Spermidine/Spermine N1-Acetyltransferase 1 (<i>SAT1</i>)—A Potential Gene Target for Selective Sensitization of Glioblastoma Cells Using an Ionizable Lipid Nanoparticle to Deliver siRNA

Spermidine/Spermine N1-Acetyltransferase 1 (<i>SAT1</i>)—A Potential Gene Target for Selective Sensitization of Glioblastoma Cells Using an Ionizable Lipid Nanoparticle to Deliver siRNA

Spermidine/spermine N1-acetyltransferase 1 (<i>SAT1</i>) responsible for cell polyamine catabolism is overexpressed in glioblastoma multiforme (GB). Its role in tumor survival and promoting resistance towards radiation therapy has made it an interesting target for therapy. In this study,...

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Bibliographic Details
Main Authors: Vinith Yathindranath, Nura Safa, Babu V. Sajesh, Kelly Schwinghamer, Magimairajan Issai Vanan, Rashid Bux, Daniel S. Sitar, Marshall Pitz, Teruna J. Siahaan, Donald W. Miller
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
glioblastoma (GB)
Spermidine/spermine N1-acetyltransferase 1 (<i>SAT1</i>)
lipid nanoparticles
siRNA
microfluidic mixing
gene therapy
Online Access:https://www.mdpi.com/2072-6694/14/21/5179

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