A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamics
The hippocampal subfields, pivotal to episodic memory, are distinct both in terms of cyto- and myeloarchitectony. Studying the structure of hippocampal subfields in vivo is crucial to understand volumetric trajectories across the lifespan, from the emergence of episodic memory during early childhood...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neuroinformatics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fninf.2023.1130845/full |
| _version_ | 1797803995789524992 |
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| author | Clement Poiret Clement Poiret Clement Poiret Antoine Bouyeure Antoine Bouyeure Antoine Bouyeure Sandesh Patil Sandesh Patil Sandesh Patil Antoine Grigis Antoine Grigis Edouard Duchesnay Edouard Duchesnay Matthieu Faillot Matthieu Faillot Michel Bottlaender Michel Bottlaender Frederic Lemaitre Frederic Lemaitre Marion Noulhiane Marion Noulhiane Marion Noulhiane |
| author_facet | Clement Poiret Clement Poiret Clement Poiret Antoine Bouyeure Antoine Bouyeure Antoine Bouyeure Sandesh Patil Sandesh Patil Sandesh Patil Antoine Grigis Antoine Grigis Edouard Duchesnay Edouard Duchesnay Matthieu Faillot Matthieu Faillot Michel Bottlaender Michel Bottlaender Frederic Lemaitre Frederic Lemaitre Marion Noulhiane Marion Noulhiane Marion Noulhiane |
| author_sort | Clement Poiret |
| collection | DOAJ |
| description | The hippocampal subfields, pivotal to episodic memory, are distinct both in terms of cyto- and myeloarchitectony. Studying the structure of hippocampal subfields in vivo is crucial to understand volumetric trajectories across the lifespan, from the emergence of episodic memory during early childhood to memory impairments found in older adults. However, segmenting hippocampal subfields on conventional MRI sequences is challenging because of their small size. Furthermore, there is to date no unified segmentation protocol for the hippocampal subfields, which limits comparisons between studies. Therefore, we introduced a novel segmentation tool called HSF short for hippocampal segmentation factory, which leverages an end-to-end deep learning pipeline. First, we validated HSF against currently used tools (ASHS, HIPS, and HippUnfold). Then, we used HSF on 3,750 subjects from the HCP development, young adults, and aging datasets to study the effect of age and sex on hippocampal subfields volumes. Firstly, we showed HSF to be closer to manual segmentation than other currently used tools (p < 0.001), regarding the Dice Coefficient, Hausdorff Distance, and Volumetric Similarity. Then, we showed differential maturation and aging across subfields, with the dentate gyrus being the most affected by age. We also found faster growth and decay in men than in women for most hippocampal subfields. Thus, while we introduced a new, fast and robust end-to-end segmentation tool, our neuroanatomical results concerning the lifespan trajectories of the hippocampal subfields reconcile previous conflicting results. |
| first_indexed | 2024-03-13T05:30:28Z |
| format | Article |
| id | doaj.art-6f33c2cfc3e6437d80307ae254e0b28c |
| institution | Directory Open Access Journal |
| issn | 1662-5196 |
| language | English |
| last_indexed | 2024-03-13T05:30:28Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroinformatics |
| spelling | doaj.art-6f33c2cfc3e6437d80307ae254e0b28c2023-06-15T04:46:56ZengFrontiers Media S.A.Frontiers in Neuroinformatics1662-51962023-06-011710.3389/fninf.2023.11308451130845A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamicsClement Poiret0Clement Poiret1Clement Poiret2Antoine Bouyeure3Antoine Bouyeure4Antoine Bouyeure5Sandesh Patil6Sandesh Patil7Sandesh Patil8Antoine Grigis9Antoine Grigis10Edouard Duchesnay11Edouard Duchesnay12Matthieu Faillot13Matthieu Faillot14Michel Bottlaender15Michel Bottlaender16Frederic Lemaitre17Frederic Lemaitre18Marion Noulhiane19Marion Noulhiane20Marion Noulhiane21UNIACT, NeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceNeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceInDEV, NeuroDiderot, Université Paris Cité, Inserm, Paris, FranceUNIACT, NeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceNeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceInDEV, NeuroDiderot, Université Paris Cité, Inserm, Paris, FranceUNIACT, NeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceNeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceInDEV, NeuroDiderot, Université Paris Cité, Inserm, Paris, FranceNeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceInDEV, NeuroDiderot, Université Paris Cité, Inserm, Paris, FranceNeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceInDEV, NeuroDiderot, Université Paris Cité, Inserm, Paris, FranceNeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceBioMaps, Service Hospitalier Frédéric Joliot, CNRS, Inserm, Université Paris-Saclay, Orsay, FranceNeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceBioMaps, Service Hospitalier Frédéric Joliot, CNRS, Inserm, Université Paris-Saclay, Orsay, FranceCETAPS EA 3832, Université de Rouen, Rouen, FranceCRIOBE, UAR 3278, CNRS-EPHE-UPVD, Mooréa, FranceUNIACT, NeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceNeuroSpin, CEA Paris-Saclay, Frederic Joliot Institute, Gif-sur-Yvette, FranceInDEV, NeuroDiderot, Université Paris Cité, Inserm, Paris, FranceThe hippocampal subfields, pivotal to episodic memory, are distinct both in terms of cyto- and myeloarchitectony. Studying the structure of hippocampal subfields in vivo is crucial to understand volumetric trajectories across the lifespan, from the emergence of episodic memory during early childhood to memory impairments found in older adults. However, segmenting hippocampal subfields on conventional MRI sequences is challenging because of their small size. Furthermore, there is to date no unified segmentation protocol for the hippocampal subfields, which limits comparisons between studies. Therefore, we introduced a novel segmentation tool called HSF short for hippocampal segmentation factory, which leverages an end-to-end deep learning pipeline. First, we validated HSF against currently used tools (ASHS, HIPS, and HippUnfold). Then, we used HSF on 3,750 subjects from the HCP development, young adults, and aging datasets to study the effect of age and sex on hippocampal subfields volumes. Firstly, we showed HSF to be closer to manual segmentation than other currently used tools (p < 0.001), regarding the Dice Coefficient, Hausdorff Distance, and Volumetric Similarity. Then, we showed differential maturation and aging across subfields, with the dentate gyrus being the most affected by age. We also found faster growth and decay in men than in women for most hippocampal subfields. Thus, while we introduced a new, fast and robust end-to-end segmentation tool, our neuroanatomical results concerning the lifespan trajectories of the hippocampal subfields reconcile previous conflicting results.https://www.frontiersin.org/articles/10.3389/fninf.2023.1130845/fulldeep learningsemantic segmentationMRIdevelopmentaging |
| spellingShingle | Clement Poiret Clement Poiret Clement Poiret Antoine Bouyeure Antoine Bouyeure Antoine Bouyeure Sandesh Patil Sandesh Patil Sandesh Patil Antoine Grigis Antoine Grigis Edouard Duchesnay Edouard Duchesnay Matthieu Faillot Matthieu Faillot Michel Bottlaender Michel Bottlaender Frederic Lemaitre Frederic Lemaitre Marion Noulhiane Marion Noulhiane Marion Noulhiane A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamics Frontiers in Neuroinformatics deep learning semantic segmentation MRI development aging |
| title | A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamics |
| title_full | A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamics |
| title_fullStr | A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamics |
| title_full_unstemmed | A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamics |
| title_short | A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamics |
| title_sort | fast and robust hippocampal subfields segmentation hsf revealing lifespan volumetric dynamics |
| topic | deep learning semantic segmentation MRI development aging |
| url | https://www.frontiersin.org/articles/10.3389/fninf.2023.1130845/full |
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