Serum IFN-γ is increased in patients with active vitiligo
Objective To examine serum C-reactive protein (CRP), tumor necrosis factor-α(TNF-α), tumor necrosis factor-β(TNF-β), E-cadherin (E-cad), human interferon-γ (IFN-γ) and cluster of differentiation 8 (CD8) in patients with vitiligo. Methods From May 2017 to December 2018, 60 patients with vitiligo (30...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2022-07-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-7-1067.pdf |
| _version_ | 1797365857949581312 |
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| author | ZHAO Xiao-ling, HE Run-zhi, SUN Yu-jiao, ZHANG Xiao-chong, YANG Lin-fang, WANG Rui, CHENG Fang |
| author_facet | ZHAO Xiao-ling, HE Run-zhi, SUN Yu-jiao, ZHANG Xiao-chong, YANG Lin-fang, WANG Rui, CHENG Fang |
| author_sort | ZHAO Xiao-ling, HE Run-zhi, SUN Yu-jiao, ZHANG Xiao-chong, YANG Lin-fang, WANG Rui, CHENG Fang |
| collection | DOAJ |
| description | Objective To examine serum C-reactive protein (CRP), tumor necrosis factor-α(TNF-α), tumor necrosis factor-β(TNF-β), E-cadherin (E-cad), human interferon-γ (IFN-γ) and cluster of differentiation 8 (CD8) in patients with vitiligo. Methods From May 2017 to December 2018, 60 patients with vitiligo (30 cases in active phase group and 30 cases in stable stage group) and 30 cases as control group collected from physical examination center joined the research program. The content of serum CRP, TNF-α, TNF-β, E-cad, IFN-γ and CD8 were compared among the three groups by enzyme-linked immunosorbent assay (ELISA). Results The content of serum CRP, TNF-α, TNF-β and IFN-γ in patients with active and stable vitiligo were significantly higher(P＜0.05). The content of serum IFN-γ in patients with active vitiligo was significantly higher than that in patients with stable vitiligo(P＜0.05)and significantly decreased after 6 months of treatment(P＜0.05). Conclusions The content of serum IFN-γ might be used as a biomarker in laboratory to evaluate the activity of vitiligo. |
| first_indexed | 2024-03-08T16:55:54Z |
| format | Article |
| id | doaj.art-6f2d63d90bf94115a28e83d453d28a4c |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:55:54Z |
| publishDate | 2022-07-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-6f2d63d90bf94115a28e83d453d28a4c2024-01-05T02:35:59ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252022-07-014271067107010.16352/j.issn.1001-6325.2022.07.1067Serum IFN-γ is increased in patients with active vitiligoZHAO Xiao-ling, HE Run-zhi, SUN Yu-jiao, ZHANG Xiao-chong, YANG Lin-fang, WANG Rui, CHENG Fang01. Cancer Laboratory; 2. Department 3 of Neurosurgery; 3. Department of Dermatology; 4. Department of Scientific Research and Teaching, Xingtai People's Hospital Affiliated to Hebei Medical University, Xingtai 054001, ChinaObjective To examine serum C-reactive protein (CRP), tumor necrosis factor-α(TNF-α), tumor necrosis factor-β(TNF-β), E-cadherin (E-cad), human interferon-γ (IFN-γ) and cluster of differentiation 8 (CD8) in patients with vitiligo. Methods From May 2017 to December 2018, 60 patients with vitiligo (30 cases in active phase group and 30 cases in stable stage group) and 30 cases as control group collected from physical examination center joined the research program. The content of serum CRP, TNF-α, TNF-β, E-cad, IFN-γ and CD8 were compared among the three groups by enzyme-linked immunosorbent assay (ELISA). Results The content of serum CRP, TNF-α, TNF-β and IFN-γ in patients with active and stable vitiligo were significantly higher(P＜0.05). The content of serum IFN-γ in patients with active vitiligo was significantly higher than that in patients with stable vitiligo(P＜0.05)and significantly decreased after 6 months of treatment(P＜0.05). Conclusions The content of serum IFN-γ might be used as a biomarker in laboratory to evaluate the activity of vitiligo.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-7-1067.pdfvitiligo|cytokines|active stage|pathogenesis |
| spellingShingle | ZHAO Xiao-ling, HE Run-zhi, SUN Yu-jiao, ZHANG Xiao-chong, YANG Lin-fang, WANG Rui, CHENG Fang Serum IFN-γ is increased in patients with active vitiligo Jichu yixue yu linchuang vitiligo|cytokines|active stage|pathogenesis |
| title | Serum IFN-γ is increased in patients with active vitiligo |
| title_full | Serum IFN-γ is increased in patients with active vitiligo |
| title_fullStr | Serum IFN-γ is increased in patients with active vitiligo |
| title_full_unstemmed | Serum IFN-γ is increased in patients with active vitiligo |
| title_short | Serum IFN-γ is increased in patients with active vitiligo |
| title_sort | serum ifn γ is increased in patients with active vitiligo |
| topic | vitiligo|cytokines|active stage|pathogenesis |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-7-1067.pdf |
| work_keys_str_mv | AT zhaoxiaolingherunzhisunyujiaozhangxiaochongyanglinfangwangruichengfang serumifngisincreasedinpatientswithactivevitiligo |