Photon-counting computed tomography in the assessment of rheumatoid arthritis-associated interstitial lung disease: an initial experience
PURPOSEInterstitial lung disease (ILD) accounts for a significant proportion of mortality and morbidity in patients with rheumatoid arthritis (RA). The aim of this cross-sectional study is to evaluate the performance of novel photon-counting detector computed tomography (PCD-CT) in the detection of...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2023-03-01
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| Series: | Diagnostic and Interventional Radiology |
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http://www.dirjournal.org/archives/archive-detail/article-preview/photon-counting-computed-tomography-in-the-assessm/58822
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| _version_ | 1797691428313235456 |
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| author | Nikolett Marton Janos Gyebnar Kinga Fritsch Judit Majnik Gyorgy Nagy Judit Simon Veronika Müller Adam Domonkos Tarnoki David Laszlo Tarnoki Pal Maurovich-Horvat |
| author_facet | Nikolett Marton Janos Gyebnar Kinga Fritsch Judit Majnik Gyorgy Nagy Judit Simon Veronika Müller Adam Domonkos Tarnoki David Laszlo Tarnoki Pal Maurovich-Horvat |
| author_sort | Nikolett Marton |
| collection | DOAJ |
| description | PURPOSEInterstitial lung disease (ILD) accounts for a significant proportion of mortality and morbidity in patients with rheumatoid arthritis (RA). The aim of this cross-sectional study is to evaluate the performance of novel photon-counting detector computed tomography (PCD-CT) in the detection of pulmonary parenchymal involvement.METHODSSixty-one patients with RA without a previous definitive diagnosis of ILD underwent high-resolution (HR) (0.4 mm slice thickness) and ultra-high-resolution (UHR) (0.2 mm slice thickness) PCDCT examination. The extent of interstitial abnormalities [ground-glass opacity (GGO), reticulation, bronchiectasis, and honeycombing] were scored in each lobe using a Likert-type scale. Total ILD scores were calculated as the sum of scores from all lobes.RESULTSReticulation and bronchiectasis scores were higher in the UHR measurements taken compared with the HR protocol [median (quartile 1, quartile 3): 2 (0, 3.5) vs. 0 (0, 3), P < 0.001 and 2 (0, 2) vs. 0 (0, 2), P < 0.001, respectively]; however, GGO and honeycombing scores did not differ [2 (2, 4) vs. 2 (2, 4), P = 0.944 and 0 (0, 0) vs. 0 (0, 0), P = 0.641, respectively]. Total ILD scores from both HR and UHR scans showed a mild negative correlation in diffusion capacity for carbon monoxide (HR: r = –0.297, P = 0.034; UHR: r = –0.294, P = 0.036). The pattern of lung parenchymal involvement did not differ significantly between the two protocols. The HR protocol had significantly lower volume CT dose index [0.67 (0.69, 1.06) mGy], total dose length product [29 (24.48, 33.2) mGy*cm] compared with UHR scans [8.18 (6.80, 9.23) mGy, P < 0.001 and 250 (218, 305) mGy*cm, P < 0.001].CONCLUSIONUHR PCD-CT provides more detailed information on ILD in patients with RA than low-dose HR PCDCT. HR PCD-CT image acquisition with a low effective radiation dose may serve as a valuable, low-radiation screening tool in the selection of patients for further, higher-dose UHR PCD-CT screening. |
| first_indexed | 2024-03-12T02:13:10Z |
| format | Article |
| id | doaj.art-6f6441f468c34d7f85d68efd10b0af7e |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:13:10Z |
| publishDate | 2023-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-6f6441f468c34d7f85d68efd10b0af7e2023-09-06T11:54:11ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122023-03-0129229129910.4274/dir.2023.22195913049054Photon-counting computed tomography in the assessment of rheumatoid arthritis-associated interstitial lung disease: an initial experienceNikolett Marton0Janos Gyebnar1Kinga Fritsch2Judit Majnik3Gyorgy Nagy4Judit Simon5Veronika Müller6Adam Domonkos Tarnoki7David Laszlo Tarnoki8Pal Maurovich-Horvat9 Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary Department of Rheumatology, Buda Hospital of the Hospitaller Order of Saint John of God, Budapest, Hungary Department of Rheumatology, Buda Hospital of the Hospitaller Order of Saint John of God, Budapest, Hungary Department of Rheumatology, Buda Hospital of the Hospitaller Order of Saint John of God, Budapest, Hungary Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary Department of Pulmonology, Semmelweis University, Budapest, Hungary Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary PURPOSEInterstitial lung disease (ILD) accounts for a significant proportion of mortality and morbidity in patients with rheumatoid arthritis (RA). The aim of this cross-sectional study is to evaluate the performance of novel photon-counting detector computed tomography (PCD-CT) in the detection of pulmonary parenchymal involvement.METHODSSixty-one patients with RA without a previous definitive diagnosis of ILD underwent high-resolution (HR) (0.4 mm slice thickness) and ultra-high-resolution (UHR) (0.2 mm slice thickness) PCDCT examination. The extent of interstitial abnormalities [ground-glass opacity (GGO), reticulation, bronchiectasis, and honeycombing] were scored in each lobe using a Likert-type scale. Total ILD scores were calculated as the sum of scores from all lobes.RESULTSReticulation and bronchiectasis scores were higher in the UHR measurements taken compared with the HR protocol [median (quartile 1, quartile 3): 2 (0, 3.5) vs. 0 (0, 3), P < 0.001 and 2 (0, 2) vs. 0 (0, 2), P < 0.001, respectively]; however, GGO and honeycombing scores did not differ [2 (2, 4) vs. 2 (2, 4), P = 0.944 and 0 (0, 0) vs. 0 (0, 0), P = 0.641, respectively]. Total ILD scores from both HR and UHR scans showed a mild negative correlation in diffusion capacity for carbon monoxide (HR: r = –0.297, P = 0.034; UHR: r = –0.294, P = 0.036). The pattern of lung parenchymal involvement did not differ significantly between the two protocols. The HR protocol had significantly lower volume CT dose index [0.67 (0.69, 1.06) mGy], total dose length product [29 (24.48, 33.2) mGy*cm] compared with UHR scans [8.18 (6.80, 9.23) mGy, P < 0.001 and 250 (218, 305) mGy*cm, P < 0.001].CONCLUSIONUHR PCD-CT provides more detailed information on ILD in patients with RA than low-dose HR PCDCT. HR PCD-CT image acquisition with a low effective radiation dose may serve as a valuable, low-radiation screening tool in the selection of patients for further, higher-dose UHR PCD-CT screening. http://www.dirjournal.org/archives/archive-detail/article-preview/photon-counting-computed-tomography-in-the-assessm/58822 cthigh-resolutionlow-doselungphoton-countingultra-high-resolution |
| spellingShingle | Nikolett Marton Janos Gyebnar Kinga Fritsch Judit Majnik Gyorgy Nagy Judit Simon Veronika Müller Adam Domonkos Tarnoki David Laszlo Tarnoki Pal Maurovich-Horvat Photon-counting computed tomography in the assessment of rheumatoid arthritis-associated interstitial lung disease: an initial experience Diagnostic and Interventional Radiology ct high-resolution low-dose lung photon-counting ultra-high-resolution |
| title | Photon-counting computed tomography in the assessment of rheumatoid arthritis-associated interstitial lung disease: an initial experience |
| title_full | Photon-counting computed tomography in the assessment of rheumatoid arthritis-associated interstitial lung disease: an initial experience |
| title_fullStr | Photon-counting computed tomography in the assessment of rheumatoid arthritis-associated interstitial lung disease: an initial experience |
| title_full_unstemmed | Photon-counting computed tomography in the assessment of rheumatoid arthritis-associated interstitial lung disease: an initial experience |
| title_short | Photon-counting computed tomography in the assessment of rheumatoid arthritis-associated interstitial lung disease: an initial experience |
| title_sort | photon counting computed tomography in the assessment of rheumatoid arthritis associated interstitial lung disease an initial experience |
| topic | ct high-resolution low-dose lung photon-counting ultra-high-resolution |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/photon-counting-computed-tomography-in-the-assessm/58822
|
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