Synthesis and Characterization of Agarose Hydrogels for Release of Diclofenac Sodium
Hydrogels are attractive biomaterials for the controlled release of various pharmaceuticals, due to their ability to embed biologically active moieties in a 3D polymer network. Among them, agarose-based hydrogels are an interesting, but still not fully explored, group of potential platforms for cont...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/16/17/6042 |
| _version_ | 1797582192225812480 |
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| author | Anna Jarosz Oliwia Kapusta Dorota Gugała-Fekner Mariusz Barczak |
| author_facet | Anna Jarosz Oliwia Kapusta Dorota Gugała-Fekner Mariusz Barczak |
| author_sort | Anna Jarosz |
| collection | DOAJ |
| description | Hydrogels are attractive biomaterials for the controlled release of various pharmaceuticals, due to their ability to embed biologically active moieties in a 3D polymer network. Among them, agarose-based hydrogels are an interesting, but still not fully explored, group of potential platforms for controlled drug release. In this work, agarose hydrogels with various contents of citric acid were prepared, and their mechanical and physicochemical properties were investigated using various instrumental techniques, such as rheological measurements, attenuated total reflection–Fourier transform infrared spectroscopy (ATR-FTIR). Releasing tests for diclofenac sodium (DICL) were run in various environments; water, PBS, and 0.01 M NaOH; which remarkably affected the profile of the controlled release of this model drug. In addition to affecting the mechanical properties, the amount of citric acid incorporated within a hydrogel network during synthesis was also of great importance to the rate of DICL release. Therefore, due to their high biocompatibility, agarose hydrogels can be regarded as safe and potential platforms for controlled drug release in biomedical applications. |
| first_indexed | 2024-03-10T23:18:28Z |
| format | Article |
| id | doaj.art-6f669600597c4adfbf438e0f8987d36e |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T23:18:28Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
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| series | Materials |
| spelling | doaj.art-6f669600597c4adfbf438e0f8987d36e2023-11-19T08:29:27ZengMDPI AGMaterials1996-19442023-09-011617604210.3390/ma16176042Synthesis and Characterization of Agarose Hydrogels for Release of Diclofenac SodiumAnna Jarosz0Oliwia Kapusta1Dorota Gugała-Fekner2Mariusz Barczak3Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Sklodowska University, Maria Curie-Sklodowska Sq. 3, 20-031 Lublin, PolandFaculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Sklodowska University, Maria Curie-Sklodowska Sq. 3, 20-031 Lublin, PolandFaculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Sklodowska University, Maria Curie-Sklodowska Sq. 3, 20-031 Lublin, PolandFaculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Sklodowska University, Maria Curie-Sklodowska Sq. 3, 20-031 Lublin, PolandHydrogels are attractive biomaterials for the controlled release of various pharmaceuticals, due to their ability to embed biologically active moieties in a 3D polymer network. Among them, agarose-based hydrogels are an interesting, but still not fully explored, group of potential platforms for controlled drug release. In this work, agarose hydrogels with various contents of citric acid were prepared, and their mechanical and physicochemical properties were investigated using various instrumental techniques, such as rheological measurements, attenuated total reflection–Fourier transform infrared spectroscopy (ATR-FTIR). Releasing tests for diclofenac sodium (DICL) were run in various environments; water, PBS, and 0.01 M NaOH; which remarkably affected the profile of the controlled release of this model drug. In addition to affecting the mechanical properties, the amount of citric acid incorporated within a hydrogel network during synthesis was also of great importance to the rate of DICL release. Therefore, due to their high biocompatibility, agarose hydrogels can be regarded as safe and potential platforms for controlled drug release in biomedical applications.https://www.mdpi.com/1996-1944/16/17/6042agarosehydrogelcontrolled releasedrug releasediclofenac sodium |
| spellingShingle | Anna Jarosz Oliwia Kapusta Dorota Gugała-Fekner Mariusz Barczak Synthesis and Characterization of Agarose Hydrogels for Release of Diclofenac Sodium Materials agarose hydrogel controlled release drug release diclofenac sodium |
| title | Synthesis and Characterization of Agarose Hydrogels for Release of Diclofenac Sodium |
| title_full | Synthesis and Characterization of Agarose Hydrogels for Release of Diclofenac Sodium |
| title_fullStr | Synthesis and Characterization of Agarose Hydrogels for Release of Diclofenac Sodium |
| title_full_unstemmed | Synthesis and Characterization of Agarose Hydrogels for Release of Diclofenac Sodium |
| title_short | Synthesis and Characterization of Agarose Hydrogels for Release of Diclofenac Sodium |
| title_sort | synthesis and characterization of agarose hydrogels for release of diclofenac sodium |
| topic | agarose hydrogel controlled release drug release diclofenac sodium |
| url | https://www.mdpi.com/1996-1944/16/17/6042 |
| work_keys_str_mv | AT annajarosz synthesisandcharacterizationofagarosehydrogelsforreleaseofdiclofenacsodium AT oliwiakapusta synthesisandcharacterizationofagarosehydrogelsforreleaseofdiclofenacsodium AT dorotagugałafekner synthesisandcharacterizationofagarosehydrogelsforreleaseofdiclofenacsodium AT mariuszbarczak synthesisandcharacterizationofagarosehydrogelsforreleaseofdiclofenacsodium |