The repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography
Abstract Background To investigate the repeatability of superficial retinal vessel density measurements in healthy eyes with long axial length (AL) using optical coherence tomography angiography (OCTA). Methods There were 60 eyes of 31 volunteers enrolled in this cross-sectional observational study....
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BMC
2018-12-01
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| Series: | BMC Ophthalmology |
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| Online Access: | http://link.springer.com/article/10.1186/s12886-018-0992-y |
| _version_ | 1818132494090764288 |
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| author | Mengyang Li Enzhong Jin Chongya Dong Chuan Zhang Mingwei Zhao Jinfeng Qu |
| author_facet | Mengyang Li Enzhong Jin Chongya Dong Chuan Zhang Mingwei Zhao Jinfeng Qu |
| author_sort | Mengyang Li |
| collection | DOAJ |
| description | Abstract Background To investigate the repeatability of superficial retinal vessel density measurements in healthy eyes with long axial length (AL) using optical coherence tomography angiography (OCTA). Methods There were 60 eyes of 31 volunteers enrolled in this cross-sectional observational study. All subjects underwent OCTA, AL and refraction test. The enrolled eyes were divided into the long AL group (26 mm ≤ AL < 28 mm) and normal AL group (22 mm ≤ AL < 26 mm). The vessel length density (VLD), perfusion density (PD), and fovea avascular zone (FAZ) of the superficial retinal vessel were evaluated. Repeatability was assessed by intraclass correlation coefficients (ICCs) and Bland-Altman analysis. Pearson’s r correlation was used to analyze the relation of AL and the absolute difference between two measurements. Results The 3 × 3 mm scan pattern showed good repeatability with all ICCs over 0.7. For all parameters of all scan patterns, the ICCs of the normal AL group were distinctly higher than those of the long AL group; this finding was also confirmed by Bland-Altman analysis. The correlation analysis of AL and repeatability of OCTA parameters showed significant negative correlations between the ALs and repeatability of VLD in 6 × 6 mm inner ring (r 2 = 0.13, p = 0.01), VLD in 6 × 6 mm outer ring (r 2 = 0.09, p = 0.02) and PD in 6 × 6 mm outer ring (r 2 = 0.08, p = 0.03). Conclusions The AL and the scanned area will both affect the repeatability of superficial retinal vessel density measurements in OCTA. |
| first_indexed | 2024-12-11T08:37:43Z |
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| id | doaj.art-6f66b6e8390747f1bf838ca1e603a4fe |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-11T08:37:43Z |
| publishDate | 2018-12-01 |
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| series | BMC Ophthalmology |
| spelling | doaj.art-6f66b6e8390747f1bf838ca1e603a4fe2022-12-22T01:14:19ZengBMCBMC Ophthalmology1471-24152018-12-011811710.1186/s12886-018-0992-yThe repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiographyMengyang Li0Enzhong Jin1Chongya Dong2Chuan Zhang3Mingwei Zhao4Jinfeng Qu5Department of Ophthalmology, Peking University People’s Hospital; Eye diseases and optometry Institute; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science CenterDepartment of Ophthalmology, Peking University People’s Hospital; Eye diseases and optometry Institute; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science CenterPeking University First HospitalDepartment of Ophthalmology, Peking University People’s Hospital; Eye diseases and optometry Institute; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science CenterDepartment of Ophthalmology, Peking University People’s Hospital; Eye diseases and optometry Institute; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science CenterDepartment of Ophthalmology, Peking University People’s Hospital; Eye diseases and optometry Institute; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science CenterAbstract Background To investigate the repeatability of superficial retinal vessel density measurements in healthy eyes with long axial length (AL) using optical coherence tomography angiography (OCTA). Methods There were 60 eyes of 31 volunteers enrolled in this cross-sectional observational study. All subjects underwent OCTA, AL and refraction test. The enrolled eyes were divided into the long AL group (26 mm ≤ AL < 28 mm) and normal AL group (22 mm ≤ AL < 26 mm). The vessel length density (VLD), perfusion density (PD), and fovea avascular zone (FAZ) of the superficial retinal vessel were evaluated. Repeatability was assessed by intraclass correlation coefficients (ICCs) and Bland-Altman analysis. Pearson’s r correlation was used to analyze the relation of AL and the absolute difference between two measurements. Results The 3 × 3 mm scan pattern showed good repeatability with all ICCs over 0.7. For all parameters of all scan patterns, the ICCs of the normal AL group were distinctly higher than those of the long AL group; this finding was also confirmed by Bland-Altman analysis. The correlation analysis of AL and repeatability of OCTA parameters showed significant negative correlations between the ALs and repeatability of VLD in 6 × 6 mm inner ring (r 2 = 0.13, p = 0.01), VLD in 6 × 6 mm outer ring (r 2 = 0.09, p = 0.02) and PD in 6 × 6 mm outer ring (r 2 = 0.08, p = 0.03). Conclusions The AL and the scanned area will both affect the repeatability of superficial retinal vessel density measurements in OCTA.http://link.springer.com/article/10.1186/s12886-018-0992-yOptical coherence tomography angiographyMyopiaVessel length densityPerfusion densityFovea avascular zoneRepeatability |
| spellingShingle | Mengyang Li Enzhong Jin Chongya Dong Chuan Zhang Mingwei Zhao Jinfeng Qu The repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography BMC Ophthalmology Optical coherence tomography angiography Myopia Vessel length density Perfusion density Fovea avascular zone Repeatability |
| title | The repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography |
| title_full | The repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography |
| title_fullStr | The repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography |
| title_full_unstemmed | The repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography |
| title_short | The repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography |
| title_sort | repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography |
| topic | Optical coherence tomography angiography Myopia Vessel length density Perfusion density Fovea avascular zone Repeatability |
| url | http://link.springer.com/article/10.1186/s12886-018-0992-y |
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