Comparison of serum levels of collagen type I turnover markers in early-onset preeclampsia and healthy pregnant women
Introduction: Collagen type I is a major structural component of human uterus. Recent studies have found that collagen type I turnover is altered in preeclampsia and imbalance occurs between collagen synthesis and degradation processes. This acts as a stimulus for abnormal changes in the concentrati...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2021-08-01
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| Series: | Folia Medica |
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| Online Access: | https://foliamedica.bg/article/60249/download/pdf/ |
| _version_ | 1798023386368049152 |
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| author | Asparuh G. Nikolov Nikola K. Popovski Alexander B. Blazhev Svetla Blazheva |
| author_facet | Asparuh G. Nikolov Nikola K. Popovski Alexander B. Blazhev Svetla Blazheva |
| author_sort | Asparuh G. Nikolov |
| collection | DOAJ |
| description | Introduction: Collagen type I is a major structural component of human uterus. Recent studies have found that collagen type I turnover is altered in preeclampsia and imbalance occurs between collagen synthesis and degradation processes. This acts as a stimulus for abnormal changes in the concentrations of collagen type I derived products in circulating blood.Aim: Having in mind the pathological collagen type I turnover in preeclampisa, the aim of the present study was to determine the levels of N-terminal propeptide of collagen type I (PINP), C-terminal propeptide of collagen type I (PICP): both markers of collagen type I synthesis and levels of matrix metalloproteinase-1 (MMP-1): marker of collagen type I degradation in sera of women with early-onset preeclampsia.Materials and methods: Thirty-two patients with early-onset preeclampsia were examined. The mean age of the patients was 28.8±5.5 years; and the mean age of 22 age-matched healthy pregnant women was 28.5±6.0 years. The enzyme-linked immunosorbent assay (ELISA) was used for measuring serum levels of PINP, PICP and MMP-1.Results: There were no statistically significant differences between levels of PINP, PICP and MMP-1 in the sera of women with preeclampsia and healthy pregnancies: 16.991 (15.41÷21.143) vs. 17.189 (15.805÷20.747) µg/L (KW=0.02; p>0.05), 10.929 (8.7÷13.937) vs. 11.474 (7.369÷11.932) µg/L (KW=0.026; p>0.05), and 2.097 (1.384÷2.923) vs. 2.589 (1.41÷4.533) µg/L (KW=0.238; p>0.05), respectively. There were statistically significantly higher number of patients from the preeclampsia group than healthy pregnant women with BMI≥25 (23/32 vs. 4/22) and abnormal UAD (18/32 vs. 2/22) (p<0.05).Conclusions: Our results did not show significant differences between serum levels of PINP, PICP and MMP-1 (markers of collagen type I turnover) in women with early-onset preeclampsia and healthy pregnancy. Further studies with more specific methods and larger sample size are required to assess changes in the serum levels of PINP, PICP and MMP-1 in early-onset preeclampsia. |
| first_indexed | 2024-04-11T17:45:31Z |
| format | Article |
| id | doaj.art-6f60707aca884a99ac5fad19275b3587 |
| institution | Directory Open Access Journal |
| issn | 1314-2143 |
| language | English |
| last_indexed | 2024-04-11T17:45:31Z |
| publishDate | 2021-08-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Folia Medica |
| spelling | doaj.art-6f60707aca884a99ac5fad19275b35872022-12-22T04:11:23ZengPensoft PublishersFolia Medica1314-21432021-08-0163451952610.3897/folmed.63.e6024960249Comparison of serum levels of collagen type I turnover markers in early-onset preeclampsia and healthy pregnant womenAsparuh G. Nikolov0Nikola K. Popovski1Alexander B. Blazhev2Svetla Blazheva3Medical University of PlevenMedical University of PlevenMedical University of PlevenMedical University of PlevenIntroduction: Collagen type I is a major structural component of human uterus. Recent studies have found that collagen type I turnover is altered in preeclampsia and imbalance occurs between collagen synthesis and degradation processes. This acts as a stimulus for abnormal changes in the concentrations of collagen type I derived products in circulating blood.Aim: Having in mind the pathological collagen type I turnover in preeclampisa, the aim of the present study was to determine the levels of N-terminal propeptide of collagen type I (PINP), C-terminal propeptide of collagen type I (PICP): both markers of collagen type I synthesis and levels of matrix metalloproteinase-1 (MMP-1): marker of collagen type I degradation in sera of women with early-onset preeclampsia.Materials and methods: Thirty-two patients with early-onset preeclampsia were examined. The mean age of the patients was 28.8±5.5 years; and the mean age of 22 age-matched healthy pregnant women was 28.5±6.0 years. The enzyme-linked immunosorbent assay (ELISA) was used for measuring serum levels of PINP, PICP and MMP-1.Results: There were no statistically significant differences between levels of PINP, PICP and MMP-1 in the sera of women with preeclampsia and healthy pregnancies: 16.991 (15.41÷21.143) vs. 17.189 (15.805÷20.747) µg/L (KW=0.02; p>0.05), 10.929 (8.7÷13.937) vs. 11.474 (7.369÷11.932) µg/L (KW=0.026; p>0.05), and 2.097 (1.384÷2.923) vs. 2.589 (1.41÷4.533) µg/L (KW=0.238; p>0.05), respectively. There were statistically significantly higher number of patients from the preeclampsia group than healthy pregnant women with BMI≥25 (23/32 vs. 4/22) and abnormal UAD (18/32 vs. 2/22) (p<0.05).Conclusions: Our results did not show significant differences between serum levels of PINP, PICP and MMP-1 (markers of collagen type I turnover) in women with early-onset preeclampsia and healthy pregnancy. Further studies with more specific methods and larger sample size are required to assess changes in the serum levels of PINP, PICP and MMP-1 in early-onset preeclampsia.https://foliamedica.bg/article/60249/download/pdf/extracellular matrixmarkers of collagen type I t |
| spellingShingle | Asparuh G. Nikolov Nikola K. Popovski Alexander B. Blazhev Svetla Blazheva Comparison of serum levels of collagen type I turnover markers in early-onset preeclampsia and healthy pregnant women Folia Medica extracellular matrix markers of collagen type I t |
| title | Comparison of serum levels of collagen type I turnover markers in early-onset preeclampsia and healthy pregnant women |
| title_full | Comparison of serum levels of collagen type I turnover markers in early-onset preeclampsia and healthy pregnant women |
| title_fullStr | Comparison of serum levels of collagen type I turnover markers in early-onset preeclampsia and healthy pregnant women |
| title_full_unstemmed | Comparison of serum levels of collagen type I turnover markers in early-onset preeclampsia and healthy pregnant women |
| title_short | Comparison of serum levels of collagen type I turnover markers in early-onset preeclampsia and healthy pregnant women |
| title_sort | comparison of serum levels of collagen type i turnover markers in early onset preeclampsia and healthy pregnant women |
| topic | extracellular matrix markers of collagen type I t |
| url | https://foliamedica.bg/article/60249/download/pdf/ |
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