Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets
This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/13/5/100 |
| _version_ | 1797567631839985664 |
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| author | Blasco Alejandro Torrado Guillermo Peña M Ángeles |
| author_facet | Blasco Alejandro Torrado Guillermo Peña M Ángeles |
| author_sort | Blasco Alejandro |
| collection | DOAJ |
| description | This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compression method from galenic development to the industrial scale technique, thanks to strategic and support actions between the Spanish Army Force Lab and the Department of Biomedical Sciences (UAH). The results show that loperamide HCl ODT offers a rapid beginning of action and improvement in the bioavailability of poorly absorbed drugs. The manufactured ODTs complied with the pharmacopeia guidelines regarding hardness, weight variation, thickness, friability, drug content, wetting time, percentage of water absorption, disintegration time, and in vitro dissolution profile. Drug compatibility with excipients was checked by DSC, FTIR, and SEM studies. |
| first_indexed | 2024-03-10T19:44:48Z |
| format | Article |
| id | doaj.art-6f380cac8f4047c6915971365ccb2604 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T19:44:48Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-6f380cac8f4047c6915971365ccb26042023-11-20T00:54:01ZengMDPI AGPharmaceuticals1424-82472020-05-0113510010.3390/ph13050100Formulation and Evaluation of Loperamide HCl Oro Dispersible TabletsBlasco Alejandro0Torrado Guillermo1Peña M Ángeles2Centro Militar de Farmacia de la Defensa. Carretera M-609 de Miraflores, Km 34, Colmenar Viejo, 28770 Madrid, SpainUnidad Docente de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Alcalá, Alcalá de Henares, E-28871 Madrid, SpainUnidad Docente de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Alcalá, Alcalá de Henares, E-28871 Madrid, SpainThis work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compression method from galenic development to the industrial scale technique, thanks to strategic and support actions between the Spanish Army Force Lab and the Department of Biomedical Sciences (UAH). The results show that loperamide HCl ODT offers a rapid beginning of action and improvement in the bioavailability of poorly absorbed drugs. The manufactured ODTs complied with the pharmacopeia guidelines regarding hardness, weight variation, thickness, friability, drug content, wetting time, percentage of water absorption, disintegration time, and in vitro dissolution profile. Drug compatibility with excipients was checked by DSC, FTIR, and SEM studies.https://www.mdpi.com/1424-8247/13/5/100loperamide hydrochlorideorodispersible tabletphysicochemical characterization |
| spellingShingle | Blasco Alejandro Torrado Guillermo Peña M Ángeles Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets Pharmaceuticals loperamide hydrochloride orodispersible tablet physicochemical characterization |
| title | Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets |
| title_full | Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets |
| title_fullStr | Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets |
| title_full_unstemmed | Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets |
| title_short | Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets |
| title_sort | formulation and evaluation of loperamide hcl oro dispersible tablets |
| topic | loperamide hydrochloride orodispersible tablet physicochemical characterization |
| url | https://www.mdpi.com/1424-8247/13/5/100 |
| work_keys_str_mv | AT blascoalejandro formulationandevaluationofloperamidehclorodispersibletablets AT torradoguillermo formulationandevaluationofloperamidehclorodispersibletablets AT penamangeles formulationandevaluationofloperamidehclorodispersibletablets |