Copper signalling: causes and consequences
Abstract Copper-containing enzymes perform fundamental functions by activating dioxygen (O2) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O2 transport, metabolism and production of signalling molecules are supported by molecular systems that regula...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12964-018-0277-3 |
| _version_ | 1817992658947145728 |
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| author | Julianna Kardos László Héja Ágnes Simon István Jablonkai Richard Kovács Katalin Jemnitz |
| author_facet | Julianna Kardos László Héja Ágnes Simon István Jablonkai Richard Kovács Katalin Jemnitz |
| author_sort | Julianna Kardos |
| collection | DOAJ |
| description | Abstract Copper-containing enzymes perform fundamental functions by activating dioxygen (O2) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O2 transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms. A deeper understanding of of the regulatory effects of copper on neuro-glia coupling via polyamine metabolism may reveal novel copper signalling functions and new directions for therapeutic intervention in brain disorders associated with aberrant copper metabolism. |
| first_indexed | 2024-04-14T01:29:05Z |
| format | Article |
| id | doaj.art-6f59af95637946d39cc8317f85754269 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-14T01:29:05Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-6f59af95637946d39cc8317f857542692022-12-22T02:20:15ZengBMCCell Communication and Signaling1478-811X2018-10-0116112210.1186/s12964-018-0277-3Copper signalling: causes and consequencesJulianna Kardos0László Héja1Ágnes Simon2István Jablonkai3Richard Kovács4Katalin Jemnitz5Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of SciencesFunctional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of SciencesFunctional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of SciencesFunctional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of SciencesInstitute of Neurophysiology, Charité-UniversitätsmedizinFunctional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of SciencesAbstract Copper-containing enzymes perform fundamental functions by activating dioxygen (O2) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O2 transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms. A deeper understanding of of the regulatory effects of copper on neuro-glia coupling via polyamine metabolism may reveal novel copper signalling functions and new directions for therapeutic intervention in brain disorders associated with aberrant copper metabolism.http://link.springer.com/article/10.1186/s12964-018-0277-3Redox disproportionation and speciation of copperDynamic copper poolCopper-rich aggregatesGSH/GSSG ratioCopper chelate therapyNeuro-glia coupling |
| spellingShingle | Julianna Kardos László Héja Ágnes Simon István Jablonkai Richard Kovács Katalin Jemnitz Copper signalling: causes and consequences Cell Communication and Signaling Redox disproportionation and speciation of copper Dynamic copper pool Copper-rich aggregates GSH/GSSG ratio Copper chelate therapy Neuro-glia coupling |
| title | Copper signalling: causes and consequences |
| title_full | Copper signalling: causes and consequences |
| title_fullStr | Copper signalling: causes and consequences |
| title_full_unstemmed | Copper signalling: causes and consequences |
| title_short | Copper signalling: causes and consequences |
| title_sort | copper signalling causes and consequences |
| topic | Redox disproportionation and speciation of copper Dynamic copper pool Copper-rich aggregates GSH/GSSG ratio Copper chelate therapy Neuro-glia coupling |
| url | http://link.springer.com/article/10.1186/s12964-018-0277-3 |
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