Clinicopathological response assessment to neoadjuvant chemotherapy in locally advanced breast cancer- A rural population-based case series
Introduction: Breast cancer is the commonest malignancy among women worldwide. Despite a multidisciplinary approach, locally advanced breast cancer remains a clinical challenge as most of the patients have a high rate of locoregional spread and develop distant metastases. Neoadjuvant chemotherapy n...
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| Format: | Article |
| Language: | English |
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Zabansaraye Parsian Novin Mehr Institute
2023-06-01
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| Series: | Journal of Current Oncology and Medical Sciences |
| Subjects: | |
| Online Access: | http://submission.journalofcoms.com/index.php/JCOMS/article/view/128 |
| _version_ | 1797784829910056960 |
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| author | Kailash Kumar Thakuria Sushmita Ray Rahul Sarma |
| author_facet | Kailash Kumar Thakuria Sushmita Ray Rahul Sarma |
| author_sort | Kailash Kumar Thakuria |
| collection | DOAJ |
| description | Introduction: Breast cancer is the commonest malignancy among women worldwide. Despite a multidisciplinary approach, locally advanced breast cancer remains a clinical challenge as most of the patients have a high rate of locoregional spread and develop distant metastases. Neoadjuvant chemotherapy not only paves the way for a more conservative surgical option but also decreases the incidence of positive nodes. To assess the effectiveness of neo-adjuvant chemotherapy and its impact on clinical and pathological response in locally advanced breast cancer. To compare patient characteristics, histological type, and hormonal receptor status with response to neo-adjuvant chemotherapy.
Materials and Methods: This is a prospective observational study over a one-year period on 30 locally advanced breast cancer patients from rural backgrounds who received neoadjuvant chemotherapy. All patients received a standard neoadjuvant treatment regimen and were evaluated clinically, radiologically, and pathologically pre- and post-chemotherapy. The clinical response was assessed by RECIST criteria, the pathological response was graded according to Chevalier classification, and the overall impact was assessed by AJCC response criteria.
Results: Most of the patients (46.7%) were in the age group of 35-48 years. The premenopausal and postmenopausal groups were 63% and 37%, respectively. In the present study, tumours expressing estrogen, progesterone, and HER 2 were 73%, 66%, and 27%, respectively. Patients showing clinically complete responses post-neoadjuvant chemotherapy were 4, partial responses were 21, stable disease was 3, and progressive disease was 2. A pathological partial response was achieved in 93% of patients.
Conclusion: Neoadjuvant chemotherapy in locally advanced breast cancer not only downstages the disease but increases the scope of operability and thus makes it possible to resect the disease with a tumour-free margin in most cases. |
| first_indexed | 2024-03-13T00:45:30Z |
| format | Article |
| id | doaj.art-6f40589f9f1d4f88807414a63684aafe |
| institution | Directory Open Access Journal |
| issn | 2783-3127 |
| language | English |
| last_indexed | 2024-03-13T00:45:30Z |
| publishDate | 2023-06-01 |
| publisher | Zabansaraye Parsian Novin Mehr Institute |
| record_format | Article |
| series | Journal of Current Oncology and Medical Sciences |
| spelling | doaj.art-6f40589f9f1d4f88807414a63684aafe2023-07-09T08:33:01ZengZabansaraye Parsian Novin Mehr InstituteJournal of Current Oncology and Medical Sciences2783-31272023-06-0132445451Clinicopathological response assessment to neoadjuvant chemotherapy in locally advanced breast cancer- A rural population-based case seriesKailash Kumar Thakuria0Sushmita Ray1Rahul Sarma2Kokrajhar Medical College and Hospital, Assam, IndiaFakhruddin Ali Ahmed Medical College and Hospital, Barpeta, Assam, IndiaFakhruddin Ali Ahmed Medical College and Hospital, Barpeta, Assam, IndiaIntroduction: Breast cancer is the commonest malignancy among women worldwide. Despite a multidisciplinary approach, locally advanced breast cancer remains a clinical challenge as most of the patients have a high rate of locoregional spread and develop distant metastases. Neoadjuvant chemotherapy not only paves the way for a more conservative surgical option but also decreases the incidence of positive nodes. To assess the effectiveness of neo-adjuvant chemotherapy and its impact on clinical and pathological response in locally advanced breast cancer. To compare patient characteristics, histological type, and hormonal receptor status with response to neo-adjuvant chemotherapy. Materials and Methods: This is a prospective observational study over a one-year period on 30 locally advanced breast cancer patients from rural backgrounds who received neoadjuvant chemotherapy. All patients received a standard neoadjuvant treatment regimen and were evaluated clinically, radiologically, and pathologically pre- and post-chemotherapy. The clinical response was assessed by RECIST criteria, the pathological response was graded according to Chevalier classification, and the overall impact was assessed by AJCC response criteria. Results: Most of the patients (46.7%) were in the age group of 35-48 years. The premenopausal and postmenopausal groups were 63% and 37%, respectively. In the present study, tumours expressing estrogen, progesterone, and HER 2 were 73%, 66%, and 27%, respectively. Patients showing clinically complete responses post-neoadjuvant chemotherapy were 4, partial responses were 21, stable disease was 3, and progressive disease was 2. A pathological partial response was achieved in 93% of patients. Conclusion: Neoadjuvant chemotherapy in locally advanced breast cancer not only downstages the disease but increases the scope of operability and thus makes it possible to resect the disease with a tumour-free margin in most cases.http://submission.journalofcoms.com/index.php/JCOMS/article/view/128locally advanced breast cancer (labc)neoadjuvant chemotherapy (nact) |
| spellingShingle | Kailash Kumar Thakuria Sushmita Ray Rahul Sarma Clinicopathological response assessment to neoadjuvant chemotherapy in locally advanced breast cancer- A rural population-based case series Journal of Current Oncology and Medical Sciences locally advanced breast cancer (labc) neoadjuvant chemotherapy (nact) |
| title | Clinicopathological response assessment to neoadjuvant chemotherapy in locally advanced breast cancer- A rural population-based case series |
| title_full | Clinicopathological response assessment to neoadjuvant chemotherapy in locally advanced breast cancer- A rural population-based case series |
| title_fullStr | Clinicopathological response assessment to neoadjuvant chemotherapy in locally advanced breast cancer- A rural population-based case series |
| title_full_unstemmed | Clinicopathological response assessment to neoadjuvant chemotherapy in locally advanced breast cancer- A rural population-based case series |
| title_short | Clinicopathological response assessment to neoadjuvant chemotherapy in locally advanced breast cancer- A rural population-based case series |
| title_sort | clinicopathological response assessment to neoadjuvant chemotherapy in locally advanced breast cancer a rural population based case series |
| topic | locally advanced breast cancer (labc) neoadjuvant chemotherapy (nact) |
| url | http://submission.journalofcoms.com/index.php/JCOMS/article/view/128 |
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