Polydatin Prevents Lipopolysaccharide (LPS)-Induced Parkinson's Disease via Regulation of the AKT/GSK3β-Nrf2/NF-κB Signaling Axis

Polydatin Prevents Lipopolysaccharide (LPS)-Induced Parkinson's Disease via Regulation of the AKT/GSK3β-Nrf2/NF-κB Signaling Axis

Parkinson's disease (PD) is a common neurodegenerative disease characterized by selective loss of dopaminergic neurons in the substantia nigra (SN). Neuroinflammation induced by over-activation of microglia leads to the death of dopaminergic neurons in the pathogenesis of PD. Therefore, downreg...

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Bibliographic Details
Main Authors: Bingxu Huang, Juxiong Liu, Tianyu Meng, Yuhang Li, Dewei He, Xin Ran, Guangxin Chen, Wenjin Guo, Xingchi Kan, Shoupeng Fu, Wei Wang, Dianfeng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
parkinson's disease
neuroinflammation
polydatin
microglia
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02527/full

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