Altered CYP19A1 and CYP3A4 Activities Due to Mutations A115V, T142A, Q153R and P284L in the Human P450 Oxidoreductase

Altered CYP19A1 and CYP3A4 Activities Due to Mutations A115V, T142A, Q153R and P284L in the Human P450 Oxidoreductase

All cytochromes P450s in the endoplasmic reticulum rely on P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause metabolic disorders of steroid hormone biosynthesis and affect certain drug metabolizing P450 activities. We studied mutations A115V, T142A, Q153R identified in...

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Bibliographic Details
Main Authors: Sameer S. Udhane, Shaheena Parween, Norio Kagawa, Amit V. Pandey
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Pharmacology
Subjects:
POR
P450 oxidoreductase
CYP19A1
CYP3A4
polymorphisms
protein–protein interaction
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00580/full

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