Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue
Background Colorectal epithelial neoplasm extending into the submucosal gut-associated lymphoid tissue (GALT) can cause difficulties in the differential diagnosis. Regarding GALT-associated epithelial neoplasms, a few studies favor the term “GALT carcinoma” while other studies have mentioned the ter...
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2020-03-01
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| Series: | Journal of Pathology and Translational Medicine |
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| Online Access: | http://jpatholtm.org/upload/pdf/jptm-2019-11-06.pdf |
| _version_ | 1811334259723468800 |
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| author | Yo Han Jeon Ji Hyun Ahn Hee Kyung Chang |
| author_facet | Yo Han Jeon Ji Hyun Ahn Hee Kyung Chang |
| author_sort | Yo Han Jeon |
| collection | DOAJ |
| description | Background Colorectal epithelial neoplasm extending into the submucosal gut-associated lymphoid tissue (GALT) can cause difficulties in the differential diagnosis. Regarding GALT-associated epithelial neoplasms, a few studies favor the term “GALT carcinoma” while other studies have mentioned the term “GALT-associated pseudoinvasion/epithelial misplacement (PEM)”. Methods The clinicopathologic characteristics of 11 cases of colorectal epithelial neoplasm associated with submucosal GALT diagnosed via endoscopic submucosal dissection were studied. Results Eight cases (72.7%) were in males. The median age was 59 years, and age ranged from 53 to 73. All cases had a submucosal tumor component more compatible with GALT-associated PEM. Eight cases (72.7%) were located in the right colon. Ten cases (90.9%) had a non-protruding endoscopic appearance. Nine cases (81.8%) showed continuity between the submucosal and surface adenomatous components. Nine cases showed (81.8%) focal defects or discontinuation of the muscularis mucosae adjacent to the submucosal GALT. No case showed hemosiderin deposits in the submucosa or desmoplastic reaction. No case showed single tumor cells or small clusters of tumor cells in the submucosal GALT. Seven cases (63.6%) showed goblet cells in the submucosa. No cases showed oncocytic columnar cells lining submucosal glands. Conclusions Our experience suggests that pathologists should be aware of the differential diagnosis of GALT-associated submucosal extension by colorectal adenomatous neoplasm. Further studies are needed to validate classification of GALT-associated epithelial neoplasms. |
| first_indexed | 2024-04-13T17:06:04Z |
| format | Article |
| id | doaj.art-6f364f04279e4c77ac9775f9f4debedb |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-04-13T17:06:04Z |
| publishDate | 2020-03-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-6f364f04279e4c77ac9775f9f4debedb2022-12-22T02:38:28ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452020-03-0154213514510.4132/jptm.2019.11.0616889Colorectal epithelial neoplasm associated with gut-associated lymphoid tissueYo Han Jeon0Ji Hyun Ahn1Hee Kyung Chang2 Department of Pathology, Kosin University College of Medicine, Busan, Korea Department of Pathology, Kosin University College of Medicine, Busan, Korea Department of Pathology, Kosin University College of Medicine, Busan, KoreaBackground Colorectal epithelial neoplasm extending into the submucosal gut-associated lymphoid tissue (GALT) can cause difficulties in the differential diagnosis. Regarding GALT-associated epithelial neoplasms, a few studies favor the term “GALT carcinoma” while other studies have mentioned the term “GALT-associated pseudoinvasion/epithelial misplacement (PEM)”. Methods The clinicopathologic characteristics of 11 cases of colorectal epithelial neoplasm associated with submucosal GALT diagnosed via endoscopic submucosal dissection were studied. Results Eight cases (72.7%) were in males. The median age was 59 years, and age ranged from 53 to 73. All cases had a submucosal tumor component more compatible with GALT-associated PEM. Eight cases (72.7%) were located in the right colon. Ten cases (90.9%) had a non-protruding endoscopic appearance. Nine cases (81.8%) showed continuity between the submucosal and surface adenomatous components. Nine cases showed (81.8%) focal defects or discontinuation of the muscularis mucosae adjacent to the submucosal GALT. No case showed hemosiderin deposits in the submucosa or desmoplastic reaction. No case showed single tumor cells or small clusters of tumor cells in the submucosal GALT. Seven cases (63.6%) showed goblet cells in the submucosa. No cases showed oncocytic columnar cells lining submucosal glands. Conclusions Our experience suggests that pathologists should be aware of the differential diagnosis of GALT-associated submucosal extension by colorectal adenomatous neoplasm. Further studies are needed to validate classification of GALT-associated epithelial neoplasms.http://jpatholtm.org/upload/pdf/jptm-2019-11-06.pdfhumanscolorectal neoplasmslymphoid tissueadenomatous polyps |
| spellingShingle | Yo Han Jeon Ji Hyun Ahn Hee Kyung Chang Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue Journal of Pathology and Translational Medicine humans colorectal neoplasms lymphoid tissue adenomatous polyps |
| title | Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue |
| title_full | Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue |
| title_fullStr | Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue |
| title_full_unstemmed | Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue |
| title_short | Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue |
| title_sort | colorectal epithelial neoplasm associated with gut associated lymphoid tissue |
| topic | humans colorectal neoplasms lymphoid tissue adenomatous polyps |
| url | http://jpatholtm.org/upload/pdf/jptm-2019-11-06.pdf |
| work_keys_str_mv | AT yohanjeon colorectalepithelialneoplasmassociatedwithgutassociatedlymphoidtissue AT jihyunahn colorectalepithelialneoplasmassociatedwithgutassociatedlymphoidtissue AT heekyungchang colorectalepithelialneoplasmassociatedwithgutassociatedlymphoidtissue |