The role of cytokines in bone remodeling and the pathogenesis of postmenopausal osteoporosis
About 20 years ago osteoimmunology was identified as new field of scientific knowledge. It studies patterns of immune and bone system interactions in normal and pathological conditions. The osteoimmunology achievements have fundamentally changed our ideas about the pathogenesis of human skeleton dis...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2020-06-01
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| Series: | Медицинский вестник Юга России |
| Subjects: | |
| Online Access: | https://www.medicalherald.ru/jour/article/view/1062 |
| Summary: | About 20 years ago osteoimmunology was identified as new field of scientific knowledge. It studies patterns of immune and bone system interactions in normal and pathological conditions. The osteoimmunology achievements have fundamentally changed our ideas about the pathogenesis of human skeleton diseases, including osteoporosis. This review presents cytokines key role in physiological and pathological bone remodeling. The issues of interaction between cytokines, osteoblasts and osteoclasts are described in detail. The crucial role of proinflammatory cytokines increased production by immunocompetent cells in the postmenopausal osteoporosis development has been characterized. Pubmed, Scopus, Web of Science, MedLine, eLIBRARY.RU databases were used for systematic literature search. |
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| ISSN: | 2219-8075 2618-7876 |