Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal study
Abstract Objective The objective of the study was to evaluate the relation between occlusal loading and peri-implant crevicular fluid cytokine expression in patients with implant-supported complete fixed prostheses in both arches. Material and methods A prospective longitudinal clinical study was pe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-10-01
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| Series: | International Journal of Implant Dentistry |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40729-020-00262-2 |
| _version_ | 1811323753731194880 |
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| author | Jose Viña-Almunia Hilario Pellicer-Chover Berta García-Mira Javier Romero-Millán David Peñarrocha-Oltra Miguel Peñarrocha-Diago |
| author_facet | Jose Viña-Almunia Hilario Pellicer-Chover Berta García-Mira Javier Romero-Millán David Peñarrocha-Oltra Miguel Peñarrocha-Diago |
| author_sort | Jose Viña-Almunia |
| collection | DOAJ |
| description | Abstract Objective The objective of the study was to evaluate the relation between occlusal loading and peri-implant crevicular fluid cytokine expression in patients with implant-supported complete fixed prostheses in both arches. Material and methods A prospective longitudinal clinical study was performed at a university clinic. Fifteen patients were selected and 11 were included. All patients had bimaxillary implant-supported complete fixed ceramo-metallic prostheses loaded at least 12 months before the beginning of the study. Allocation was established for each patient using a computerized occlusal analysis system. The test implant was the maxillary implant closest to the point of highest occlusal loading. The maxillary implant with least loading was the control implant. Occlusal adjustment was performed using a round diamond burr. This occlusal distribution was verified with the occlusal analysis system. Expression of cytokines from peri-implant crevicular fluid (TNF-α, IL-10, IL-6, IL-1β, IL-8) were recorded and analyzed in both test and control implants before (baseline: T0) and 2 (T1) and 12 months (T2) after occlusal adjustment. The Brunner-Langer non-parametric test was performed. Results At T0, the expression of IL-10 was significantly higher in the test group implants (p = 0.018). Between T0 and T1, the expression of all the cytokines decreased in the implants of both groups with statistically significant differences, except for TNF (p = 0.271). When comparing both groups at T1, there was no statistically significant difference in any of the analyzed cytokines. At T2, TNF-α suffered when compared with baseline, a statistical decrease in both study and control implants (p < 0,001). At T2, there were no statistically significant differences between groups in any of the cytokines analyzed. Conclusions Implants with higher occlusal load presented higher expression of IL-10 in peri-implant crevicular fluid. Occlusal adjustment produced a decrease in the expression of all the analyzed cytokines, both in test and control implants. |
| first_indexed | 2024-04-13T14:01:25Z |
| format | Article |
| id | doaj.art-6f411de57157412bbb13826f6e0381ea |
| institution | Directory Open Access Journal |
| issn | 2198-4034 |
| language | English |
| last_indexed | 2024-04-13T14:01:25Z |
| publishDate | 2020-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Implant Dentistry |
| spelling | doaj.art-6f411de57157412bbb13826f6e0381ea2022-12-22T02:44:02ZengSpringerOpenInternational Journal of Implant Dentistry2198-40342020-10-01611710.1186/s40729-020-00262-2Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal studyJose Viña-Almunia0Hilario Pellicer-Chover1Berta García-Mira2Javier Romero-Millán3David Peñarrocha-Oltra4Miguel Peñarrocha-Diago5Oral Surgery and Implantology Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of ValenciaOral Surgery and Implantology Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of ValenciaOral Surgery and Implantology Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of ValenciaOral Surgery and Implantology Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of ValenciaOral Surgery and Implantology Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of ValenciaOral Surgery and Implantology Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of ValenciaAbstract Objective The objective of the study was to evaluate the relation between occlusal loading and peri-implant crevicular fluid cytokine expression in patients with implant-supported complete fixed prostheses in both arches. Material and methods A prospective longitudinal clinical study was performed at a university clinic. Fifteen patients were selected and 11 were included. All patients had bimaxillary implant-supported complete fixed ceramo-metallic prostheses loaded at least 12 months before the beginning of the study. Allocation was established for each patient using a computerized occlusal analysis system. The test implant was the maxillary implant closest to the point of highest occlusal loading. The maxillary implant with least loading was the control implant. Occlusal adjustment was performed using a round diamond burr. This occlusal distribution was verified with the occlusal analysis system. Expression of cytokines from peri-implant crevicular fluid (TNF-α, IL-10, IL-6, IL-1β, IL-8) were recorded and analyzed in both test and control implants before (baseline: T0) and 2 (T1) and 12 months (T2) after occlusal adjustment. The Brunner-Langer non-parametric test was performed. Results At T0, the expression of IL-10 was significantly higher in the test group implants (p = 0.018). Between T0 and T1, the expression of all the cytokines decreased in the implants of both groups with statistically significant differences, except for TNF (p = 0.271). When comparing both groups at T1, there was no statistically significant difference in any of the analyzed cytokines. At T2, TNF-α suffered when compared with baseline, a statistical decrease in both study and control implants (p < 0,001). At T2, there were no statistically significant differences between groups in any of the cytokines analyzed. Conclusions Implants with higher occlusal load presented higher expression of IL-10 in peri-implant crevicular fluid. Occlusal adjustment produced a decrease in the expression of all the analyzed cytokines, both in test and control implants.http://link.springer.com/article/10.1186/s40729-020-00262-2Occlusal loadingCrevicular fluidPeri-implant clinical parametersCytokines |
| spellingShingle | Jose Viña-Almunia Hilario Pellicer-Chover Berta García-Mira Javier Romero-Millán David Peñarrocha-Oltra Miguel Peñarrocha-Diago Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal study International Journal of Implant Dentistry Occlusal loading Crevicular fluid Peri-implant clinical parameters Cytokines |
| title | Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal study |
| title_full | Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal study |
| title_fullStr | Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal study |
| title_full_unstemmed | Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal study |
| title_short | Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal study |
| title_sort | influence of occlusal loading on peri implant inflammatory cytokines in crevicular fluid a prospective longitudinal study |
| topic | Occlusal loading Crevicular fluid Peri-implant clinical parameters Cytokines |
| url | http://link.springer.com/article/10.1186/s40729-020-00262-2 |
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