains and severity of schizophrenia, bipolar, and MDD with serum uric acid level, there was only a statistically significant negative correlation between YMRS and serum uric acid level (P = 0.022). Conclusions Serum uric acid could be a valuable biomarker in patients with schizophrenia, bipolar, and MDD especially in patients with bipolar disorder. |
| first_indexed | 2024-04-09T18:57:06Z |
| format | Article |
| id | doaj.art-6f235e23b4ca41fb887462997f2fb2fb |
| institution | Directory Open Access Journal |
| issn | 2090-5416 |
| language | English |
| last_indexed | 2024-04-09T18:57:06Z |
| publishDate | 2023-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Current Psychiatry |
| spelling | doaj.art-6f235e23b4ca41fb887462997f2fb2fb2023-04-09T11:06:55ZengSpringerOpenMiddle East Current Psychiatry2090-54162023-04-013011810.1186/s43045-023-00307-3Exploring the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder, and major depressive disorderNermin Mahmoud Shaker0Doha el Serafi1Riham Hossam E. L.-Din Mahfouz2Mohamed Hossam El-din abd el moneam3Okasha Institute of Psychiatry, Ain Shams UniversityOkasha Institute of Psychiatry, Ain Shams UniversityOkasha Institute of Psychiatry, Ain Shams UniversityOkasha Institute of Psychiatry, Ain Shams UniversityAbstract Background Uric acid plays a pivotal role in the regulation of mood and behavior. The study aimed to elucidate the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder (BAD), and major depressive disorder (MDD) and to examine its relation to symptom domains and severity of illness. Results A total of 150 participants with schizophrenia, BAD, and MDD and 50 healthy controls were recruited. Patients were assessed using Structured Clinical Interview for DSM-IV Axis I Diagnosis (SCID-I), Positive and Negative Syndrome Scale (PANSS), the Young Mania Rating Scale (YMRS), and the Hamilton Depression Rating Scale (HAM-D). General Health Questionnaire (GHQ-28) was applied to healthy controls. Then, a blood draw from all participants was performed to measure serum uric acid level. According to this study, there was a statistically significant difference between patients with schizophrenia, BAD, MDD, and healthy controls, with regard to serum uric acid level (P = 0.007). On correlating symptom domains and severity of schizophrenia, bipolar, and MDD with serum uric acid level, there was only a statistically significant negative correlation between YMRS and serum uric acid level (P = 0.022). Conclusions Serum uric acid could be a valuable biomarker in patients with schizophrenia, bipolar, and MDD especially in patients with bipolar disorder.https://doi.org/10.1186/s43045-023-00307-3Serum uric acidSchizophreniaBipolarMajor depressive disorderBiomarkerPurinergic pathway |
| spellingShingle | Nermin Mahmoud Shaker Doha el Serafi Riham Hossam E. L.-Din Mahfouz Mohamed Hossam El-din abd el moneam Exploring the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder, and major depressive disorder Middle East Current Psychiatry Serum uric acid Schizophrenia Bipolar Major depressive disorder Biomarker Purinergic pathway |
| title | Exploring the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder, and major depressive disorder |
| title_full | Exploring the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder, and major depressive disorder |
| title_fullStr | Exploring the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder, and major depressive disorder |
| title_full_unstemmed | Exploring the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder, and major depressive disorder |
| title_short | Exploring the role of serum uric acid as a biomarker in patients with schizophrenia, bipolar affective disorder, and major depressive disorder |
| title_sort | exploring the role of serum uric acid as a biomarker in patients with schizophrenia bipolar affective disorder and major depressive disorder |
| topic | Serum uric acid Schizophrenia Bipolar Major depressive disorder Biomarker Purinergic pathway |
| url | https://doi.org/10.1186/s43045-023-00307-3 |
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