BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery

BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery

ABSTRACT The 3C-like protease (3CLpro) of SARS-CoV-2 is an attractive drug target for developing antivirals against SARS-CoV-2. A few small molecule inhibitors of 3CLpro are in clinical trials for COVID-19 treatments, and more inhibitors are under development. One limiting factor for 3CLpro inhibito...

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Bibliographic Details
Main Authors: Ningke Hou, Chen Peng, Lijing Zhang, Yuyao Zhu, Qi Hu
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
3C-like protease
BRET
SARS-CoV-2
inhibitor
self-cleaving biosensor
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02559-21

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