TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer

TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer

Abstract Induction of tumor vascular normalization is a crucial measure to enhance immunotherapy efficacy. cGAS-STING pathway is vital for anti-tumor immunity, but its role in tumor vasculature is unclear. Herein, using preclinical liver cancer models in Cgas/Sting-deficient male mice, we report tha...

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Bibliographic Details
Main Authors: Hongwei Lv, Qianni Zong, Cian Chen, Guishuai Lv, Wei Xiang, Fuxue Xing, Guoqing Jiang, Bing Yan, Xiaoyan Sun, Yue Ma, Liang Wang, Zixin Wu, Xiuliang Cui, Hongyang Wang, Wen Yang
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43743-9

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https://doi.org/10.1038/s41467-023-43743-9

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