NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHY
Diabetic retinopathy is major cause of visual impairment and blindness in diabetic patients worldwide. The concept of diabetic retinopathy as vascular disease has established into not only microvascular complication but also neurodegeneration problems. Neurodegeneration plays an important role in pa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2022-01-01
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| Series: | Malang Neurology Journal |
| Subjects: | |
| Online Access: | https://mnj.ub.ac.id/index.php/mnj/article/view/589 |
| _version_ | 1797740450070659072 |
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| author | Nadia Artha Dewi Muhammad Arfan Herisa Rahmasari Mutiara Kristiani Putri Rulli Rosandi Shahdevi Nandar Kurniawan |
| author_facet | Nadia Artha Dewi Muhammad Arfan Herisa Rahmasari Mutiara Kristiani Putri Rulli Rosandi Shahdevi Nandar Kurniawan |
| author_sort | Nadia Artha Dewi |
| collection | DOAJ |
| description | Diabetic retinopathy is major cause of visual impairment and blindness in diabetic patients worldwide. The concept of diabetic retinopathy as vascular disease has established into not only microvascular complication but also neurodegeneration problems. Neurodegeneration plays an important role in pathogenesis of diabetic retinopathy. In fact, neuroretinal changes in diabetes can take place even before vasculopathy can be clinically detected. This condition is marked by accelerated loss of neurons due to apoptosis, particularly in the inner retinal layer. The characteristic of neurodegeneration can be detected through retinal imaging and electrodiagnostics. This review is very crucial, because identifying the pathophysiology of diabetic neurodegeneration better, we may be able to provide interventions using the appropriate therapy. We may also be able to utilize these diagnostic tools for early detections of diabetic retinopathy, thus preventing blindness due to diabetes. |
| first_indexed | 2024-03-12T14:12:37Z |
| format | Article |
| id | doaj.art-6f521441b2f94b0e8e68080fdd19d8e7 |
| institution | Directory Open Access Journal |
| issn | 2407-6724 2442-5001 |
| language | English |
| last_indexed | 2024-03-12T14:12:37Z |
| publishDate | 2022-01-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Malang Neurology Journal |
| spelling | doaj.art-6f521441b2f94b0e8e68080fdd19d8e72023-08-21T05:47:48ZengUniversity of BrawijayaMalang Neurology Journal2407-67242442-50012022-01-0181586310.21776/ub.mnj.2022.008.01.12384NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHYNadia Artha Dewi0Muhammad Arfan1Herisa Rahmasari2Mutiara Kristiani Putri3Rulli Rosandi4Shahdevi Nandar Kurniawan5Department of Ophthalmology,Medical Faculty Universitas Brawijaya,Saiful Anwar General HospitalDepartment of Ophthalmology,Medical Faculty Universitas Brawijaya,Saiful Anwar General HospitalDepartment of Ophthalmology,Medical Faculty Universitas Brawijaya,Saiful Anwar General HospitalDepartment of Ophthalmology,Medical Faculty Universitas Brawijaya,Saiful Anwar General HospitalDepartment of Internal Medicine, Medical Faculty Universitas Brawijaya,Saiful Anwar General HospitalDepartment of Neurology, Medical Faculty Universitas Brawijaya,Saiful Anwar General HospitalDiabetic retinopathy is major cause of visual impairment and blindness in diabetic patients worldwide. The concept of diabetic retinopathy as vascular disease has established into not only microvascular complication but also neurodegeneration problems. Neurodegeneration plays an important role in pathogenesis of diabetic retinopathy. In fact, neuroretinal changes in diabetes can take place even before vasculopathy can be clinically detected. This condition is marked by accelerated loss of neurons due to apoptosis, particularly in the inner retinal layer. The characteristic of neurodegeneration can be detected through retinal imaging and electrodiagnostics. This review is very crucial, because identifying the pathophysiology of diabetic neurodegeneration better, we may be able to provide interventions using the appropriate therapy. We may also be able to utilize these diagnostic tools for early detections of diabetic retinopathy, thus preventing blindness due to diabetes.https://mnj.ub.ac.id/index.php/mnj/article/view/589neurodegenerationdiabetic retinopathyneurovascular unitretinal nerve fiber layerreview |
| spellingShingle | Nadia Artha Dewi Muhammad Arfan Herisa Rahmasari Mutiara Kristiani Putri Rulli Rosandi Shahdevi Nandar Kurniawan NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHY Malang Neurology Journal neurodegeneration diabetic retinopathy neurovascular unit retinal nerve fiber layer review |
| title | NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHY |
| title_full | NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHY |
| title_fullStr | NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHY |
| title_full_unstemmed | NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHY |
| title_short | NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHY |
| title_sort | neurodegeneration as an early sign of diabetic retinopathy |
| topic | neurodegeneration diabetic retinopathy neurovascular unit retinal nerve fiber layer review |
| url | https://mnj.ub.ac.id/index.php/mnj/article/view/589 |
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