Linking Α to Ω: diverse and dynamic RNA-based mechanisms to regulate gene expression by 5′-to-3′ communication [version 1; referees: 2 approved]
Communication between the 5′ and 3′ ends of a eukaryotic messenger RNA (mRNA) or viral genomic RNA is a ubiquitous and important strategy used to regulate gene expression. Although the canonical interaction between initiation factor proteins at the 5′ end of an mRNA and proteins bound to the polyade...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2016-08-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/5-2037/v1 |
| _version_ | 1818541451785535488 |
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| author | Megan E. Filbin Jeffrey S. Kieft |
| author_facet | Megan E. Filbin Jeffrey S. Kieft |
| author_sort | Megan E. Filbin |
| collection | DOAJ |
| description | Communication between the 5′ and 3′ ends of a eukaryotic messenger RNA (mRNA) or viral genomic RNA is a ubiquitous and important strategy used to regulate gene expression. Although the canonical interaction between initiation factor proteins at the 5′ end of an mRNA and proteins bound to the polyadenylate tail at the 3′ end is well known, in fact there are many other strategies used in diverse ways. These strategies can involve “non-canonical” proteins, RNA structures, and direct RNA-RNA base-pairing between distal elements to achieve 5′-to-3′ communication. Likewise, the communication induced by these interactions influences a variety of processes linked to the use and fate of the RNA that contains them. Recent studies are revealing how dynamic these interactions are, possibly changing in response to cellular conditions or to link various phases of the mRNA’s life, from translation to decay. Thus, 5′-to-3′ communication is about more than just making a closed circle; the RNA elements and associated proteins are key players in controlling gene expression at the post-transcriptional level. |
| first_indexed | 2024-12-11T22:09:28Z |
| format | Article |
| id | doaj.art-6f59e260b86f46b1ad78a1c4a8c9c174 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T22:09:28Z |
| publishDate | 2016-08-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-6f59e260b86f46b1ad78a1c4a8c9c1742022-12-22T00:48:50ZengF1000 Research LtdF1000Research2046-14022016-08-01510.12688/f1000research.7913.18518Linking Α to Ω: diverse and dynamic RNA-based mechanisms to regulate gene expression by 5′-to-3′ communication [version 1; referees: 2 approved]Megan E. Filbin0Jeffrey S. Kieft1Department of Chemistry, Metropolitan State University of Denver, Denver, Colorado, 80217, USADepartment of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, Colorado, 80045, USACommunication between the 5′ and 3′ ends of a eukaryotic messenger RNA (mRNA) or viral genomic RNA is a ubiquitous and important strategy used to regulate gene expression. Although the canonical interaction between initiation factor proteins at the 5′ end of an mRNA and proteins bound to the polyadenylate tail at the 3′ end is well known, in fact there are many other strategies used in diverse ways. These strategies can involve “non-canonical” proteins, RNA structures, and direct RNA-RNA base-pairing between distal elements to achieve 5′-to-3′ communication. Likewise, the communication induced by these interactions influences a variety of processes linked to the use and fate of the RNA that contains them. Recent studies are revealing how dynamic these interactions are, possibly changing in response to cellular conditions or to link various phases of the mRNA’s life, from translation to decay. Thus, 5′-to-3′ communication is about more than just making a closed circle; the RNA elements and associated proteins are key players in controlling gene expression at the post-transcriptional level.http://f1000research.com/articles/5-2037/v1Control of Gene ExpressionStructure: RNAStructure: Transcription & Translation |
| spellingShingle | Megan E. Filbin Jeffrey S. Kieft Linking Α to Ω: diverse and dynamic RNA-based mechanisms to regulate gene expression by 5′-to-3′ communication [version 1; referees: 2 approved] F1000Research Control of Gene Expression Structure: RNA Structure: Transcription & Translation |
| title | Linking Α to Ω: diverse and dynamic RNA-based mechanisms to regulate gene expression by 5′-to-3′ communication [version 1; referees: 2 approved] |
| title_full | Linking Α to Ω: diverse and dynamic RNA-based mechanisms to regulate gene expression by 5′-to-3′ communication [version 1; referees: 2 approved] |
| title_fullStr | Linking Α to Ω: diverse and dynamic RNA-based mechanisms to regulate gene expression by 5′-to-3′ communication [version 1; referees: 2 approved] |
| title_full_unstemmed | Linking Α to Ω: diverse and dynamic RNA-based mechanisms to regulate gene expression by 5′-to-3′ communication [version 1; referees: 2 approved] |
| title_short | Linking Α to Ω: diverse and dynamic RNA-based mechanisms to regulate gene expression by 5′-to-3′ communication [version 1; referees: 2 approved] |
| title_sort | linking α to ω diverse and dynamic rna based mechanisms to regulate gene expression by 5 to 3 communication version 1 referees 2 approved |
| topic | Control of Gene Expression Structure: RNA Structure: Transcription & Translation |
| url | http://f1000research.com/articles/5-2037/v1 |
| work_keys_str_mv | AT meganefilbin linkingatoōdiverseanddynamicrnabasedmechanismstoregulategeneexpressionby5to3communicationversion1referees2approved AT jeffreyskieft linkingatoōdiverseanddynamicrnabasedmechanismstoregulategeneexpressionby5to3communicationversion1referees2approved |