Estradiol Replacement at the Critical Period Protects Hippocampal Neural Stem Cells to Improve Cognition in APP/PS1 Mice

Estradiol Replacement at the Critical Period Protects Hippocampal Neural Stem Cells to Improve Cognition in APP/PS1 Mice

It has been suggested that there is a critical window for estrogen replacement therapy (ERT) in postmenopausal women with Alzheimer’s disease (AD); however, supporting evidence is lacking. To address this issue, we investigated the effective period for estradiol (E2) treatment using a mouse model of...

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Bibliographic Details
Main Authors: Yaoyao Qin, Dong An, Weixing Xu, Xiuting Qi, Xiaoli Wang, Ling Chen, Lei Chen, Sha Sha
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease (AD)
β-amyloid (Aβ)
estradiol (E2)
hippocampus
neurogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00240/full

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