Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection
<p>Abstract</p> <p>With the continuing march of the AIDS epidemic and little hope for an effective vaccine in the near future, work to develop a topical strategy to prevent HIV infection is increasingly important. This stated, the track record of large scale "microbicide"...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-12-01
|
| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/5/1/116 |
| _version_ | 1811252818023022592 |
|---|---|
| author | Root Michael Pilch-Cooper Heather A Jump Robin Lederman Michael M Sieg Scott F |
| author_facet | Root Michael Pilch-Cooper Heather A Jump Robin Lederman Michael M Sieg Scott F |
| author_sort | Root Michael |
| collection | DOAJ |
| description | <p>Abstract</p> <p>With the continuing march of the AIDS epidemic and little hope for an effective vaccine in the near future, work to develop a topical strategy to prevent HIV infection is increasingly important. This stated, the track record of large scale "microbicide" trials has been disappointing with nonspecific inhibitors either failing to protect women from infection or even increasing HIV acquisition. Newer strategies that target directly the elements needed for viral entry into cells have shown promise in non-human primate models of HIV transmission and as these agents have not yet been broadly introduced in regions of highest HIV prevalence, they are particularly attractive for prophylaxis. We review here the agents that can block HIV cellular entry and that show promise as topical strategies or "virustats" to prevent mucosal transmission of HIV infection</p> |
| first_indexed | 2024-04-12T16:40:28Z |
| format | Article |
| id | doaj.art-6f2ba6d08a12421f8face9192d0cfa7c |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-04-12T16:40:28Z |
| publishDate | 2008-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-6f2ba6d08a12421f8face9192d0cfa7c2022-12-22T03:24:48ZengBMCRetrovirology1742-46902008-12-015111610.1186/1742-4690-5-116Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infectionRoot MichaelPilch-Cooper Heather AJump RobinLederman Michael MSieg Scott F<p>Abstract</p> <p>With the continuing march of the AIDS epidemic and little hope for an effective vaccine in the near future, work to develop a topical strategy to prevent HIV infection is increasingly important. This stated, the track record of large scale "microbicide" trials has been disappointing with nonspecific inhibitors either failing to protect women from infection or even increasing HIV acquisition. Newer strategies that target directly the elements needed for viral entry into cells have shown promise in non-human primate models of HIV transmission and as these agents have not yet been broadly introduced in regions of highest HIV prevalence, they are particularly attractive for prophylaxis. We review here the agents that can block HIV cellular entry and that show promise as topical strategies or "virustats" to prevent mucosal transmission of HIV infection</p>http://www.retrovirology.com/content/5/1/116 |
| spellingShingle | Root Michael Pilch-Cooper Heather A Jump Robin Lederman Michael M Sieg Scott F Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection Retrovirology |
| title | Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection |
| title_full | Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection |
| title_fullStr | Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection |
| title_full_unstemmed | Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection |
| title_short | Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection |
| title_sort | topical application of entry inhibitors as virustats to prevent sexual transmission of hiv infection |
| url | http://www.retrovirology.com/content/5/1/116 |
| work_keys_str_mv | AT rootmichael topicalapplicationofentryinhibitorsasvirustatstopreventsexualtransmissionofhivinfection AT pilchcooperheathera topicalapplicationofentryinhibitorsasvirustatstopreventsexualtransmissionofhivinfection AT jumprobin topicalapplicationofentryinhibitorsasvirustatstopreventsexualtransmissionofhivinfection AT ledermanmichaelm topicalapplicationofentryinhibitorsasvirustatstopreventsexualtransmissionofhivinfection AT siegscottf topicalapplicationofentryinhibitorsasvirustatstopreventsexualtransmissionofhivinfection |