The effect of maternal pregestational diabetes on fetal autonomic nervous system
Abstract Heart rate variability assessment of neonates of pregestational diabetic mothers have shown alterations in the autonomic nervous system (ANS). The objective was to study the effect of maternal pregestational diabetes on ANS at the fetal stage by combining cardiac and movement parameters usi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15680 |
| _version_ | 1797397142963224576 |
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| author | Luis Mercado Diana Escalona‐Vargas Sarah Blossom Eric R. Siegel Julie R. Whittington Hubert Preissl Kaitlyn Walden Hari Eswaran |
| author_facet | Luis Mercado Diana Escalona‐Vargas Sarah Blossom Eric R. Siegel Julie R. Whittington Hubert Preissl Kaitlyn Walden Hari Eswaran |
| author_sort | Luis Mercado |
| collection | DOAJ |
| description | Abstract Heart rate variability assessment of neonates of pregestational diabetic mothers have shown alterations in the autonomic nervous system (ANS). The objective was to study the effect of maternal pregestational diabetes on ANS at the fetal stage by combining cardiac and movement parameters using a non‐invasive fetal magnetocardiography (fMCG) technique. This is an observational study with 40 participants where fetuses from a group of 9 Type 1, 19 Type 2 diabetic, and 12 non‐diabetic pregnant women were included. Time and frequency domain fetal heart rate variability (fHRV) and coupling of movement and heart rate acceleration parameters related to fetal ANS were analyzed. Group differences were investigated using analysis of covariance to adjust for gestational age (GA). When compared to non‐diabetics, the Type 1 diabetics had a 65% increase in average ratio of very low‐frequency (VLF) to low‐frequency (LF) bands and 63% average decrease in coupling index after adjusting for GA. Comparing Type 2 diabetics to non‐diabetics, there was an average decrease in the VLF (50%) and LF bands (63%). Diabetics with poor glycemic control had a higher average VLF/LF (49%) than diabetics with good glycemic control. No significant changes at p < 0.05 were observed in high‐frequency (HF) frequency domain parameters or their ratios, or in the time domain. Fetuses of pregestational diabetic mothers exhibited some differences in fHRV frequency domain and heart rate‐movement coupling when compared to non‐diabetics but the effect of fHRV related to fetal ANS and sympathovagal balance were not as conclusive as observed in the neonates of pregestational diabetic mothers. |
| first_indexed | 2024-03-09T01:05:41Z |
| format | Article |
| id | doaj.art-6f429be2acda49f18dea501f60fb0c89 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-09T01:05:41Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-6f429be2acda49f18dea501f60fb0c892023-12-11T10:01:16ZengWileyPhysiological Reports2051-817X2023-05-01119n/an/a10.14814/phy2.15680The effect of maternal pregestational diabetes on fetal autonomic nervous systemLuis Mercado0Diana Escalona‐Vargas1Sarah Blossom2Eric R. Siegel3Julie R. Whittington4Hubert Preissl5Kaitlyn Walden6Hari Eswaran7Division of Maternal‐Fetal Medicine, Department of Obstetrics and Gynecology University of Arkansas for Medical Sciences Little Rock Arkansas USADivision of Maternal‐Fetal Medicine, Department of Obstetrics and Gynecology University of Arkansas for Medical Sciences Little Rock Arkansas USADepartment of Pediatrics University of Arkansas for Medical Sciences Arkansas Children's Research Institute Little Rock Arkansas USADepartment of Biostatistics University of Arkansas for Medical Sciences Little Rock Arkansas USADivision of Maternal‐Fetal Medicine, Department of Obstetrics and Gynecology University of Arkansas for Medical Sciences Little Rock Arkansas USAInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen German Center for Diabetes Research (DZD) Tübingen GermanyDivision of Maternal‐Fetal Medicine, Department of Obstetrics and Gynecology University of Arkansas for Medical Sciences Little Rock Arkansas USADivision of Maternal‐Fetal Medicine, Department of Obstetrics and Gynecology University of Arkansas for Medical Sciences Little Rock Arkansas USAAbstract Heart rate variability assessment of neonates of pregestational diabetic mothers have shown alterations in the autonomic nervous system (ANS). The objective was to study the effect of maternal pregestational diabetes on ANS at the fetal stage by combining cardiac and movement parameters using a non‐invasive fetal magnetocardiography (fMCG) technique. This is an observational study with 40 participants where fetuses from a group of 9 Type 1, 19 Type 2 diabetic, and 12 non‐diabetic pregnant women were included. Time and frequency domain fetal heart rate variability (fHRV) and coupling of movement and heart rate acceleration parameters related to fetal ANS were analyzed. Group differences were investigated using analysis of covariance to adjust for gestational age (GA). When compared to non‐diabetics, the Type 1 diabetics had a 65% increase in average ratio of very low‐frequency (VLF) to low‐frequency (LF) bands and 63% average decrease in coupling index after adjusting for GA. Comparing Type 2 diabetics to non‐diabetics, there was an average decrease in the VLF (50%) and LF bands (63%). Diabetics with poor glycemic control had a higher average VLF/LF (49%) than diabetics with good glycemic control. No significant changes at p < 0.05 were observed in high‐frequency (HF) frequency domain parameters or their ratios, or in the time domain. Fetuses of pregestational diabetic mothers exhibited some differences in fHRV frequency domain and heart rate‐movement coupling when compared to non‐diabetics but the effect of fHRV related to fetal ANS and sympathovagal balance were not as conclusive as observed in the neonates of pregestational diabetic mothers.https://doi.org/10.14814/phy2.15680autonomic nervous systemfetusheart rate variabilitymagnetocardiographyneurodevelopmentpregestational diabetes |
| spellingShingle | Luis Mercado Diana Escalona‐Vargas Sarah Blossom Eric R. Siegel Julie R. Whittington Hubert Preissl Kaitlyn Walden Hari Eswaran The effect of maternal pregestational diabetes on fetal autonomic nervous system Physiological Reports autonomic nervous system fetus heart rate variability magnetocardiography neurodevelopment pregestational diabetes |
| title | The effect of maternal pregestational diabetes on fetal autonomic nervous system |
| title_full | The effect of maternal pregestational diabetes on fetal autonomic nervous system |
| title_fullStr | The effect of maternal pregestational diabetes on fetal autonomic nervous system |
| title_full_unstemmed | The effect of maternal pregestational diabetes on fetal autonomic nervous system |
| title_short | The effect of maternal pregestational diabetes on fetal autonomic nervous system |
| title_sort | effect of maternal pregestational diabetes on fetal autonomic nervous system |
| topic | autonomic nervous system fetus heart rate variability magnetocardiography neurodevelopment pregestational diabetes |
| url | https://doi.org/10.14814/phy2.15680 |
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