Differential Foreign Body Reactions between Branched and Linear Glucomannan Scaffolds
The extent and patterns of foreign body reaction (FBR) influence the function and feasibility of biomaterials. Polysaccharides, as an important biomaterial category, have received increasing attention in diverse biomaterials design and biomedical applications due to their excellent polymeric and bio...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/293 |
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| author | Yuwei Li Yu Liu Senio Campos de Souza Tzuwei Chao Lei Dong Guoxing Sun Chunming Wang Yiming Niu |
| author_facet | Yuwei Li Yu Liu Senio Campos de Souza Tzuwei Chao Lei Dong Guoxing Sun Chunming Wang Yiming Niu |
| author_sort | Yuwei Li |
| collection | DOAJ |
| description | The extent and patterns of foreign body reaction (FBR) influence the function and feasibility of biomaterials. Polysaccharides, as an important biomaterial category, have received increasing attention in diverse biomaterials design and biomedical applications due to their excellent polymeric and biocompatible characteristics. Their biological effects are usually associated with their monosaccharide composition or functional groups, yet the contribution of their glycan structure is still unknown. Herein, two glucomannans, similar in composition and molecular weight with differences in glycan structure, linear-chain (Konjac glucomannan, KGM), and branched-chain (<i>Bletilla striata</i> polysaccharide, BSP), were adopted to explore the host–biomaterials interaction. After acetyl modification, these polysaccharides were fabricated into electrospun scaffolds to reduce the impacts derived from the physical properties and surface morphology. According to a systematic study of their biological effects on immune cells and host response in a subcutaneous implantation model in vivo, it was revealed that acetyl KGM (acKGM) scaffolds caused a stronger FBR than acetyl BSP materials. Additionally, acKGM could stimulate macrophages to release pro-inflammatory cytokines, suggesting the influence of sugar chain arrangement on FBR and providing clues for the fine regulation of immune response and novel biomaterials design. |
| first_indexed | 2024-03-09T16:14:55Z |
| format | Article |
| id | doaj.art-6f3a0a1c78a74812b55e272e6cf1b910 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:14:55Z |
| publishDate | 2022-12-01 |
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| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-6f3a0a1c78a74812b55e272e6cf1b9102023-11-24T15:50:57ZengMDPI AGJournal of Functional Biomaterials2079-49832022-12-0113429310.3390/jfb13040293Differential Foreign Body Reactions between Branched and Linear Glucomannan ScaffoldsYuwei Li0Yu Liu1Senio Campos de Souza2Tzuwei Chao3Lei Dong4Guoxing Sun5Chunming Wang6Yiming Niu7State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, Department of Pharmaceutical Sciences, Faculty of Health Science, University of Macau, Taipa, Macau SAR 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, Department of Pharmaceutical Sciences, Faculty of Health Science, University of Macau, Taipa, Macau SAR 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, Department of Pharmaceutical Sciences, Faculty of Health Science, University of Macau, Taipa, Macau SAR 999078, ChinaFaculty of Health Sciences, University of Macau, Macau SAR 999078, ChinaState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, ChinaJoint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau SAR 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, Department of Pharmaceutical Sciences, Faculty of Health Science, University of Macau, Taipa, Macau SAR 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, Department of Pharmaceutical Sciences, Faculty of Health Science, University of Macau, Taipa, Macau SAR 999078, ChinaThe extent and patterns of foreign body reaction (FBR) influence the function and feasibility of biomaterials. Polysaccharides, as an important biomaterial category, have received increasing attention in diverse biomaterials design and biomedical applications due to their excellent polymeric and biocompatible characteristics. Their biological effects are usually associated with their monosaccharide composition or functional groups, yet the contribution of their glycan structure is still unknown. Herein, two glucomannans, similar in composition and molecular weight with differences in glycan structure, linear-chain (Konjac glucomannan, KGM), and branched-chain (<i>Bletilla striata</i> polysaccharide, BSP), were adopted to explore the host–biomaterials interaction. After acetyl modification, these polysaccharides were fabricated into electrospun scaffolds to reduce the impacts derived from the physical properties and surface morphology. According to a systematic study of their biological effects on immune cells and host response in a subcutaneous implantation model in vivo, it was revealed that acetyl KGM (acKGM) scaffolds caused a stronger FBR than acetyl BSP materials. Additionally, acKGM could stimulate macrophages to release pro-inflammatory cytokines, suggesting the influence of sugar chain arrangement on FBR and providing clues for the fine regulation of immune response and novel biomaterials design.https://www.mdpi.com/2079-4983/13/4/293glucomannanpolysaccharide structureelectrospun scaffoldsimmune responseforeign body reaction |
| spellingShingle | Yuwei Li Yu Liu Senio Campos de Souza Tzuwei Chao Lei Dong Guoxing Sun Chunming Wang Yiming Niu Differential Foreign Body Reactions between Branched and Linear Glucomannan Scaffolds Journal of Functional Biomaterials glucomannan polysaccharide structure electrospun scaffolds immune response foreign body reaction |
| title | Differential Foreign Body Reactions between Branched and Linear Glucomannan Scaffolds |
| title_full | Differential Foreign Body Reactions between Branched and Linear Glucomannan Scaffolds |
| title_fullStr | Differential Foreign Body Reactions between Branched and Linear Glucomannan Scaffolds |
| title_full_unstemmed | Differential Foreign Body Reactions between Branched and Linear Glucomannan Scaffolds |
| title_short | Differential Foreign Body Reactions between Branched and Linear Glucomannan Scaffolds |
| title_sort | differential foreign body reactions between branched and linear glucomannan scaffolds |
| topic | glucomannan polysaccharide structure electrospun scaffolds immune response foreign body reaction |
| url | https://www.mdpi.com/2079-4983/13/4/293 |
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