Unraveling Extremely Damaging <i>IRAK4</i> Variants and Their Potential Implications for IRAK4 Inhibitor Efficacy

Unraveling Extremely Damaging <i>IRAK4</i> Variants and Their Potential Implications for IRAK4 Inhibitor Efficacy

Interleukin-1-receptor-associated kinase 4 (IRAK4) possesses a crucial function in the toll-like receptor (TLR) signaling pathway, and the dysfunction of this molecule could lead to various infectious and immune-related diseases in addition to cancers. <i>IRAK4</i> genetic variants have...

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Bibliographic Details
Main Authors: Mohammed Y. Behairy, Refaat A. Eid, Hassan M. Otifi, Heitham M. Mohammed, Mohammed A. Alshehri, Ashwag Asiri, Majed Aldehri, Mohamed Samir A. Zaki, Khaled M. Darwish, Sameh S. Elhady, Nahla H. El-Shaer, Muhammad Alaa Eldeen
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Journal of Personalized Medicine
Subjects:
innate immunity
SNPs
bioinformatics
molecular dynamics
TLR signaling
Online Access:https://www.mdpi.com/2075-4426/13/12/1648

Internet

https://www.mdpi.com/2075-4426/13/12/1648

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