Long-term persistence of anti-HBs after hepatitis B vaccination among adults: 8-year results
The long-term persistence of hepatitis B surface antibody (anti-HBs) after hepatitis B vaccination among adults was not known clearly. This study aimed to assess the immunogenicity and persistence of antibodies 8 years after hepatitis B immunization with different vaccination schedules among adults...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-03-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2019.1666612 |
| _version_ | 1827809720469028864 |
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| author | Wen Ren Jingjing Ren Zikang Wu Lingzhi Shen Huan Shan Xuewei Dai Jing Li Ying Liu Yan Qiu Jun Yao Lanjuan Li |
| author_facet | Wen Ren Jingjing Ren Zikang Wu Lingzhi Shen Huan Shan Xuewei Dai Jing Li Ying Liu Yan Qiu Jun Yao Lanjuan Li |
| author_sort | Wen Ren |
| collection | DOAJ |
| description | The long-term persistence of hepatitis B surface antibody (anti-HBs) after hepatitis B vaccination among adults was not known clearly. This study aimed to assess the immunogenicity and persistence of antibodies 8 years after hepatitis B immunization with different vaccination schedules among adults who tested negative for hepatitis B surface antigen (HBsAg), anti-HBs, and hepatitis B core antibody (anti-HBc). A total of 771 participants who received the full vaccination course (three doses) and also had a blood sample taken 1 month after the first vaccination were recruited. Of these, 529 were excluded due to the missing data of anti-HBs 8 years after the first vaccination. Vaccinations were carried out at 0–1–3, 0–1–6 and 0–1–12 month vaccination schedules, and 104, 45, and 93 participants were included, respectively. The positive seroprotection rate was 85.9% 1 month after the third vaccination, and 58.3% 8 years later (χ2 = 54.52, P < .001), while the geometric mean titer (GMT) of anti-HBs was 158.49 mIU/mL [95% confidence interval (CI): 131.83–190.55)] and 15.14 mIU/mL (95% CI: 10.96–20.42) after 1 month and 8 years, respectively. Compared with the standard 0–1–6 month vaccination schedule, the positive seroprotection rate and the GMT of the 0–1–3 month vaccination schedule had no difference. The long-term immune effect of the 0–1–3 month vaccination schedule was better than that of the 0–1–12 month vaccination schedule. No correlation was found between the GMT of anti-HBs 1 month and 8 years later. |
| first_indexed | 2024-03-11T22:43:44Z |
| format | Article |
| id | doaj.art-6f3cb6d2fd5a45f29378529884bebb38 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:43:44Z |
| publishDate | 2020-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-6f3cb6d2fd5a45f29378529884bebb382023-09-22T08:45:33ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2020-03-0116368769210.1080/21645515.2019.16666121666612Long-term persistence of anti-HBs after hepatitis B vaccination among adults: 8-year resultsWen Ren0Jingjing Ren1Zikang Wu2Lingzhi Shen3Huan Shan4Xuewei Dai5Jing Li6Ying Liu7Yan Qiu8Jun Yao9Lanjuan Li10Zhejiang UniversityZhejiang UniversityZhejiang Provincial Center for Disease Control and preventionZhejiang Provincial Center for Disease Control and preventionZhejiang HospitalJingdezhen Center for Disease Control and preventionZhejiang HospitalZhejiang UniversityZhejiang UniversityZhejiang Provincial Center for Disease Control and preventionZhejiang UniversityThe long-term persistence of hepatitis B surface antibody (anti-HBs) after hepatitis B vaccination among adults was not known clearly. This study aimed to assess the immunogenicity and persistence of antibodies 8 years after hepatitis B immunization with different vaccination schedules among adults who tested negative for hepatitis B surface antigen (HBsAg), anti-HBs, and hepatitis B core antibody (anti-HBc). A total of 771 participants who received the full vaccination course (three doses) and also had a blood sample taken 1 month after the first vaccination were recruited. Of these, 529 were excluded due to the missing data of anti-HBs 8 years after the first vaccination. Vaccinations were carried out at 0–1–3, 0–1–6 and 0–1–12 month vaccination schedules, and 104, 45, and 93 participants were included, respectively. The positive seroprotection rate was 85.9% 1 month after the third vaccination, and 58.3% 8 years later (χ2 = 54.52, P < .001), while the geometric mean titer (GMT) of anti-HBs was 158.49 mIU/mL [95% confidence interval (CI): 131.83–190.55)] and 15.14 mIU/mL (95% CI: 10.96–20.42) after 1 month and 8 years, respectively. Compared with the standard 0–1–6 month vaccination schedule, the positive seroprotection rate and the GMT of the 0–1–3 month vaccination schedule had no difference. The long-term immune effect of the 0–1–3 month vaccination schedule was better than that of the 0–1–12 month vaccination schedule. No correlation was found between the GMT of anti-HBs 1 month and 8 years later.http://dx.doi.org/10.1080/21645515.2019.1666612hepatitis b virusvaccineimmune effectadultimmunogenicity |
| spellingShingle | Wen Ren Jingjing Ren Zikang Wu Lingzhi Shen Huan Shan Xuewei Dai Jing Li Ying Liu Yan Qiu Jun Yao Lanjuan Li Long-term persistence of anti-HBs after hepatitis B vaccination among adults: 8-year results Human Vaccines & Immunotherapeutics hepatitis b virus vaccine immune effect adult immunogenicity |
| title | Long-term persistence of anti-HBs after hepatitis B vaccination among adults: 8-year results |
| title_full | Long-term persistence of anti-HBs after hepatitis B vaccination among adults: 8-year results |
| title_fullStr | Long-term persistence of anti-HBs after hepatitis B vaccination among adults: 8-year results |
| title_full_unstemmed | Long-term persistence of anti-HBs after hepatitis B vaccination among adults: 8-year results |
| title_short | Long-term persistence of anti-HBs after hepatitis B vaccination among adults: 8-year results |
| title_sort | long term persistence of anti hbs after hepatitis b vaccination among adults 8 year results |
| topic | hepatitis b virus vaccine immune effect adult immunogenicity |
| url | http://dx.doi.org/10.1080/21645515.2019.1666612 |
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