Autologous Skin Fibroblast‐Based PLGA Nanoparticles for Treating Multiorgan Fibrosis

Autologous Skin Fibroblast‐Based PLGA Nanoparticles for Treating Multiorgan Fibrosis

Abstract Fibrotic diseases remain a substantial health burden with few therapeutic approaches. A hallmark of fibrosis is the aberrant activation and accumulation of myofibroblasts, which is caused by excessive profibrotic cytokines. Conventional anticytokine therapies fail to undergo clinical trials...

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Bibliographic Details
Main Authors: Qiang Long, Zehua Liu, Qianwen Shao, Hongpeng Shi, Shixing Huang, Chenyu Jiang, Bei Qian, Yiming Zhong, Xiaojun He, Xiaogang Xiang, Yang Yang, Bing Li, Xiaoxiang Yan, Qiang Zhao, Xiaoli Wei, Hélder A. Santos, Xiaofeng Ye
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Advanced Science
Subjects:
fibrosis
myofibroblast
nanoparticles
profibrotic cytokine
Online Access:https://doi.org/10.1002/advs.202200856

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