DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4
Upon stress, translation of ATF4 is induced by reinitiating ribosomes following translation of short upstream open reading frames (uORFs). Here the authors show that translation re-initiation of ATF4 is mediated by the DENR-MCTS1 complex which acts on uORFs containing certain penultimate codons.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18452-2 |
| _version_ | 1818993746500386816 |
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| author | Jonathan Bohlen Liza Harbrecht Saioa Blanco Katharina Clemm von Hohenberg Kai Fenzl Günter Kramer Bernd Bukau Aurelio A. Teleman |
| author_facet | Jonathan Bohlen Liza Harbrecht Saioa Blanco Katharina Clemm von Hohenberg Kai Fenzl Günter Kramer Bernd Bukau Aurelio A. Teleman |
| author_sort | Jonathan Bohlen |
| collection | DOAJ |
| description | Upon stress, translation of ATF4 is induced by reinitiating ribosomes following translation of short upstream open reading frames (uORFs). Here the authors show that translation re-initiation of ATF4 is mediated by the DENR-MCTS1 complex which acts on uORFs containing certain penultimate codons. |
| first_indexed | 2024-12-20T20:46:57Z |
| format | Article |
| id | doaj.art-6f5c73c82bd545db83b3c936664b634c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:46:57Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6f5c73c82bd545db83b3c936664b634c2022-12-21T19:27:01ZengNature PortfolioNature Communications2041-17232020-09-0111111510.1038/s41467-020-18452-2DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4Jonathan Bohlen0Liza Harbrecht1Saioa Blanco2Katharina Clemm von Hohenberg3Kai Fenzl4Günter Kramer5Bernd Bukau6Aurelio A. Teleman7German Cancer Research Center (DKFZ)German Cancer Research Center (DKFZ)German Cancer Research Center (DKFZ)German Cancer Research Center (DKFZ)German Cancer Research Center (DKFZ)German Cancer Research Center (DKFZ)German Cancer Research Center (DKFZ)German Cancer Research Center (DKFZ)Upon stress, translation of ATF4 is induced by reinitiating ribosomes following translation of short upstream open reading frames (uORFs). Here the authors show that translation re-initiation of ATF4 is mediated by the DENR-MCTS1 complex which acts on uORFs containing certain penultimate codons.https://doi.org/10.1038/s41467-020-18452-2 |
| spellingShingle | Jonathan Bohlen Liza Harbrecht Saioa Blanco Katharina Clemm von Hohenberg Kai Fenzl Günter Kramer Bernd Bukau Aurelio A. Teleman DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4 Nature Communications |
| title | DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4 |
| title_full | DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4 |
| title_fullStr | DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4 |
| title_full_unstemmed | DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4 |
| title_short | DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4 |
| title_sort | denr promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including atf4 |
| url | https://doi.org/10.1038/s41467-020-18452-2 |
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