The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells
Since the first observations on the existence of neurosteroids in the 1980’s, our understanding of the importance of these endogenous steroids in the control of the central and peripheral nervous system has increased progressively. Although most of the observations were made in neuronal cells, equal...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00103/full |
| _version_ | 1811224747177934848 |
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| author | Alessandro eFaroni Alessandro eFaroni Valerio eMagnaghi |
| author_facet | Alessandro eFaroni Alessandro eFaroni Valerio eMagnaghi |
| author_sort | Alessandro eFaroni |
| collection | DOAJ |
| description | Since the first observations on the existence of neurosteroids in the 1980’s, our understanding of the importance of these endogenous steroids in the control of the central and peripheral nervous system has increased progressively. Although most of the observations were made in neuronal cells, equally important are the effects that neurosteroids exert on glial cells. Among the different classes of neurosteroids acting on glial cells, the progesterone 5α-3α metabolite, allopregnanolone, displays a particular mechanism of action involving primarily the modulation of classic GABA receptors. In this review, we focus our attention on allopregnanolone because its effects on the physiology of glial cells of the central and peripheral nervous system are intriguing and could potentially lead to the development of new strategies for neuroprotection and/or regeneration of injured nervous tissues. |
| first_indexed | 2024-04-12T08:54:06Z |
| format | Article |
| id | doaj.art-6f59a6f0c629436eb12c993bd0285a2d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T08:54:06Z |
| publishDate | 2011-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6f59a6f0c629436eb12c993bd0285a2d2022-12-22T03:39:28ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922011-12-01210.3389/fendo.2011.0010312813The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cellsAlessandro eFaroni0Alessandro eFaroni1Valerio eMagnaghi2The University of ManchesterUniversità Degli Studi di MilanoUniversità Degli Studi di MilanoSince the first observations on the existence of neurosteroids in the 1980’s, our understanding of the importance of these endogenous steroids in the control of the central and peripheral nervous system has increased progressively. Although most of the observations were made in neuronal cells, equally important are the effects that neurosteroids exert on glial cells. Among the different classes of neurosteroids acting on glial cells, the progesterone 5α-3α metabolite, allopregnanolone, displays a particular mechanism of action involving primarily the modulation of classic GABA receptors. In this review, we focus our attention on allopregnanolone because its effects on the physiology of glial cells of the central and peripheral nervous system are intriguing and could potentially lead to the development of new strategies for neuroprotection and/or regeneration of injured nervous tissues.http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00103/fullGABAmyelinneuron-glia interactionNon-genomic actionSchwann cell |
| spellingShingle | Alessandro eFaroni Alessandro eFaroni Valerio eMagnaghi The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells Frontiers in Endocrinology GABA myelin neuron-glia interaction Non-genomic action Schwann cell |
| title | The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells |
| title_full | The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells |
| title_fullStr | The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells |
| title_full_unstemmed | The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells |
| title_short | The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells |
| title_sort | neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells |
| topic | GABA myelin neuron-glia interaction Non-genomic action Schwann cell |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00103/full |
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