Removal of lamivudine from synthetic solution using jamun seed (Syzygium cumini) biochar adsorbent
Antiviral drugs such as lamivudine have been globally identified in the environment and marked as emerging pollutants of concern due to their bioactive extremity. Following therapeutic uses, approximately 70% of the oral dose of lamivudine is eliminated renally as the parent drug. Concerns has been...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Emerging Contaminants |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405665023000306 |
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| author | Asha Ripanda Mwemezi J. Rwiza Elias Charles Nyanza Ramadhani Bakari Hossein Miraji Karoli N. Njau Said Ali Hamad Vuai Revocatus L. Machunda |
| author_facet | Asha Ripanda Mwemezi J. Rwiza Elias Charles Nyanza Ramadhani Bakari Hossein Miraji Karoli N. Njau Said Ali Hamad Vuai Revocatus L. Machunda |
| author_sort | Asha Ripanda |
| collection | DOAJ |
| description | Antiviral drugs such as lamivudine have been globally identified in the environment and marked as emerging pollutants of concern due to their bioactive extremity. Following therapeutic uses, approximately 70% of the oral dose of lamivudine is eliminated renally as the parent drug. Concerns has been raised for neighbouring aquatic bodies due to effluent produced from production plants containing high concentrations of antiviral drugs. Antiviral drugs, such as lamivudine, are extremely bioactive, prompting interest in their urgent removal from the environment. The purpose of the present study was to optimize the removal of lamivudine from the synthetic solution using jamun seed (JS) (Syzygium cumini) biochar. The influence of sorption parameters such as pH, lamivudine concentration, adsorbent dosage, contact time, and calcination temperatures on the removal of lamivudine was investigated and optimized using a response surface methodology (SRM) based on optimal design. The results indicated that, a quadratic model best fits data with a model regression coefficient R2, adjusted R2, and predicted R2 of 0.9934, 0.9761 and 0.8340, respectively. The JS biochar calcined at 750 °C, at pH 8, initial lamivudine concentration of 10 ppm and contact time of 30 min indicated a maximum experimental removal efficiency of 84.9%. The residual standard error (RSE) value was 3.5% implying that the model was reliable. Isotherm data for the adsorption of lamivudine on JS biochar followed the Freundlich isotherm, with an R2 value of 0.9977 while R2 for the modified Langmuir model was 0.9852. These findings indicated that JS biochar is potentially useful for removal of lamivudine, and other organics from contaminated water and wastewater effluents. Therefore, this study presents an environmentally friendly remedy against lamivudine for a healthier ecology. |
| first_indexed | 2024-03-11T18:27:56Z |
| format | Article |
| id | doaj.art-6f56b624934a4ec4a2e63e1b2aacf56a |
| institution | Directory Open Access Journal |
| issn | 2405-6650 |
| language | English |
| last_indexed | 2024-03-11T18:27:56Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Emerging Contaminants |
| spelling | doaj.art-6f56b624934a4ec4a2e63e1b2aacf56a2023-10-13T13:55:07ZengKeAi Communications Co., Ltd.Emerging Contaminants2405-66502023-09-0193100232Removal of lamivudine from synthetic solution using jamun seed (Syzygium cumini) biochar adsorbentAsha Ripanda0Mwemezi J. Rwiza1Elias Charles Nyanza2Ramadhani Bakari3Hossein Miraji4Karoli N. Njau5Said Ali Hamad Vuai6Revocatus L. Machunda7School of Materials, Energy, Water and Environmental Sciences (MEWES), P.O. Box 447, The Nelson Mandela African Institution of Science and Technology (NM-AIST), Tengeru, Arusha, Tanzania; Department of Chemistry, College of Natural and Mathematical Sciences, P.O. Box 338, University of Dodoma, Dodoma, Tanzania; Corresponding author. School of Materials, Energy, Water and Environmental Sciences (MEWES), P.O. Box 447, The Nelson Mandela African Institution of Science and Technology (NM-AIST), Tengeru, Arusha, Tanzania.School of Materials, Energy, Water and Environmental Sciences (MEWES), P.O. Box 447, The Nelson Mandela African Institution of Science and Technology (NM-AIST), Tengeru, Arusha, TanzaniaDepartment of Environmental and Occupational Health, School of Public Health, Catholic University of Health and Allied Sciences (CUHAS), 1464, Mwanza, TanzaniaDepartment of Petroleum and Energy Engineering, The University of Dodoma, P.O Box 11090, Dodoma, TanzaniaDepartment of Chemistry, College of Natural and Mathematical Sciences, P.O. Box 338, University of Dodoma, Dodoma, TanzaniaSchool of Materials, Energy, Water and Environmental Sciences (MEWES), P.O. Box 447, The Nelson Mandela African Institution of Science and Technology (NM-AIST), Tengeru, Arusha, TanzaniaDepartment of Chemistry, College of Natural and Mathematical Sciences, P.O. Box 338, University of Dodoma, Dodoma, TanzaniaSchool of Materials, Energy, Water and Environmental Sciences (MEWES), P.O. Box 447, The Nelson Mandela African Institution of Science and Technology (NM-AIST), Tengeru, Arusha, TanzaniaAntiviral drugs such as lamivudine have been globally identified in the environment and marked as emerging pollutants of concern due to their bioactive extremity. Following therapeutic uses, approximately 70% of the oral dose of lamivudine is eliminated renally as the parent drug. Concerns has been raised for neighbouring aquatic bodies due to effluent produced from production plants containing high concentrations of antiviral drugs. Antiviral drugs, such as lamivudine, are extremely bioactive, prompting interest in their urgent removal from the environment. The purpose of the present study was to optimize the removal of lamivudine from the synthetic solution using jamun seed (JS) (Syzygium cumini) biochar. The influence of sorption parameters such as pH, lamivudine concentration, adsorbent dosage, contact time, and calcination temperatures on the removal of lamivudine was investigated and optimized using a response surface methodology (SRM) based on optimal design. The results indicated that, a quadratic model best fits data with a model regression coefficient R2, adjusted R2, and predicted R2 of 0.9934, 0.9761 and 0.8340, respectively. The JS biochar calcined at 750 °C, at pH 8, initial lamivudine concentration of 10 ppm and contact time of 30 min indicated a maximum experimental removal efficiency of 84.9%. The residual standard error (RSE) value was 3.5% implying that the model was reliable. Isotherm data for the adsorption of lamivudine on JS biochar followed the Freundlich isotherm, with an R2 value of 0.9977 while R2 for the modified Langmuir model was 0.9852. These findings indicated that JS biochar is potentially useful for removal of lamivudine, and other organics from contaminated water and wastewater effluents. Therefore, this study presents an environmentally friendly remedy against lamivudine for a healthier ecology.http://www.sciencedirect.com/science/article/pii/S2405665023000306Syzygium cuminiSynthetic solutionLamivudineJamun seed biocharBiosorbentsEnvironmental contamination |
| spellingShingle | Asha Ripanda Mwemezi J. Rwiza Elias Charles Nyanza Ramadhani Bakari Hossein Miraji Karoli N. Njau Said Ali Hamad Vuai Revocatus L. Machunda Removal of lamivudine from synthetic solution using jamun seed (Syzygium cumini) biochar adsorbent Emerging Contaminants Syzygium cumini Synthetic solution Lamivudine Jamun seed biochar Biosorbents Environmental contamination |
| title | Removal of lamivudine from synthetic solution using jamun seed (Syzygium cumini) biochar adsorbent |
| title_full | Removal of lamivudine from synthetic solution using jamun seed (Syzygium cumini) biochar adsorbent |
| title_fullStr | Removal of lamivudine from synthetic solution using jamun seed (Syzygium cumini) biochar adsorbent |
| title_full_unstemmed | Removal of lamivudine from synthetic solution using jamun seed (Syzygium cumini) biochar adsorbent |
| title_short | Removal of lamivudine from synthetic solution using jamun seed (Syzygium cumini) biochar adsorbent |
| title_sort | removal of lamivudine from synthetic solution using jamun seed syzygium cumini biochar adsorbent |
| topic | Syzygium cumini Synthetic solution Lamivudine Jamun seed biochar Biosorbents Environmental contamination |
| url | http://www.sciencedirect.com/science/article/pii/S2405665023000306 |
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