Sonchus arvensis L. water extract attenuates dextran sulfate sodium-induced colitis by adjusting gut microbiota
Sonchus arvensisL. (SA) is a traditional Chinese food and medicine termed “Ju Mai Cai”. The aim of this study was to investigate the protective effects of an aqueous extract of SA on dextran sulfate sodium (DSS) - induced colitis in mice by adjusting the diversity of gut microbiota. Male C57BL/6 mic...
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Elsevier
2023-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023013750 |
| _version_ | 1797851853580402688 |
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| author | Yachao Ren Shenghua Hou Yilei Sui Naidan Chang Yulong Zhou Changhao Sun |
| author_facet | Yachao Ren Shenghua Hou Yilei Sui Naidan Chang Yulong Zhou Changhao Sun |
| author_sort | Yachao Ren |
| collection | DOAJ |
| description | Sonchus arvensisL. (SA) is a traditional Chinese food and medicine termed “Ju Mai Cai”. The aim of this study was to investigate the protective effects of an aqueous extract of SA on dextran sulfate sodium (DSS) - induced colitis in mice by adjusting the diversity of gut microbiota. Male C57BL/6 mice were randomly divided into four groups: CL (control group); ML group (DSS only); SA group (SA extract); and MS group (SA extract + DSS). The protective effect of SA on ulcerative disease was estimated by several analyses (i.e., body weight loss, diarrhea, bloody stools, disease activity index scores, and hematoxylin and eosin staining). The effect of SA on gut microbiota was determined by analysis of the 16S ribosomal RNA gene sequences. The results indicated that MS significantly attenuated the body weight loss. The disease activity index scores were markedly lower in the MS group versus in the ML group. Moreover, the length of the colon was significantly improved in the MS groups versus in the ML group. Pathological changes were markedly improved following the administration of SA to mice with DSS-induced ulcerative disease. The results of Beta diversity analysis revealed that the composition of gut microbiota was significantly different between groups. Taken together, the results indicated that SA extract may prevent ulcerative colitis. |
| first_indexed | 2024-04-09T19:24:32Z |
| format | Article |
| id | doaj.art-6f2599fdd9d245a9bcaaba4e8530aaac |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:24:32Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-6f2599fdd9d245a9bcaaba4e8530aaac2023-04-05T08:21:06ZengElsevierHeliyon2405-84402023-03-0193e14168Sonchus arvensis L. water extract attenuates dextran sulfate sodium-induced colitis by adjusting gut microbiotaYachao Ren0Shenghua Hou1Yilei Sui2Naidan Chang3Yulong Zhou4Changhao Sun5School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, 300000, China; Harbin Medical University-Daqing, Daqing 163319, China; Corresponding author. School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, 300000, China.Harbin Medical University-Daqing, Daqing 163319, ChinaHarbin Medical University-Daqing, Daqing 163319, ChinaHarbin Medical University-Daqing, Daqing 163319, ChinaCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China; Corresponding author. College of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, ChinaHarbin Medical University, Harbin 150081, China; Corresponding author. Harbin Medical University, Harbin 150081, ChinaSonchus arvensisL. (SA) is a traditional Chinese food and medicine termed “Ju Mai Cai”. The aim of this study was to investigate the protective effects of an aqueous extract of SA on dextran sulfate sodium (DSS) - induced colitis in mice by adjusting the diversity of gut microbiota. Male C57BL/6 mice were randomly divided into four groups: CL (control group); ML group (DSS only); SA group (SA extract); and MS group (SA extract + DSS). The protective effect of SA on ulcerative disease was estimated by several analyses (i.e., body weight loss, diarrhea, bloody stools, disease activity index scores, and hematoxylin and eosin staining). The effect of SA on gut microbiota was determined by analysis of the 16S ribosomal RNA gene sequences. The results indicated that MS significantly attenuated the body weight loss. The disease activity index scores were markedly lower in the MS group versus in the ML group. Moreover, the length of the colon was significantly improved in the MS groups versus in the ML group. Pathological changes were markedly improved following the administration of SA to mice with DSS-induced ulcerative disease. The results of Beta diversity analysis revealed that the composition of gut microbiota was significantly different between groups. Taken together, the results indicated that SA extract may prevent ulcerative colitis.http://www.sciencedirect.com/science/article/pii/S2405844023013750Sonchus arvensis L.Ulcerative colitisGut microbiotaDextran sulfate sodiumTraditional Chinese medicine |
| spellingShingle | Yachao Ren Shenghua Hou Yilei Sui Naidan Chang Yulong Zhou Changhao Sun Sonchus arvensis L. water extract attenuates dextran sulfate sodium-induced colitis by adjusting gut microbiota Heliyon Sonchus arvensis L. Ulcerative colitis Gut microbiota Dextran sulfate sodium Traditional Chinese medicine |
| title | Sonchus arvensis L. water extract attenuates dextran sulfate sodium-induced colitis by adjusting gut microbiota |
| title_full | Sonchus arvensis L. water extract attenuates dextran sulfate sodium-induced colitis by adjusting gut microbiota |
| title_fullStr | Sonchus arvensis L. water extract attenuates dextran sulfate sodium-induced colitis by adjusting gut microbiota |
| title_full_unstemmed | Sonchus arvensis L. water extract attenuates dextran sulfate sodium-induced colitis by adjusting gut microbiota |
| title_short | Sonchus arvensis L. water extract attenuates dextran sulfate sodium-induced colitis by adjusting gut microbiota |
| title_sort | sonchus arvensis l water extract attenuates dextran sulfate sodium induced colitis by adjusting gut microbiota |
| topic | Sonchus arvensis L. Ulcerative colitis Gut microbiota Dextran sulfate sodium Traditional Chinese medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023013750 |
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