Prevalence of Hepatitis B virus genotypes in HBsAg positive individuals of Afghanistan
<p>Abstract</p> <p>Background</p> <p>The structural and functional differences between hepatitis B virus (HBV) genotypes are the mainstay to severity, complications, treatment and possibly vaccination against the virus. This study was conducted to determine the HBV geno...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-06-01
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| Series: | Virology Journal |
| Online Access: | http://www.virologyj.com/content/8/1/281 |
| _version_ | 1811299341212581888 |
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| author | Ali Sajid Ali Ijaz Khan Sanaullah Rehman Saif ur Attaullah Sobia Khan Shahid |
| author_facet | Ali Sajid Ali Ijaz Khan Sanaullah Rehman Saif ur Attaullah Sobia Khan Shahid |
| author_sort | Ali Sajid |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The structural and functional differences between hepatitis B virus (HBV) genotypes are the mainstay to severity, complications, treatment and possibly vaccination against the virus. This study was conducted to determine the HBV genotypes in HBsAg positive patients of Afghanistan as no such large scale data available previously.</p> <p>Methods</p> <p>Two hundred and fourteen HBsAg-positive patients were included in this study. All patients were anti-HCV and anti-HIV negative. All the samples were confirmed for HBV DNA with nested PCR while HBV DNA positive samples were subjected to type specific PCR for HBV genotyping (A-F).</p> <p>Results</p> <p>Of the total samples, 168 (78.5%) were males and 46 (21.49%) females, aged ranged between 18 to 71 years. This study demonstrated that genotype D (35.67%) is the predominant genotype circulating in Afghani's population. Genotype C was observed in 32.16% followed by genotype A (19.30%), and genotype B (7.02%) while 6.07% of the individuals were not typed.</p> <p>Conclusion</p> <p>This study has shown a heterogeneous distribution of HBV genotypes. Further more, extensive studies are required to investigate genetic and geographical divergence and characteristics of the virus in the country, as no such large sample sized study has been carried out so far in this country.</p> |
| first_indexed | 2024-04-13T06:33:43Z |
| format | Article |
| id | doaj.art-6f5cf6dcdb0a4954b2e88cc7b2bd5575 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-13T06:33:43Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-6f5cf6dcdb0a4954b2e88cc7b2bd55752022-12-22T02:58:00ZengBMCVirology Journal1743-422X2011-06-018128110.1186/1743-422X-8-281Prevalence of Hepatitis B virus genotypes in HBsAg positive individuals of AfghanistanAli SajidAli IjazKhan SanaullahRehman Saif urAttaullah SobiaKhan Shahid<p>Abstract</p> <p>Background</p> <p>The structural and functional differences between hepatitis B virus (HBV) genotypes are the mainstay to severity, complications, treatment and possibly vaccination against the virus. This study was conducted to determine the HBV genotypes in HBsAg positive patients of Afghanistan as no such large scale data available previously.</p> <p>Methods</p> <p>Two hundred and fourteen HBsAg-positive patients were included in this study. All patients were anti-HCV and anti-HIV negative. All the samples were confirmed for HBV DNA with nested PCR while HBV DNA positive samples were subjected to type specific PCR for HBV genotyping (A-F).</p> <p>Results</p> <p>Of the total samples, 168 (78.5%) were males and 46 (21.49%) females, aged ranged between 18 to 71 years. This study demonstrated that genotype D (35.67%) is the predominant genotype circulating in Afghani's population. Genotype C was observed in 32.16% followed by genotype A (19.30%), and genotype B (7.02%) while 6.07% of the individuals were not typed.</p> <p>Conclusion</p> <p>This study has shown a heterogeneous distribution of HBV genotypes. Further more, extensive studies are required to investigate genetic and geographical divergence and characteristics of the virus in the country, as no such large sample sized study has been carried out so far in this country.</p>http://www.virologyj.com/content/8/1/281 |
| spellingShingle | Ali Sajid Ali Ijaz Khan Sanaullah Rehman Saif ur Attaullah Sobia Khan Shahid Prevalence of Hepatitis B virus genotypes in HBsAg positive individuals of Afghanistan Virology Journal |
| title | Prevalence of Hepatitis B virus genotypes in HBsAg positive individuals of Afghanistan |
| title_full | Prevalence of Hepatitis B virus genotypes in HBsAg positive individuals of Afghanistan |
| title_fullStr | Prevalence of Hepatitis B virus genotypes in HBsAg positive individuals of Afghanistan |
| title_full_unstemmed | Prevalence of Hepatitis B virus genotypes in HBsAg positive individuals of Afghanistan |
| title_short | Prevalence of Hepatitis B virus genotypes in HBsAg positive individuals of Afghanistan |
| title_sort | prevalence of hepatitis b virus genotypes in hbsag positive individuals of afghanistan |
| url | http://www.virologyj.com/content/8/1/281 |
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