INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS
The authors propose a new methodological approach to rapid intensity assessment of specific sensitization in acute brucellosis. This technique shows high sensitivity (98%), and specificity (97%). We revealed a direct relation between the intensity of specific IgE-dependent sensitization accompanied...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | Russian |
Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2016-08-01
|
Series: | Медицинская иммунология |
Subjects: | |
Online Access: | https://www.mimmun.ru/mimmun/article/view/1059 |
Summary: | The authors propose a new methodological approach to rapid intensity assessment of specific sensitization in acute brucellosis. This technique shows high sensitivity (98%), and specificity (97%). We revealed a direct relation between the intensity of specific IgE-dependent sensitization accompanied by development of immunosuppressive state in patients with brucellosis, i.e., a mean reduction of total CD3+ cell counts by 17.9%; CD3+CD4+ cells, by 13.3%; CD16+CD56+, by 4.4%. Phagocytic ability of blood neutrophils was decreased by 25.8%. The study has shown that an increased reagin-dependent sensitization in brucellosis is closely associated with emergence of severe immunosuppression. |
---|---|
ISSN: | 1563-0625 2313-741X |