Spermidine treatment: induction of autophagy but also apoptosis?

Spermidine treatment: induction of autophagy but also apoptosis?

Abstract Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis. It is caused by the autosomal dominant inheritance of a long CAG trinucleotide repeat sequenc...

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Bibliographic Details
Main Authors: Maxinne Watchon, Amanda L. Wright, Holly I. Ahel, Katherine J. Robinson, Stuart K. Plenderleith, Andrea Kuriakose, Kristy C. Yuan, Angela S. Laird
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Molecular Brain
Subjects:
Machado-Joseph disease
Neurodegeneration
PolyQ
Spinocerebellar ataxia type 3
Autophagy
Zebrafish
Online Access:https://doi.org/10.1186/s13041-024-01085-7

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