Infant mortality in twin pregnancies following in-utero demise of the co-twin
Objective: To assess whether conversion from twin to singleton pregnancy following the demise of a co-twin influences survival. Methods: This retrospective study compared the risk for neonatal, post-neonatal and infant death for converted co-twins versus unconverted co-twins using the US matched mul...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-09-01
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| Series: | Asian Pacific Journal of Reproduction |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S230505001500010X |
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| author | Boubakari Ibrahimou Hamisu M. Salihu Muktar H. Aliyu Gary English Getachew Dagne |
| author_facet | Boubakari Ibrahimou Hamisu M. Salihu Muktar H. Aliyu Gary English Getachew Dagne |
| author_sort | Boubakari Ibrahimou |
| collection | DOAJ |
| description | Objective: To assess whether conversion from twin to singleton pregnancy following the demise of a co-twin influences survival.
Methods: This retrospective study compared the risk for neonatal, post-neonatal and infant death for converted co-twins versus unconverted co-twins using the US matched multiple file dataset for the period 1995–2000. We also examined the same risks for converted versus same-quantile co-twins, hazard ratios (HR) and 95% confidence intervals (CI) were computed using Cox Proportional Hazards models.
Results: The risk for neonatal (HR = 0.18, 95% CI: 0.09–0.34 and HR = 0.69, 95% CI: 0.50–0.96) and infant death (HR = 0.22, 95% CI: 0.12–0.42 and HR = 0.57, 95% CI: 0.42–0.77) were significantly lower for converted twins than for unconverted twins and same-quantile twins, respectively. For black compared to white, the risk for post-neonatal death increased by 89% (HR = 1.89, 95% CI = 1.03, 3.48), and 79% (HR = 1.79, 95% CI = 1.53, 2.09) for converted vs. unconverted and converted vs. same-quantile, respectively. For converted black, the risk for neonatal death decreased by 17% (HR = 0.83, 95% CI = 0.73–0.93) as compared to unconverted.
Conclusions: Risks for all mortality types were lower among converted co-twins than their unconverted or same-quantile counterparts. The lower neonatal and higher post-neonatal mortality among black require future research. |
| first_indexed | 2024-12-23T05:28:03Z |
| format | Article |
| id | doaj.art-6f681c675a8444708ce4eb3b431c6ffe |
| institution | Directory Open Access Journal |
| issn | 2305-0500 |
| language | English |
| last_indexed | 2024-12-23T05:28:03Z |
| publishDate | 2015-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Reproduction |
| spelling | doaj.art-6f681c675a8444708ce4eb3b431c6ffe2022-12-21T17:58:33ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Reproduction2305-05002015-09-014322823410.1016/j.apjr.2015.06.007Infant mortality in twin pregnancies following in-utero demise of the co-twinBoubakari Ibrahimou0Hamisu M. Salihu1Muktar H. Aliyu2Gary English3Getachew Dagne4Florida International University, Robert Stempel College of Public Health & Social Work, Department of Biostatistics, 11200 S.W. 8th Street, AHC2 583, Miami, FL 33199, USABaylor College of Medicine, Department of Family and Community Medicine, 3701 Kirby Drive, Suite 600, Houston, TX 77098, USADepartment of Health Policy, Vanderbilt University, 2525 West End Avenue, Suite 750, Nashville, TN 37203, USAWestern Kentucky University, College of Health and Human Services, Department of Public Health, 1906 College Heights Blvd., Bowling Green, KY 42101, USAUniversity of South Florida, College of Public Health, Department of Epidemiology and Biostatistics, 13201 Bruce B. Downs Blvd., MDC 56, Tampa, FL 33612, USAObjective: To assess whether conversion from twin to singleton pregnancy following the demise of a co-twin influences survival. Methods: This retrospective study compared the risk for neonatal, post-neonatal and infant death for converted co-twins versus unconverted co-twins using the US matched multiple file dataset for the period 1995–2000. We also examined the same risks for converted versus same-quantile co-twins, hazard ratios (HR) and 95% confidence intervals (CI) were computed using Cox Proportional Hazards models. Results: The risk for neonatal (HR = 0.18, 95% CI: 0.09–0.34 and HR = 0.69, 95% CI: 0.50–0.96) and infant death (HR = 0.22, 95% CI: 0.12–0.42 and HR = 0.57, 95% CI: 0.42–0.77) were significantly lower for converted twins than for unconverted twins and same-quantile twins, respectively. For black compared to white, the risk for post-neonatal death increased by 89% (HR = 1.89, 95% CI = 1.03, 3.48), and 79% (HR = 1.79, 95% CI = 1.53, 2.09) for converted vs. unconverted and converted vs. same-quantile, respectively. For converted black, the risk for neonatal death decreased by 17% (HR = 0.83, 95% CI = 0.73–0.93) as compared to unconverted. Conclusions: Risks for all mortality types were lower among converted co-twins than their unconverted or same-quantile counterparts. The lower neonatal and higher post-neonatal mortality among black require future research.http://www.sciencedirect.com/science/article/pii/S230505001500010XSurviving co-twinDouble programmingTwin conversionTwin pregnancyMortality |
| spellingShingle | Boubakari Ibrahimou Hamisu M. Salihu Muktar H. Aliyu Gary English Getachew Dagne Infant mortality in twin pregnancies following in-utero demise of the co-twin Asian Pacific Journal of Reproduction Surviving co-twin Double programming Twin conversion Twin pregnancy Mortality |
| title | Infant mortality in twin pregnancies following in-utero demise of the co-twin |
| title_full | Infant mortality in twin pregnancies following in-utero demise of the co-twin |
| title_fullStr | Infant mortality in twin pregnancies following in-utero demise of the co-twin |
| title_full_unstemmed | Infant mortality in twin pregnancies following in-utero demise of the co-twin |
| title_short | Infant mortality in twin pregnancies following in-utero demise of the co-twin |
| title_sort | infant mortality in twin pregnancies following in utero demise of the co twin |
| topic | Surviving co-twin Double programming Twin conversion Twin pregnancy Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S230505001500010X |
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