Antimicrobial Peptides from Black Soldier Fly (<i>Hermetia illucens</i>) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming
Functional antimicrobial peptides (AMPs) are an important class of effector molecules of innate host immune defense against pathogen invasion. Inability of microorganisms to develop resistance against the majority of AMPs has made them alternatives to antibiotics, contributing to the development of...
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MDPI AG
2021-06-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/7/1937 |
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| author | Jing Xia Chaorong Ge Huaiying Yao |
| author_facet | Jing Xia Chaorong Ge Huaiying Yao |
| author_sort | Jing Xia |
| collection | DOAJ |
| description | Functional antimicrobial peptides (AMPs) are an important class of effector molecules of innate host immune defense against pathogen invasion. Inability of microorganisms to develop resistance against the majority of AMPs has made them alternatives to antibiotics, contributing to the development of a new generation of antimicrobials. Due to extensive biodiversity, insects are one of the most abundant sources of novel AMPs. Notably, black soldier fly insect (BSF; <i>Hermetia illucens</i> (Diptera: Stratiomyidae)) feeds on decaying substrates and displays a supernormal capacity to survive under adverse conditions in the presence of abundant microorganisms, therefore, BSF is one of the most promising sources for identification of AMPs. However, discovery, functional investigation, and drug development to replace antibiotics with AMPs from <i>Hermetia illucens</i> remain in a preliminary stage. In this review, we provide general information on currently verified AMPs of <i>Hermetia illucens</i>, describe their potential medical value, discuss the mechanism of their synthesis and interactions, and consider the development of bacterial resistance to AMPs in comparison with antibiotics, aiming to provide a candidate for substitution of antibiotics in livestock farming or, to some extent, for blocking the horizontal transfer of resistance genes in the environment, which is beneficial to human and animal welfare. |
| first_indexed | 2024-03-10T09:57:47Z |
| format | Article |
| id | doaj.art-6f359af23e08447ca6f6346a032acf3b |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T09:57:47Z |
| publishDate | 2021-06-01 |
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| record_format | Article |
| series | Animals |
| spelling | doaj.art-6f359af23e08447ca6f6346a032acf3b2023-11-22T02:10:49ZengMDPI AGAnimals2076-26152021-06-01117193710.3390/ani11071937Antimicrobial Peptides from Black Soldier Fly (<i>Hermetia illucens</i>) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock FarmingJing Xia0Chaorong Ge1Huaiying Yao2Research Center for Environmental Ecology and Engineering, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan 430073, ChinaResearch Center for Environmental Ecology and Engineering, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan 430073, ChinaResearch Center for Environmental Ecology and Engineering, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan 430073, ChinaFunctional antimicrobial peptides (AMPs) are an important class of effector molecules of innate host immune defense against pathogen invasion. Inability of microorganisms to develop resistance against the majority of AMPs has made them alternatives to antibiotics, contributing to the development of a new generation of antimicrobials. Due to extensive biodiversity, insects are one of the most abundant sources of novel AMPs. Notably, black soldier fly insect (BSF; <i>Hermetia illucens</i> (Diptera: Stratiomyidae)) feeds on decaying substrates and displays a supernormal capacity to survive under adverse conditions in the presence of abundant microorganisms, therefore, BSF is one of the most promising sources for identification of AMPs. However, discovery, functional investigation, and drug development to replace antibiotics with AMPs from <i>Hermetia illucens</i> remain in a preliminary stage. In this review, we provide general information on currently verified AMPs of <i>Hermetia illucens</i>, describe their potential medical value, discuss the mechanism of their synthesis and interactions, and consider the development of bacterial resistance to AMPs in comparison with antibiotics, aiming to provide a candidate for substitution of antibiotics in livestock farming or, to some extent, for blocking the horizontal transfer of resistance genes in the environment, which is beneficial to human and animal welfare.https://www.mdpi.com/2076-2615/11/7/1937antimicrobial peptides<i>Hermetia illucens</i>antibiotic substitutebacterial resistancelivestock farming |
| spellingShingle | Jing Xia Chaorong Ge Huaiying Yao Antimicrobial Peptides from Black Soldier Fly (<i>Hermetia illucens</i>) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming Animals antimicrobial peptides <i>Hermetia illucens</i> antibiotic substitute bacterial resistance livestock farming |
| title | Antimicrobial Peptides from Black Soldier Fly (<i>Hermetia illucens</i>) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming |
| title_full | Antimicrobial Peptides from Black Soldier Fly (<i>Hermetia illucens</i>) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming |
| title_fullStr | Antimicrobial Peptides from Black Soldier Fly (<i>Hermetia illucens</i>) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming |
| title_full_unstemmed | Antimicrobial Peptides from Black Soldier Fly (<i>Hermetia illucens</i>) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming |
| title_short | Antimicrobial Peptides from Black Soldier Fly (<i>Hermetia illucens</i>) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming |
| title_sort | antimicrobial peptides from black soldier fly i hermetia illucens i as potential antimicrobial factors representing an alternative to antibiotics in livestock farming |
| topic | antimicrobial peptides <i>Hermetia illucens</i> antibiotic substitute bacterial resistance livestock farming |
| url | https://www.mdpi.com/2076-2615/11/7/1937 |
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