Crataegus monogyna Aqueous Extract Ameliorates Cyclophosphamide-Induced Toxicity in Rat Testis: Stereological Evidences
Cyclophosphamide (CP) is extensively used as an antineoplastic agent for the treatment of various cancers, as well as an immunosuppressive agent. However, despite its wide spectrum of clinical uses, CP is known to cause several adverse effects including reproductive toxicity. Crataegus monogyna is o...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2012-01-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/3850 |
| _version_ | 1819087503827664896 |
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| author | Ali Shalizar Jalali Shapour Hasanzadeh Hassan Malekinejad |
| author_facet | Ali Shalizar Jalali Shapour Hasanzadeh Hassan Malekinejad |
| author_sort | Ali Shalizar Jalali |
| collection | DOAJ |
| description | Cyclophosphamide (CP) is extensively used as an antineoplastic agent for the treatment of various cancers, as well as an immunosuppressive agent. However, despite its wide spectrum of clinical uses, CP is known to cause several adverse effects including reproductive toxicity. Crataegus monogyna is one of the oldest pharmaceutical plants that have been shown to be cytoprotective by scavenging free radicals. The present study was conducted to assess whether Crataegus monogyna fruits aqueous extract with anti-oxidant properties, could serve as a protective agent against reproductive toxicity during CP treatment in a rat model. Male Wistar rats were categorized into four groups. Two groups of rats were administered CP at a dose of 5 mg in 5 ml saline/kg/day for 28 days by oral gavages. One of these groups received Crataegus monogyna aqueous extract at a dose of 20 mg/kg/day orally four hours after cyclophosphamide administration. A vehicle treated control group and a Crataegus monogyna control group were also included. The CP-treated group showed significant decreases in the body, testes and epididymides weights as well as many histological alterations. Stereological parameters and spermatogenic activities (Sertoli cell, repopulation and miotic indices) were also significantly decreased by CP treatment. Notably, Crataegus coadministration caused a partial recovery in above-mentined parameters. These findings indicate that Crataegus monogyna may be partially protective against CP-induced testicular toxicity. |
| first_indexed | 2024-12-21T21:37:11Z |
| format | Article |
| id | doaj.art-6f54f0040364450ab9de63880b575b59 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-21T21:37:11Z |
| publishDate | 2012-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-6f54f0040364450ab9de63880b575b592022-12-21T18:49:26ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942012-01-01501Crataegus monogyna Aqueous Extract Ameliorates Cyclophosphamide-Induced Toxicity in Rat Testis: Stereological EvidencesAli Shalizar Jalali0Shapour Hasanzadeh1Hassan Malekinejad2Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.Cyclophosphamide (CP) is extensively used as an antineoplastic agent for the treatment of various cancers, as well as an immunosuppressive agent. However, despite its wide spectrum of clinical uses, CP is known to cause several adverse effects including reproductive toxicity. Crataegus monogyna is one of the oldest pharmaceutical plants that have been shown to be cytoprotective by scavenging free radicals. The present study was conducted to assess whether Crataegus monogyna fruits aqueous extract with anti-oxidant properties, could serve as a protective agent against reproductive toxicity during CP treatment in a rat model. Male Wistar rats were categorized into four groups. Two groups of rats were administered CP at a dose of 5 mg in 5 ml saline/kg/day for 28 days by oral gavages. One of these groups received Crataegus monogyna aqueous extract at a dose of 20 mg/kg/day orally four hours after cyclophosphamide administration. A vehicle treated control group and a Crataegus monogyna control group were also included. The CP-treated group showed significant decreases in the body, testes and epididymides weights as well as many histological alterations. Stereological parameters and spermatogenic activities (Sertoli cell, repopulation and miotic indices) were also significantly decreased by CP treatment. Notably, Crataegus coadministration caused a partial recovery in above-mentined parameters. These findings indicate that Crataegus monogyna may be partially protective against CP-induced testicular toxicity.https://acta.tums.ac.ir/index.php/acta/article/view/3850Crataegus monogynaCyclophosphamideToxicityTestis |
| spellingShingle | Ali Shalizar Jalali Shapour Hasanzadeh Hassan Malekinejad Crataegus monogyna Aqueous Extract Ameliorates Cyclophosphamide-Induced Toxicity in Rat Testis: Stereological Evidences Acta Medica Iranica Crataegus monogyna Cyclophosphamide Toxicity Testis |
| title | Crataegus monogyna Aqueous Extract Ameliorates Cyclophosphamide-Induced Toxicity in Rat Testis: Stereological Evidences |
| title_full | Crataegus monogyna Aqueous Extract Ameliorates Cyclophosphamide-Induced Toxicity in Rat Testis: Stereological Evidences |
| title_fullStr | Crataegus monogyna Aqueous Extract Ameliorates Cyclophosphamide-Induced Toxicity in Rat Testis: Stereological Evidences |
| title_full_unstemmed | Crataegus monogyna Aqueous Extract Ameliorates Cyclophosphamide-Induced Toxicity in Rat Testis: Stereological Evidences |
| title_short | Crataegus monogyna Aqueous Extract Ameliorates Cyclophosphamide-Induced Toxicity in Rat Testis: Stereological Evidences |
| title_sort | crataegus monogyna aqueous extract ameliorates cyclophosphamide induced toxicity in rat testis stereological evidences |
| topic | Crataegus monogyna Cyclophosphamide Toxicity Testis |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/3850 |
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