Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway

Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway

Punicalagin, which is derived from pomegranate peel, is reported to exert growth-inhibitory effects against various cancers. However, the underlying mechanisms have not been elucidated. Human papillomavirus (HPV), a major oncovirus, utilizes the host autophagic machinery to support its replication....

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Bibliographic Details
Main Authors: Xialin Xie, Liuyi Hu, Lulu Liu, Jiuru Wang, Yongai Liu, Li Ma, Guangying Sun, Changfei Li, Haji Akber Aisa, Songdong Meng
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Translational Oncology
Subjects:
Punicalagin
E6
E7
Cervical cancer
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S193652332200050X

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