Progress in animal models of age-related macular degeneration
Age related macular degeneration(ARMD)is the leading cause of blindness in people over 65 years of age. The need for research on effective treatments of ARMD has led to the development of multiple animal models. ARMD is a complex process involving interaction of age, genetic and environmental factor...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2019-04-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2019/4/201904013.pdf |
| _version_ | 1811215051388878848 |
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| author | Tong-Miao Wang Bo Qin |
| author_facet | Tong-Miao Wang Bo Qin |
| author_sort | Tong-Miao Wang |
| collection | DOAJ |
| description | Age related macular degeneration(ARMD)is the leading cause of blindness in people over 65 years of age. The need for research on effective treatments of ARMD has led to the development of multiple animal models. ARMD is a complex process involving interaction of age, genetic and environmental factors. Animal models have reconstructed many of the histological features in ARMD, making it possible to better understand the underlying pathogenesis of the disease. Although no model can replicate all the phenotypes of human ARMD, it can express different characteristics of ARMD, revealing the roles of chronic oxidative damage, inflammation, immune dysregulation and lipid metabolism in the development of ARMD. This article will review the various ARMD animal models that have been reported. By analyzing the advantages and limitations of each model, it will provide some help for the selection of appropriate animal models for ARMD research and provide new modeling ideas. |
| first_indexed | 2024-04-12T06:14:57Z |
| format | Article |
| id | doaj.art-6f629a04683b4f19857af537410a6063 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-04-12T06:14:57Z |
| publishDate | 2019-04-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-6f629a04683b4f19857af537410a60632022-12-22T03:44:31ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232019-04-0119458659110.3980/j.issn.1672-5123.2019.4.13Progress in animal models of age-related macular degenerationTong-Miao Wang0Bo Qin1Shenzhen University, Shenzhen 518061, Guangdong Province, China; Shenzhen Eye Hospital Affiliated to Jinan UniversityShenzhen Eye Hospital Affiliated to Jinan UniversityAge related macular degeneration(ARMD)is the leading cause of blindness in people over 65 years of age. The need for research on effective treatments of ARMD has led to the development of multiple animal models. ARMD is a complex process involving interaction of age, genetic and environmental factors. Animal models have reconstructed many of the histological features in ARMD, making it possible to better understand the underlying pathogenesis of the disease. Although no model can replicate all the phenotypes of human ARMD, it can express different characteristics of ARMD, revealing the roles of chronic oxidative damage, inflammation, immune dysregulation and lipid metabolism in the development of ARMD. This article will review the various ARMD animal models that have been reported. By analyzing the advantages and limitations of each model, it will provide some help for the selection of appropriate animal models for ARMD research and provide new modeling ideas.http://ies.ijo.cn/cn_publish/2019/4/201904013.pdfrodent modelage-related macular degenerationanimal experiment |
| spellingShingle | Tong-Miao Wang Bo Qin Progress in animal models of age-related macular degeneration Guoji Yanke Zazhi rodent model age-related macular degeneration animal experiment |
| title | Progress in animal models of age-related macular degeneration |
| title_full | Progress in animal models of age-related macular degeneration |
| title_fullStr | Progress in animal models of age-related macular degeneration |
| title_full_unstemmed | Progress in animal models of age-related macular degeneration |
| title_short | Progress in animal models of age-related macular degeneration |
| title_sort | progress in animal models of age related macular degeneration |
| topic | rodent model age-related macular degeneration animal experiment |
| url | http://ies.ijo.cn/cn_publish/2019/4/201904013.pdf |
| work_keys_str_mv | AT tongmiaowang progressinanimalmodelsofagerelatedmaculardegeneration AT boqin progressinanimalmodelsofagerelatedmaculardegeneration |