Recent advances of photodynamic therapy for biliary tract cancer
The prognosis of bile duct cancer (BDC) is limited due to tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Palliation with biliary endoprostheses yields median survival times between 4 and 6 months for advanced BDC. Photodynamic thera...
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| Format: | Article |
| Language: | English |
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Society of Gastrointestinal Intervention
2021-07-01
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| Series: | International Journal of Gastrointestinal Intervention |
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| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.18528/ijgii210032 |
| _version_ | 1818613724045377536 |
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| author | Young Koog Cheon |
| author_facet | Young Koog Cheon |
| author_sort | Young Koog Cheon |
| collection | DOAJ |
| description | The prognosis of bile duct cancer (BDC) is limited due to tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Palliation with biliary endoprostheses yields median survival times between 4 and 6 months for advanced BDC. Photodynamic therapy (PDT) is a local photochemical tumor treatment that consists of a photosensitizing agent combined with laser irradiation of a distinct wavelength. Tumor ablation with PDT combined with biliary stenting reduces cholestasis and significantly improves the median survival time. However, the treatment is not widely available, and the photosensitizer used for PDT causes prolonged photosensitivity. Optimal control of tumor spread along the bile ducts and control of cholestasis and cholangitis will prolong survival in 33% to 66% of patients and render them suitable for other antitumor therapies. |
| first_indexed | 2024-12-16T16:06:40Z |
| format | Article |
| id | doaj.art-6f3bba2da910441295520e35848226b4 |
| institution | Directory Open Access Journal |
| issn | 2636-0004 |
| language | English |
| last_indexed | 2024-12-16T16:06:40Z |
| publishDate | 2021-07-01 |
| publisher | Society of Gastrointestinal Intervention |
| record_format | Article |
| series | International Journal of Gastrointestinal Intervention |
| spelling | doaj.art-6f3bba2da910441295520e35848226b42022-12-21T22:25:21ZengSociety of Gastrointestinal InterventionInternational Journal of Gastrointestinal Intervention2636-00042021-07-011039610010.18528/ijgii210032ijgii210032Recent advances of photodynamic therapy for biliary tract cancerYoung Koog Cheon0Department of Internal Medicine, Digestive Disease Center, Konkuk University School of Medicine, Seoul, KoreaThe prognosis of bile duct cancer (BDC) is limited due to tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Palliation with biliary endoprostheses yields median survival times between 4 and 6 months for advanced BDC. Photodynamic therapy (PDT) is a local photochemical tumor treatment that consists of a photosensitizing agent combined with laser irradiation of a distinct wavelength. Tumor ablation with PDT combined with biliary stenting reduces cholestasis and significantly improves the median survival time. However, the treatment is not widely available, and the photosensitizer used for PDT causes prolonged photosensitivity. Optimal control of tumor spread along the bile ducts and control of cholestasis and cholangitis will prolong survival in 33% to 66% of patients and render them suitable for other antitumor therapies.http://journaleditor.inforang.com/journal/view.html?doi=10.18528/ijgii210032bile duct cancer; photodynamic therapy; photosensitizer |
| spellingShingle | Young Koog Cheon Recent advances of photodynamic therapy for biliary tract cancer International Journal of Gastrointestinal Intervention bile duct cancer; photodynamic therapy; photosensitizer |
| title | Recent advances of photodynamic therapy for biliary tract cancer |
| title_full | Recent advances of photodynamic therapy for biliary tract cancer |
| title_fullStr | Recent advances of photodynamic therapy for biliary tract cancer |
| title_full_unstemmed | Recent advances of photodynamic therapy for biliary tract cancer |
| title_short | Recent advances of photodynamic therapy for biliary tract cancer |
| title_sort | recent advances of photodynamic therapy for biliary tract cancer |
| topic | bile duct cancer; photodynamic therapy; photosensitizer |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.18528/ijgii210032 |
| work_keys_str_mv | AT youngkoogcheon recentadvancesofphotodynamictherapyforbiliarytractcancer |