Mechanism of carcinogenesis after exposure of actinide radionuclides: Emerging concepts and missing links
Radiation carcinogenesis may be associated with external and/or internal sources of radiation exposure during accidental, occupational, or diagnostic/therapeutic conditions. Most of the radiation carcinogenic events are established after acute doses of low linear energy transfer external radiation....
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
|
| Series: | Journal of Radiation and Cancer Research |
| Subjects: | |
| Online Access: | http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=1;spage=20;epage=34;aulast=Yadav |
| _version_ | 1818494879060197376 |
|---|---|
| author | Rakhee Yadav Manjoor Ali Amit Kumar Badri N Pandey |
| author_facet | Rakhee Yadav Manjoor Ali Amit Kumar Badri N Pandey |
| author_sort | Rakhee Yadav |
| collection | DOAJ |
| description | Radiation carcinogenesis may be associated with external and/or internal sources of radiation exposure during accidental, occupational, or diagnostic/therapeutic conditions. Most of the radiation carcinogenic events are established after acute doses of low linear energy transfer external radiation. Moreover, the carcinogenic effects of internalized radioisotopes are also reported at their acute/chronic doses. In this regard, actinide radionuclides (like 238U, 239Pu, 232Th, and 241Am) are of great importance as fuel material or waste generated during nuclear power production. These radionuclides may result in incidence of cancer when internalized at high doses while accidental or occupation exposure. Even though the basic carcinogenic mechanism after external or internal radiation exposure remains the same, the magnitude of systemic or target specific radiation effects may vary in these radiation exposure conditions. The majority of the studies investigating biological, carcinogenic, and other health effects of actinide radionuclides are limited only up to quantification of these effects without much mechanistic insights. Moreover, the radiobiological processes, such as bystander effect, genomic instability, and adaptive response, governing the cellular radiosensitivity of targeted/nontargeted cells also need to be studied in the context of carcinogenesis after actinide radionuclides internalization. The review aims to highlight the emerging radiobiological concepts and missing links about actinide radionuclides-induced carcinogenesis. In addition, an overview has been presented about biological and health effects of major actinide radionuclides. |
| first_indexed | 2024-12-10T18:12:48Z |
| format | Article |
| id | doaj.art-6f67f75575634f7dba279b9713a1d090 |
| institution | Directory Open Access Journal |
| issn | 2588-9273 2468-9203 |
| language | English |
| last_indexed | 2024-12-10T18:12:48Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Radiation and Cancer Research |
| spelling | doaj.art-6f67f75575634f7dba279b9713a1d0902022-12-22T01:38:24ZengWolters Kluwer Medknow PublicationsJournal of Radiation and Cancer Research2588-92732468-92032017-01-0181203410.4103/0973-0168.199304Mechanism of carcinogenesis after exposure of actinide radionuclides: Emerging concepts and missing linksRakhee YadavManjoor AliAmit KumarBadri N PandeyRadiation carcinogenesis may be associated with external and/or internal sources of radiation exposure during accidental, occupational, or diagnostic/therapeutic conditions. Most of the radiation carcinogenic events are established after acute doses of low linear energy transfer external radiation. Moreover, the carcinogenic effects of internalized radioisotopes are also reported at their acute/chronic doses. In this regard, actinide radionuclides (like 238U, 239Pu, 232Th, and 241Am) are of great importance as fuel material or waste generated during nuclear power production. These radionuclides may result in incidence of cancer when internalized at high doses while accidental or occupation exposure. Even though the basic carcinogenic mechanism after external or internal radiation exposure remains the same, the magnitude of systemic or target specific radiation effects may vary in these radiation exposure conditions. The majority of the studies investigating biological, carcinogenic, and other health effects of actinide radionuclides are limited only up to quantification of these effects without much mechanistic insights. Moreover, the radiobiological processes, such as bystander effect, genomic instability, and adaptive response, governing the cellular radiosensitivity of targeted/nontargeted cells also need to be studied in the context of carcinogenesis after actinide radionuclides internalization. The review aims to highlight the emerging radiobiological concepts and missing links about actinide radionuclides-induced carcinogenesis. In addition, an overview has been presented about biological and health effects of major actinide radionuclides.http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=1;spage=20;epage=34;aulast=YadavActinide radionuclideschemical toxicity of actinide radionuclidesnontargeted radiation effectsradiation carcinogenesisradiation-induced bystander effect |
| spellingShingle | Rakhee Yadav Manjoor Ali Amit Kumar Badri N Pandey Mechanism of carcinogenesis after exposure of actinide radionuclides: Emerging concepts and missing links Journal of Radiation and Cancer Research Actinide radionuclides chemical toxicity of actinide radionuclides nontargeted radiation effects radiation carcinogenesis radiation-induced bystander effect |
| title | Mechanism of carcinogenesis after exposure of actinide radionuclides: Emerging concepts and missing links |
| title_full | Mechanism of carcinogenesis after exposure of actinide radionuclides: Emerging concepts and missing links |
| title_fullStr | Mechanism of carcinogenesis after exposure of actinide radionuclides: Emerging concepts and missing links |
| title_full_unstemmed | Mechanism of carcinogenesis after exposure of actinide radionuclides: Emerging concepts and missing links |
| title_short | Mechanism of carcinogenesis after exposure of actinide radionuclides: Emerging concepts and missing links |
| title_sort | mechanism of carcinogenesis after exposure of actinide radionuclides emerging concepts and missing links |
| topic | Actinide radionuclides chemical toxicity of actinide radionuclides nontargeted radiation effects radiation carcinogenesis radiation-induced bystander effect |
| url | http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=1;spage=20;epage=34;aulast=Yadav |
| work_keys_str_mv | AT rakheeyadav mechanismofcarcinogenesisafterexposureofactinideradionuclidesemergingconceptsandmissinglinks AT manjoorali mechanismofcarcinogenesisafterexposureofactinideradionuclidesemergingconceptsandmissinglinks AT amitkumar mechanismofcarcinogenesisafterexposureofactinideradionuclidesemergingconceptsandmissinglinks AT badrinpandey mechanismofcarcinogenesisafterexposureofactinideradionuclidesemergingconceptsandmissinglinks |