Preparation, characterization, and antitumor activity of Chaenomeles speciosa polysaccharide-based selenium nanoparticles
Nanoparticles have been found to possess unique advantages in many fields, especially in the field of cancer treatment. Herein, based on the unique physical and chemical properties of natural polysaccharides, the polysaccharide from the edible and medicinal fruits of Chaenomeles speciosa was prepare...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535222002593 |
| _version_ | 1828336528389046272 |
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| author | Linan Zhou Yeling Li Xiaotang Gong Zhengguo Li Honglin Wang Lingling Ma Muhetaer Tuerhong Munira Abudukeremu Yasushi Ohizumi Jing Xu Yuanqiang Guo |
| author_facet | Linan Zhou Yeling Li Xiaotang Gong Zhengguo Li Honglin Wang Lingling Ma Muhetaer Tuerhong Munira Abudukeremu Yasushi Ohizumi Jing Xu Yuanqiang Guo |
| author_sort | Linan Zhou |
| collection | DOAJ |
| description | Nanoparticles have been found to possess unique advantages in many fields, especially in the field of cancer treatment. Herein, based on the unique physical and chemical properties of natural polysaccharides, the polysaccharide from the edible and medicinal fruits of Chaenomeles speciosa was prepared, and the complex nanoparticles constructed by combining C. speciosa polysaccharide with selenium have been successfully developed by a chemical method. Monodisperse spherical nanoparticles with the particle size of 80.5 nm were characterized by various methods, which exhibited ideal size distribution and prominent stability under physiological conditions and alkaline conditions. Cellular studies demonstrated the nanoparticles significantly inhibited the growth of MCF-7 cells with an IC50 value of 8.37 ± 0.97 μg/mL through inducing the apoptosis and arresting the cell circle at S phase. Moreover, the zebrafish assays confirmed the antitumor effects of the nanoparticles, which suppressed the proliferation and migration of tumor and blocked the angiogenesis of transgenic zebrafish. Collectively, the results suggested that the nanoparticles may be considered as a candidate agent to treat breast cancer. |
| first_indexed | 2024-04-13T22:02:05Z |
| format | Article |
| id | doaj.art-6f559398bf8a4344b4c45e0de1866488 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-13T22:02:05Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-6f559398bf8a4344b4c45e0de18664882022-12-22T02:28:03ZengElsevierArabian Journal of Chemistry1878-53522022-08-01158103943Preparation, characterization, and antitumor activity of Chaenomeles speciosa polysaccharide-based selenium nanoparticlesLinan Zhou0Yeling Li1Xiaotang Gong2Zhengguo Li3Honglin Wang4Lingling Ma5Muhetaer Tuerhong6Munira Abudukeremu7Yasushi Ohizumi8Jing Xu9Yuanqiang Guo10State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaCollege of Chemistry and Environmental Sciences, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashgar University, Kashgar 844000, People’s Republic of ChinaCollege of Chemistry and Environmental Sciences, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashgar University, Kashgar 844000, People’s Republic of ChinaKansei Fukushi Research Institute, Tohoku Fukushi University, Sendai 989-3201, JapanState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of China; Corresponding authors.State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of China; Corresponding authors.Nanoparticles have been found to possess unique advantages in many fields, especially in the field of cancer treatment. Herein, based on the unique physical and chemical properties of natural polysaccharides, the polysaccharide from the edible and medicinal fruits of Chaenomeles speciosa was prepared, and the complex nanoparticles constructed by combining C. speciosa polysaccharide with selenium have been successfully developed by a chemical method. Monodisperse spherical nanoparticles with the particle size of 80.5 nm were characterized by various methods, which exhibited ideal size distribution and prominent stability under physiological conditions and alkaline conditions. Cellular studies demonstrated the nanoparticles significantly inhibited the growth of MCF-7 cells with an IC50 value of 8.37 ± 0.97 μg/mL through inducing the apoptosis and arresting the cell circle at S phase. Moreover, the zebrafish assays confirmed the antitumor effects of the nanoparticles, which suppressed the proliferation and migration of tumor and blocked the angiogenesis of transgenic zebrafish. Collectively, the results suggested that the nanoparticles may be considered as a candidate agent to treat breast cancer.http://www.sciencedirect.com/science/article/pii/S1878535222002593Selenium nanoparticlesAntitumorChaenomeles speciosa polysaccharideZebrafish |
| spellingShingle | Linan Zhou Yeling Li Xiaotang Gong Zhengguo Li Honglin Wang Lingling Ma Muhetaer Tuerhong Munira Abudukeremu Yasushi Ohizumi Jing Xu Yuanqiang Guo Preparation, characterization, and antitumor activity of Chaenomeles speciosa polysaccharide-based selenium nanoparticles Arabian Journal of Chemistry Selenium nanoparticles Antitumor Chaenomeles speciosa polysaccharide Zebrafish |
| title | Preparation, characterization, and antitumor activity of Chaenomeles speciosa polysaccharide-based selenium nanoparticles |
| title_full | Preparation, characterization, and antitumor activity of Chaenomeles speciosa polysaccharide-based selenium nanoparticles |
| title_fullStr | Preparation, characterization, and antitumor activity of Chaenomeles speciosa polysaccharide-based selenium nanoparticles |
| title_full_unstemmed | Preparation, characterization, and antitumor activity of Chaenomeles speciosa polysaccharide-based selenium nanoparticles |
| title_short | Preparation, characterization, and antitumor activity of Chaenomeles speciosa polysaccharide-based selenium nanoparticles |
| title_sort | preparation characterization and antitumor activity of chaenomeles speciosa polysaccharide based selenium nanoparticles |
| topic | Selenium nanoparticles Antitumor Chaenomeles speciosa polysaccharide Zebrafish |
| url | http://www.sciencedirect.com/science/article/pii/S1878535222002593 |
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