Incidence of epileptiform EEG activity in children during mask induction of anaesthesia with brief administration of 8% sevoflurane.
BACKGROUND: A high incidence of epileptiform activity in the electroencephalogram (EEG) was reported in children undergoing mask induction of anaesthesia with administration of high doses of sevoflurane for 5 minutes and longer. This study was performed to investigate whether reducing the time of ex...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3400655?pdf=render |
| _version_ | 1819267045832785920 |
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| author | Barbara Schultz Christian Otto Arthur Schultz Wilhelm Alexander Osthaus Terence Krauss Thorben Dieck Björn Sander Niels Rahe-Meyer Konstantinos Raymondos |
| author_facet | Barbara Schultz Christian Otto Arthur Schultz Wilhelm Alexander Osthaus Terence Krauss Thorben Dieck Björn Sander Niels Rahe-Meyer Konstantinos Raymondos |
| author_sort | Barbara Schultz |
| collection | DOAJ |
| description | BACKGROUND: A high incidence of epileptiform activity in the electroencephalogram (EEG) was reported in children undergoing mask induction of anaesthesia with administration of high doses of sevoflurane for 5 minutes and longer. This study was performed to investigate whether reducing the time of exposure to a high inhaled sevoflurane concentration would affect the incidence of epileptiform EEG activity. It was hypothesized that no epileptiform activity would occur, when the inhaled sevoflurane concentration would be reduced from 8% to 4% immediately after the loss of consciousness. METHODOLOGY/PRINCIPAL FINDINGS: 70 children (age 7-96 months, ASA I-II, premedication with midazolam) were anaesthetized with 8% sevoflurane in 100% oxygen via face mask. Immediately after loss of consciousness, the sevoflurane concentration was reduced to 4%. EEGs were recorded continuously and were later analyzed visually with regard to epileptiform EEG patterns. Sevoflurane at a concentration of 8% was given for 1.2 ± 0.4 min (mean ± SD). In 14 children (20%) epileptiform EEG patterns without motor manifestations were observed (delta with spikes (DSP), rhythmic polyspikes (PSR), epileptiform discharges (PED) in 10, 10, 4 children (14%, 14%, 6%)). 38 children (54%) had slow, rhythmic delta waves with high amplitudes (DS) appearing on average before DSP. CONCLUSIONS/SIGNIFICANCE: The hypothesis that no epileptiform potentials would occur during induction of anaesthesia with a reduction of the inspired sevoflurane concentration from 8% to 4% directly after LOC was not proved. Even if 8% sevoflurane is administered only briefly for induction of anaesthesia, epileptiform EEG activity may be observed in children despite premedication with midazolam. |
| first_indexed | 2024-12-23T21:10:56Z |
| format | Article |
| id | doaj.art-6f2f3f6aa9b2400b8227d485b17c5b2f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T21:10:56Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6f2f3f6aa9b2400b8227d485b17c5b2f2022-12-21T17:31:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0177e4090310.1371/journal.pone.0040903Incidence of epileptiform EEG activity in children during mask induction of anaesthesia with brief administration of 8% sevoflurane.Barbara SchultzChristian OttoArthur SchultzWilhelm Alexander OsthausTerence KraussThorben DieckBjörn SanderNiels Rahe-MeyerKonstantinos RaymondosBACKGROUND: A high incidence of epileptiform activity in the electroencephalogram (EEG) was reported in children undergoing mask induction of anaesthesia with administration of high doses of sevoflurane for 5 minutes and longer. This study was performed to investigate whether reducing the time of exposure to a high inhaled sevoflurane concentration would affect the incidence of epileptiform EEG activity. It was hypothesized that no epileptiform activity would occur, when the inhaled sevoflurane concentration would be reduced from 8% to 4% immediately after the loss of consciousness. METHODOLOGY/PRINCIPAL FINDINGS: 70 children (age 7-96 months, ASA I-II, premedication with midazolam) were anaesthetized with 8% sevoflurane in 100% oxygen via face mask. Immediately after loss of consciousness, the sevoflurane concentration was reduced to 4%. EEGs were recorded continuously and were later analyzed visually with regard to epileptiform EEG patterns. Sevoflurane at a concentration of 8% was given for 1.2 ± 0.4 min (mean ± SD). In 14 children (20%) epileptiform EEG patterns without motor manifestations were observed (delta with spikes (DSP), rhythmic polyspikes (PSR), epileptiform discharges (PED) in 10, 10, 4 children (14%, 14%, 6%)). 38 children (54%) had slow, rhythmic delta waves with high amplitudes (DS) appearing on average before DSP. CONCLUSIONS/SIGNIFICANCE: The hypothesis that no epileptiform potentials would occur during induction of anaesthesia with a reduction of the inspired sevoflurane concentration from 8% to 4% directly after LOC was not proved. Even if 8% sevoflurane is administered only briefly for induction of anaesthesia, epileptiform EEG activity may be observed in children despite premedication with midazolam.http://europepmc.org/articles/PMC3400655?pdf=render |
| spellingShingle | Barbara Schultz Christian Otto Arthur Schultz Wilhelm Alexander Osthaus Terence Krauss Thorben Dieck Björn Sander Niels Rahe-Meyer Konstantinos Raymondos Incidence of epileptiform EEG activity in children during mask induction of anaesthesia with brief administration of 8% sevoflurane. PLoS ONE |
| title | Incidence of epileptiform EEG activity in children during mask induction of anaesthesia with brief administration of 8% sevoflurane. |
| title_full | Incidence of epileptiform EEG activity in children during mask induction of anaesthesia with brief administration of 8% sevoflurane. |
| title_fullStr | Incidence of epileptiform EEG activity in children during mask induction of anaesthesia with brief administration of 8% sevoflurane. |
| title_full_unstemmed | Incidence of epileptiform EEG activity in children during mask induction of anaesthesia with brief administration of 8% sevoflurane. |
| title_short | Incidence of epileptiform EEG activity in children during mask induction of anaesthesia with brief administration of 8% sevoflurane. |
| title_sort | incidence of epileptiform eeg activity in children during mask induction of anaesthesia with brief administration of 8 sevoflurane |
| url | http://europepmc.org/articles/PMC3400655?pdf=render |
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