The mechanisms and functions of TNF-α in intervertebral disc degeneration
Low back pain (LBP) is one of the most common health problems in people's lives, which brings a massive burden to clinicians, and the leading cause of LBP is intervertebral disc degeneration (IDD). IDD is mainly caused by factors such as aging, mechanical stress, and lack of nutrition. The path...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Experimental Gerontology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556523000402 |
| _version_ | 1797776173424443392 |
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| author | Hongyu Pan Hongtao Li Sheng Guo Chenglong Wang Longhai Long Xiaoqiang Wang Houyin Shi Kaiquan Zhang Hui Chen Sen Li |
| author_facet | Hongyu Pan Hongtao Li Sheng Guo Chenglong Wang Longhai Long Xiaoqiang Wang Houyin Shi Kaiquan Zhang Hui Chen Sen Li |
| author_sort | Hongyu Pan |
| collection | DOAJ |
| description | Low back pain (LBP) is one of the most common health problems in people's lives, which brings a massive burden to clinicians, and the leading cause of LBP is intervertebral disc degeneration (IDD). IDD is mainly caused by factors such as aging, mechanical stress, and lack of nutrition. The pathological mechanism of IDD is very complex, involving inflammatory response, cell metabolism disorder, and so on. Unfortunately, in the current treatment of IDD, only relieving symptoms as the primary means of relieving a patient's pain cannot effectively inhibit or reverse the progression of IDD. Tumor necrosis factor-α (TNF-α) is a multifunctional pro-inflammatory factor involved in many diseases' pathological processes. With the in-depth study of the pathological mechanism of IDD, more and more evidence has shown that TNF-α is an essential activator of IDD, which is related to the metabolic disorder, inflammatory responses, apoptosis, and other pathological processes of extracellular dissociation in the intervertebral disc. Therefore, anti-TNF-α therapy is an effective therapeutic target for alleviating IDD, especially in inhibiting extracellular matrix degradation and reducing inflammatory responses. This article reviews the pathological role of TNF-α in IDD and the latest research progress of TNF-α inhibitors in treating IDD. |
| first_indexed | 2024-03-12T22:47:14Z |
| format | Article |
| id | doaj.art-6f684a334c594277bd9ab7fdf258568d |
| institution | Directory Open Access Journal |
| issn | 1873-6815 |
| language | English |
| last_indexed | 2024-03-12T22:47:14Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj.art-6f684a334c594277bd9ab7fdf258568d2023-07-21T04:58:55ZengElsevierExperimental Gerontology1873-68152023-04-01174112119The mechanisms and functions of TNF-α in intervertebral disc degenerationHongyu Pan0Hongtao Li1Sheng Guo2Chenglong Wang3Longhai Long4Xiaoqiang Wang5Houyin Shi6Kaiquan Zhang7Hui Chen8Sen Li9Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaCorrespondence to: H. Chen, Department of Geriatric, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China.; Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaCorresponding author.; Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaLow back pain (LBP) is one of the most common health problems in people's lives, which brings a massive burden to clinicians, and the leading cause of LBP is intervertebral disc degeneration (IDD). IDD is mainly caused by factors such as aging, mechanical stress, and lack of nutrition. The pathological mechanism of IDD is very complex, involving inflammatory response, cell metabolism disorder, and so on. Unfortunately, in the current treatment of IDD, only relieving symptoms as the primary means of relieving a patient's pain cannot effectively inhibit or reverse the progression of IDD. Tumor necrosis factor-α (TNF-α) is a multifunctional pro-inflammatory factor involved in many diseases' pathological processes. With the in-depth study of the pathological mechanism of IDD, more and more evidence has shown that TNF-α is an essential activator of IDD, which is related to the metabolic disorder, inflammatory responses, apoptosis, and other pathological processes of extracellular dissociation in the intervertebral disc. Therefore, anti-TNF-α therapy is an effective therapeutic target for alleviating IDD, especially in inhibiting extracellular matrix degradation and reducing inflammatory responses. This article reviews the pathological role of TNF-α in IDD and the latest research progress of TNF-α inhibitors in treating IDD.http://www.sciencedirect.com/science/article/pii/S0531556523000402TNF-αIntervertebral disc degenerationInflammatory responsePro-inflammatory factor |
| spellingShingle | Hongyu Pan Hongtao Li Sheng Guo Chenglong Wang Longhai Long Xiaoqiang Wang Houyin Shi Kaiquan Zhang Hui Chen Sen Li The mechanisms and functions of TNF-α in intervertebral disc degeneration Experimental Gerontology TNF-α Intervertebral disc degeneration Inflammatory response Pro-inflammatory factor |
| title | The mechanisms and functions of TNF-α in intervertebral disc degeneration |
| title_full | The mechanisms and functions of TNF-α in intervertebral disc degeneration |
| title_fullStr | The mechanisms and functions of TNF-α in intervertebral disc degeneration |
| title_full_unstemmed | The mechanisms and functions of TNF-α in intervertebral disc degeneration |
| title_short | The mechanisms and functions of TNF-α in intervertebral disc degeneration |
| title_sort | mechanisms and functions of tnf α in intervertebral disc degeneration |
| topic | TNF-α Intervertebral disc degeneration Inflammatory response Pro-inflammatory factor |
| url | http://www.sciencedirect.com/science/article/pii/S0531556523000402 |
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