2-Styrylchromones Prevent IL-1β-Induced Pro-Inflammatory Activation of Fibroblast-like Synoviocytes while Increasing COX-2 Expression

2-Styrylchromones Prevent IL-1β-Induced Pro-Inflammatory Activation of Fibroblast-like Synoviocytes while Increasing COX-2 Expression

Rheumatoid arthritis (RA) is characterized by systemic immune and chronic inflammatory features, leading to the destruction of the joints. Presently, there are no effective drugs able to control synovitis and catabolism in the process of RA. 2-Styrylchromones (2-SC) are a small group of compounds ch...

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Bibliographic Details
Main Authors: Ana Teresa Rufino, Mariana Lucas, Artur M. S. Silva, Daniela Ribeiro, Eduarda Fernandes
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
2-Styrylchromones
rheumatoid arthritis
fibroblast-like synoviocytes
inflammation
NF-kB
COX-2
Online Access:https://www.mdpi.com/1999-4923/15/3/780

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