(R)-albuterol decreases immune responses: role of activated T cells
<p>Abstract</p> <p>Racemic albuterol is an equimolar mixture of two isomers, (R) and (S). Whether (R) and (S) isomers and the combination of both exert different effects in immune activation is not well defined. We analyzed the effects of (R+S)-albuterol, (R)-albuterol and (S)-albu...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-01-01
|
| Series: | Respiratory Research |
| Online Access: | http://respiratory-research.com/content/9/1/3 |
| _version_ | 1818533559403544576 |
|---|---|
| author | Lu Xin He Hong Jen Kai Gordon Erin L Ferrada Marcela A Barone Leesa M Amirifeli Sepideh Perkins David L Finn Patricia W |
| author_facet | Lu Xin He Hong Jen Kai Gordon Erin L Ferrada Marcela A Barone Leesa M Amirifeli Sepideh Perkins David L Finn Patricia W |
| author_sort | Lu Xin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Racemic albuterol is an equimolar mixture of two isomers, (R) and (S). Whether (R) and (S) isomers and the combination of both exert different effects in immune activation is not well defined. We analyzed the effects of (R+S)-albuterol, (R)-albuterol and (S)-albuterol in a murine model of allergic pulmonary inflammation and in activated T cells. Mice (C57BL/6) sensitized and aerosol challenged with the allergen ovalbumin (OVA) or phosphate buffered saline (PBS) were treated with (R)-albuterol, (S)-albuterol or (R+S)-albuterol. Following administration of (R)-albuterol, allergen induced bronchoalveolar lavage eosinophils and IgE showed a decrease, albeit not significantly by ANOVA. As T cells are important in allergic inflammation, we asked whether (R+S), (R) or (S)-albuterol might differ in effects on T cells and on the activity of the inflammatory transcription factor NF-κB. In activated T cells, (R)-albuterol administration decreased levels of inflammatory cytokines and NF-κB activity. These studies suggest that (R)-albuterol decreases cytokine secretion and NF-κB activity in T cells.</p> |
| first_indexed | 2024-12-11T18:00:19Z |
| format | Article |
| id | doaj.art-6f322e6d2edf48158108c9e0e77c45a0 |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-11T18:00:19Z |
| publishDate | 2008-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-6f322e6d2edf48158108c9e0e77c45a02022-12-22T00:55:54ZengBMCRespiratory Research1465-99212008-01-0191310.1186/1465-9921-9-3(R)-albuterol decreases immune responses: role of activated T cellsLu XinHe HongJen KaiGordon Erin LFerrada Marcela ABarone Leesa MAmirifeli SepidehPerkins David LFinn Patricia W<p>Abstract</p> <p>Racemic albuterol is an equimolar mixture of two isomers, (R) and (S). Whether (R) and (S) isomers and the combination of both exert different effects in immune activation is not well defined. We analyzed the effects of (R+S)-albuterol, (R)-albuterol and (S)-albuterol in a murine model of allergic pulmonary inflammation and in activated T cells. Mice (C57BL/6) sensitized and aerosol challenged with the allergen ovalbumin (OVA) or phosphate buffered saline (PBS) were treated with (R)-albuterol, (S)-albuterol or (R+S)-albuterol. Following administration of (R)-albuterol, allergen induced bronchoalveolar lavage eosinophils and IgE showed a decrease, albeit not significantly by ANOVA. As T cells are important in allergic inflammation, we asked whether (R+S), (R) or (S)-albuterol might differ in effects on T cells and on the activity of the inflammatory transcription factor NF-κB. In activated T cells, (R)-albuterol administration decreased levels of inflammatory cytokines and NF-κB activity. These studies suggest that (R)-albuterol decreases cytokine secretion and NF-κB activity in T cells.</p>http://respiratory-research.com/content/9/1/3 |
| spellingShingle | Lu Xin He Hong Jen Kai Gordon Erin L Ferrada Marcela A Barone Leesa M Amirifeli Sepideh Perkins David L Finn Patricia W (R)-albuterol decreases immune responses: role of activated T cells Respiratory Research |
| title | (R)-albuterol decreases immune responses: role of activated T cells |
| title_full | (R)-albuterol decreases immune responses: role of activated T cells |
| title_fullStr | (R)-albuterol decreases immune responses: role of activated T cells |
| title_full_unstemmed | (R)-albuterol decreases immune responses: role of activated T cells |
| title_short | (R)-albuterol decreases immune responses: role of activated T cells |
| title_sort | r albuterol decreases immune responses role of activated t cells |
| url | http://respiratory-research.com/content/9/1/3 |
| work_keys_str_mv | AT luxin ralbuteroldecreasesimmuneresponsesroleofactivatedtcells AT hehong ralbuteroldecreasesimmuneresponsesroleofactivatedtcells AT jenkai ralbuteroldecreasesimmuneresponsesroleofactivatedtcells AT gordonerinl ralbuteroldecreasesimmuneresponsesroleofactivatedtcells AT ferradamarcelaa ralbuteroldecreasesimmuneresponsesroleofactivatedtcells AT baroneleesam ralbuteroldecreasesimmuneresponsesroleofactivatedtcells AT amirifelisepideh ralbuteroldecreasesimmuneresponsesroleofactivatedtcells AT perkinsdavidl ralbuteroldecreasesimmuneresponsesroleofactivatedtcells AT finnpatriciaw ralbuteroldecreasesimmuneresponsesroleofactivatedtcells |