Supplementation of Mother’s Own Milk with Preterm Donor Human Milk: Impact on Protein Intake and Growth in Very Low Birth Weight Infants—A Randomized Controlled Study
This randomized study investigates whether feeding very low birth weight (VLBW) infants with mother’s own milk (MOM) supplemented with either preterm (PDM) or term donor milk (TDM), when MOM is insufficient, has a positive impact on infants’ protein intake and growth. A hundred and twenty VLBW infan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/3/566 |
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| author | Giannoula Gialeli Anastasia Kapetanaki Ourania Panagopoulou Panagiota Vourna Athanasios Michos Christina Kanaka-Gantenbein George Liosis Tania Siahanidou |
| author_facet | Giannoula Gialeli Anastasia Kapetanaki Ourania Panagopoulou Panagiota Vourna Athanasios Michos Christina Kanaka-Gantenbein George Liosis Tania Siahanidou |
| author_sort | Giannoula Gialeli |
| collection | DOAJ |
| description | This randomized study investigates whether feeding very low birth weight (VLBW) infants with mother’s own milk (MOM) supplemented with either preterm (PDM) or term donor milk (TDM), when MOM is insufficient, has a positive impact on infants’ protein intake and growth. A hundred and twenty VLBW infants were randomized into two groups. Group A (43 infants) received MOM supplemented with PDM, whereas Group B (77 infants) was fed with MOM supplemented with TDM, for the first three weeks of life (donor milk period). Breast milk fortifier was added when milk feeds exceeded 50 mL/Kg/day. After the donor milk period, both groups were fed with formula when MOM was not available or the milk bank was unable to provide TDM. Protein intake was higher in Group A than in Group B at initiation of milk fortification (<i>p</i> = 0.006), as well as during the 3-week donor milk period (<i>p</i> = 0.023) and throughout hospitalization (<i>p</i> = 0.014). Moreover, Group A presented higher Δz-score for body weight (<i>p</i> = 0.019) and head circumference (<i>p</i> = 0.001) from birth to the end of donor milk period, and higher mean body weight at discharge (<i>p</i> = 0.047) compared to Group B. In conclusion, when donor milk is required, PDM positively impacts protein intake and growth in VLBW infants (NCT05675397). |
| first_indexed | 2024-03-11T09:30:29Z |
| format | Article |
| id | doaj.art-6f35abae03864dd3834d54aad8117a65 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T09:30:29Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6f35abae03864dd3834d54aad8117a652023-11-16T17:38:44ZengMDPI AGNutrients2072-66432023-01-0115356610.3390/nu15030566Supplementation of Mother’s Own Milk with Preterm Donor Human Milk: Impact on Protein Intake and Growth in Very Low Birth Weight Infants—A Randomized Controlled StudyGiannoula Gialeli0Anastasia Kapetanaki1Ourania Panagopoulou2Panagiota Vourna3Athanasios Michos4Christina Kanaka-Gantenbein5George Liosis6Tania Siahanidou7Neonatal Intensive Care Unit, “Elena Venizelou” General and Maternal Hospital, 11521 Athens, GreeceNeonatal Intensive Care Unit, “Elena Venizelou” General and Maternal Hospital, 11521 Athens, GreeceNeonatal Intensive Care Unit, “Elena Venizelou” General and Maternal Hospital, 11521 Athens, GreeceNeonatal Intensive Care Unit, “Elena Venizelou” General and Maternal Hospital, 11521 Athens, GreeceFirst Department of Pediatrics, Medical School, National & Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Pediatrics, Medical School, National & Kapodistrian University of Athens, 11527 Athens, GreeceNeonatal Intensive Care Unit, “Elena Venizelou” General and Maternal Hospital, 11521 Athens, GreeceFirst Department of Pediatrics, Medical School, National & Kapodistrian University of Athens, 11527 Athens, GreeceThis randomized study investigates whether feeding very low birth weight (VLBW) infants with mother’s own milk (MOM) supplemented with either preterm (PDM) or term donor milk (TDM), when MOM is insufficient, has a positive impact on infants’ protein intake and growth. A hundred and twenty VLBW infants were randomized into two groups. Group A (43 infants) received MOM supplemented with PDM, whereas Group B (77 infants) was fed with MOM supplemented with TDM, for the first three weeks of life (donor milk period). Breast milk fortifier was added when milk feeds exceeded 50 mL/Kg/day. After the donor milk period, both groups were fed with formula when MOM was not available or the milk bank was unable to provide TDM. Protein intake was higher in Group A than in Group B at initiation of milk fortification (<i>p</i> = 0.006), as well as during the 3-week donor milk period (<i>p</i> = 0.023) and throughout hospitalization (<i>p</i> = 0.014). Moreover, Group A presented higher Δz-score for body weight (<i>p</i> = 0.019) and head circumference (<i>p</i> = 0.001) from birth to the end of donor milk period, and higher mean body weight at discharge (<i>p</i> = 0.047) compared to Group B. In conclusion, when donor milk is required, PDM positively impacts protein intake and growth in VLBW infants (NCT05675397).https://www.mdpi.com/2072-6643/15/3/566preterm donor milkmother’s own milkgrowthVLBW infantsproteinfortification |
| spellingShingle | Giannoula Gialeli Anastasia Kapetanaki Ourania Panagopoulou Panagiota Vourna Athanasios Michos Christina Kanaka-Gantenbein George Liosis Tania Siahanidou Supplementation of Mother’s Own Milk with Preterm Donor Human Milk: Impact on Protein Intake and Growth in Very Low Birth Weight Infants—A Randomized Controlled Study Nutrients preterm donor milk mother’s own milk growth VLBW infants protein fortification |
| title | Supplementation of Mother’s Own Milk with Preterm Donor Human Milk: Impact on Protein Intake and Growth in Very Low Birth Weight Infants—A Randomized Controlled Study |
| title_full | Supplementation of Mother’s Own Milk with Preterm Donor Human Milk: Impact on Protein Intake and Growth in Very Low Birth Weight Infants—A Randomized Controlled Study |
| title_fullStr | Supplementation of Mother’s Own Milk with Preterm Donor Human Milk: Impact on Protein Intake and Growth in Very Low Birth Weight Infants—A Randomized Controlled Study |
| title_full_unstemmed | Supplementation of Mother’s Own Milk with Preterm Donor Human Milk: Impact on Protein Intake and Growth in Very Low Birth Weight Infants—A Randomized Controlled Study |
| title_short | Supplementation of Mother’s Own Milk with Preterm Donor Human Milk: Impact on Protein Intake and Growth in Very Low Birth Weight Infants—A Randomized Controlled Study |
| title_sort | supplementation of mother s own milk with preterm donor human milk impact on protein intake and growth in very low birth weight infants a randomized controlled study |
| topic | preterm donor milk mother’s own milk growth VLBW infants protein fortification |
| url | https://www.mdpi.com/2072-6643/15/3/566 |
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