Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 Diabetes
Islet delivery devices (IDDs) offer potential benefits for islet transplantation and stem cell-based replacement in type 1 diabetes. Little is known about patient preferences regarding islet delivery device characteristics and implantation strategies. Patient preferences for IDDs and implantation st...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Transplant International |
| Subjects: | |
| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2023.11077/full |
| _version_ | 1797220671939411968 |
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| author | Maarten C. Tol Maarten C. Tol Denise F. A. de Bont Wouter P. C. Boon Eelco J. P. de Koning Eelco J. P. de Koning Aart A. van Apeldoorn Aart A. van Apeldoorn |
| author_facet | Maarten C. Tol Maarten C. Tol Denise F. A. de Bont Wouter P. C. Boon Eelco J. P. de Koning Eelco J. P. de Koning Aart A. van Apeldoorn Aart A. van Apeldoorn |
| author_sort | Maarten C. Tol |
| collection | DOAJ |
| description | Islet delivery devices (IDDs) offer potential benefits for islet transplantation and stem cell-based replacement in type 1 diabetes. Little is known about patient preferences regarding islet delivery device characteristics and implantation strategies. Patient preferences for IDDs and implantation strategies remain understudied. We invited patients, parents and caregivers to fill in an online questionnaire regarding IDDs. An online survey gathered responses from 809 type 1 diabetes patients and 47 caregivers. We also assessed diabetes distress in a subgroup of 412 patients. A significant majority (97%) expressed willingness to receive an IDD. Preferred IDD attributes included a 3.5 cm diameter for 37.7% of respondents, while when provided with all options, 30.4% found dimensions unimportant. Respondents were open to approximately 4 implants, each with a 5 cm incision. Many favored a device functioning for 12 months (33.4%) or 24 months (24.8%). Younger participants (16–30) were more inclined to accept a 6 months functional duration (p < 0.001). Functional duration outweighed implant quantity and size (p < 0.001) in device importance. This emphasizes patients’ willingness to accommodate burdens related to IDD features and implantation methods, crucial for designing future beta cell replacement strategies. |
| first_indexed | 2024-04-24T12:53:15Z |
| format | Article |
| id | doaj.art-6f5fd4ff3e1641839101000e06a83df9 |
| institution | Directory Open Access Journal |
| issn | 1432-2277 |
| language | English |
| last_indexed | 2024-04-24T12:53:15Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj.art-6f5fd4ff3e1641839101000e06a83df92024-04-05T16:51:30ZengFrontiers Media S.A.Transplant International1432-22772023-10-013610.3389/ti.2023.1107711077Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 DiabetesMaarten C. Tol0Maarten C. Tol1Denise F. A. de Bont2Wouter P. C. Boon3Eelco J. P. de Koning4Eelco J. P. de Koning5Aart A. van Apeldoorn6Aart A. van Apeldoorn7Department of Internal Medicine, Leiden University Medical Center, Leiden, NetherlandsLUMC Transplant Center, Leiden University Medical Center, Leiden, NetherlandsCell Biology-Inspired Tissue Engineering (cBITE), MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, NetherlandsCopernicus Institute of Sustainable Development, Utrecht University, Utrecht, NetherlandsDepartment of Internal Medicine, Leiden University Medical Center, Leiden, NetherlandsLUMC Transplant Center, Leiden University Medical Center, Leiden, NetherlandsCell Biology-Inspired Tissue Engineering (cBITE), MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, NetherlandsLighthouse Biomedical B.V., Maastricht, NetherlandsIslet delivery devices (IDDs) offer potential benefits for islet transplantation and stem cell-based replacement in type 1 diabetes. Little is known about patient preferences regarding islet delivery device characteristics and implantation strategies. Patient preferences for IDDs and implantation strategies remain understudied. We invited patients, parents and caregivers to fill in an online questionnaire regarding IDDs. An online survey gathered responses from 809 type 1 diabetes patients and 47 caregivers. We also assessed diabetes distress in a subgroup of 412 patients. A significant majority (97%) expressed willingness to receive an IDD. Preferred IDD attributes included a 3.5 cm diameter for 37.7% of respondents, while when provided with all options, 30.4% found dimensions unimportant. Respondents were open to approximately 4 implants, each with a 5 cm incision. Many favored a device functioning for 12 months (33.4%) or 24 months (24.8%). Younger participants (16–30) were more inclined to accept a 6 months functional duration (p < 0.001). Functional duration outweighed implant quantity and size (p < 0.001) in device importance. This emphasizes patients’ willingness to accommodate burdens related to IDD features and implantation methods, crucial for designing future beta cell replacement strategies.https://www.frontierspartnerships.org/articles/10.3389/ti.2023.11077/fullislet transplantationsurveytype 1 diabetesislet delivery devicepatient preference |
| spellingShingle | Maarten C. Tol Maarten C. Tol Denise F. A. de Bont Wouter P. C. Boon Eelco J. P. de Koning Eelco J. P. de Koning Aart A. van Apeldoorn Aart A. van Apeldoorn Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 Diabetes Transplant International islet transplantation survey type 1 diabetes islet delivery device patient preference |
| title | Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 Diabetes |
| title_full | Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 Diabetes |
| title_fullStr | Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 Diabetes |
| title_full_unstemmed | Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 Diabetes |
| title_short | Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 Diabetes |
| title_sort | preferred islet delivery device characteristics and implantation strategies of patients with type 1 diabetes |
| topic | islet transplantation survey type 1 diabetes islet delivery device patient preference |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2023.11077/full |
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