Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal Destruction
Introduction : Antibiotics treatment for bacillary dysentery due to Shigella dysenteriae infection have shown resistancy. Mangosteen (Garcinia maangostana) peel have a therapy potency for Shigella dysenteriae infection due to its antibacterial and antiinflamation activity. Methods : This research w...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Fakultas Kedokteran Universitas Airlangga
2019-01-01
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| Series: | Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga |
| Online Access: | https://e-journal.unair.ac.id/JUXTA/article/view/10616 |
| _version_ | 1797954171458027520 |
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| author | Achmad Ilham Rizwani Arifa Mustika Lindawati Alimsardjono |
| author_facet | Achmad Ilham Rizwani Arifa Mustika Lindawati Alimsardjono |
| author_sort | Achmad Ilham Rizwani |
| collection | DOAJ |
| description | Introduction : Antibiotics treatment for bacillary dysentery due to Shigella dysenteriae infection have shown resistancy. Mangosteen (Garcinia maangostana) peel have a therapy potency for Shigella dysenteriae infection due to its antibacterial and antiinflamation activity.
Methods : This research was an experimental research, 30 mice was used which divided to 5 groups. The mice was infected with Shigella dysenteriae intraperitoneally, then azithromycin, aquadest, and 3 different doses of mangosteen (Garcinia mangostana) peel was given for each group for 5 days, which then the mice’s colon was collected and made into histopathology slide and its mucosal destruction was observed in 3 fields of view in each slide, 1 – 4 score was given acording to its mucosal destruction. Kruskal-Wallis test is used to analyze the data and then Mann Whitney test also used for further analysis.
Result : there was a healing effect obeserved when mangosteen (Garcinia mangostana) peel extract was given to the mice’s colon mucosal, 100 mg/Kg body mass dose of mangosteen (Garcinia mangostana) peel extract already given a positive effect on mice’s mucosal colon histopathological appearance, no difference observed between 3 dose given.
Conclusion : Mangosteen (Garcinia mangostana) peel extract consumption gave healing appearance to destruction of colon mucosal wall of mice with Shigella dysenteriae infection at 100 mg/Kg body mass. |
| first_indexed | 2024-04-10T23:13:24Z |
| format | Article |
| id | doaj.art-6f39b06dae6743f495a81fdaa7da3890 |
| institution | Directory Open Access Journal |
| issn | 1907-3623 2684-9453 |
| language | English |
| last_indexed | 2024-04-10T23:13:24Z |
| publishDate | 2019-01-01 |
| publisher | Fakultas Kedokteran Universitas Airlangga |
| record_format | Article |
| series | Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga |
| spelling | doaj.art-6f39b06dae6743f495a81fdaa7da38902023-01-13T03:44:02ZengFakultas Kedokteran Universitas AirlanggaJuxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga1907-36232684-94532019-01-0110151010.20473/juxta.V10I12019.5-108423Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal DestructionAchmad Ilham Rizwani0Arifa Mustika1Lindawati Alimsardjono2Universitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaIntroduction : Antibiotics treatment for bacillary dysentery due to Shigella dysenteriae infection have shown resistancy. Mangosteen (Garcinia maangostana) peel have a therapy potency for Shigella dysenteriae infection due to its antibacterial and antiinflamation activity. Methods : This research was an experimental research, 30 mice was used which divided to 5 groups. The mice was infected with Shigella dysenteriae intraperitoneally, then azithromycin, aquadest, and 3 different doses of mangosteen (Garcinia mangostana) peel was given for each group for 5 days, which then the mice’s colon was collected and made into histopathology slide and its mucosal destruction was observed in 3 fields of view in each slide, 1 – 4 score was given acording to its mucosal destruction. Kruskal-Wallis test is used to analyze the data and then Mann Whitney test also used for further analysis. Result : there was a healing effect obeserved when mangosteen (Garcinia mangostana) peel extract was given to the mice’s colon mucosal, 100 mg/Kg body mass dose of mangosteen (Garcinia mangostana) peel extract already given a positive effect on mice’s mucosal colon histopathological appearance, no difference observed between 3 dose given. Conclusion : Mangosteen (Garcinia mangostana) peel extract consumption gave healing appearance to destruction of colon mucosal wall of mice with Shigella dysenteriae infection at 100 mg/Kg body mass.https://e-journal.unair.ac.id/JUXTA/article/view/10616 |
| spellingShingle | Achmad Ilham Rizwani Arifa Mustika Lindawati Alimsardjono Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal Destruction Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga |
| title | Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal Destruction |
| title_full | Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal Destruction |
| title_fullStr | Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal Destruction |
| title_full_unstemmed | Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal Destruction |
| title_short | Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal Destruction |
| title_sort | therapeutic potency of mangosteen garcinia mangostana peel extract for shigella dysenteriae infected mice s colon mucosal destruction |
| url | https://e-journal.unair.ac.id/JUXTA/article/view/10616 |
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