An NMR Study on Hydration and Molecular Interaction of Phytantriol-Based Liquid Crystals
Phytantriol-based lyotropic liquid crystals (LLCs) have emerged as a new nanodrug delivery system. However, the understanding of phytantriol-based LLCs is lacking. In this study, we use NMR technology to characterize LLC formation over two months. Three samples in different phases were prepared with...
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MDPI AG
2022-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/11/2312 |
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| author | Yu Lu Di Zhu Quynh Le Yuji Wang Wei Wang |
| author_facet | Yu Lu Di Zhu Quynh Le Yuji Wang Wei Wang |
| author_sort | Yu Lu |
| collection | DOAJ |
| description | Phytantriol-based lyotropic liquid crystals (LLCs) have emerged as a new nanodrug delivery system. However, the understanding of phytantriol-based LLCs is lacking. In this study, we use NMR technology to characterize LLC formation over two months. Three samples in different phases were prepared with different hydration states. NMR data, including 1D-<sup>1</sup>H, <sup>13</sup>C-{<sup>1</sup>H}, 2D-HSQC, HMBC, COSY, NOESY, etc., were collected. A comprehensive analysis of these NMR data was performed on the three phases of phytantriol-based LLCs. The following results were achieved from the study. First, the <sup>1</sup>H and <sup>13</sup>C-{<sup>1</sup>H} spectra of phytantriol were assigned. Second, the change of NMR spectra during the formation of the phases was observed, and the change of hydration was calculated for the time-dependent phase formation. Third, the correlation peaks of 2D-NOESY were used to describe the spatial relationship of lipids–water interaction and lipid–lipid interaction. |
| first_indexed | 2024-03-09T18:45:04Z |
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| id | doaj.art-6f69ea9c43764c4ea22970ee3f98cec4 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T18:45:04Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj.art-6f69ea9c43764c4ea22970ee3f98cec42023-11-24T06:20:08ZengMDPI AGPharmaceutics1999-49232022-10-011411231210.3390/pharmaceutics14112312An NMR Study on Hydration and Molecular Interaction of Phytantriol-Based Liquid CrystalsYu Lu0Di Zhu1Quynh Le2Yuji Wang3Wei Wang4Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, ChinaDepartment of Medicinal Chemistry, College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, ChinaCenter for Pharmacy, University of Bergen, P.O. Box 7803, 5020 Bergen, NorwayDepartment of Medicinal Chemistry, College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, ChinaDepartment of Chemistry, University of Bergen, P.O. Box 7803, 5020 Bergen, NorwayPhytantriol-based lyotropic liquid crystals (LLCs) have emerged as a new nanodrug delivery system. However, the understanding of phytantriol-based LLCs is lacking. In this study, we use NMR technology to characterize LLC formation over two months. Three samples in different phases were prepared with different hydration states. NMR data, including 1D-<sup>1</sup>H, <sup>13</sup>C-{<sup>1</sup>H}, 2D-HSQC, HMBC, COSY, NOESY, etc., were collected. A comprehensive analysis of these NMR data was performed on the three phases of phytantriol-based LLCs. The following results were achieved from the study. First, the <sup>1</sup>H and <sup>13</sup>C-{<sup>1</sup>H} spectra of phytantriol were assigned. Second, the change of NMR spectra during the formation of the phases was observed, and the change of hydration was calculated for the time-dependent phase formation. Third, the correlation peaks of 2D-NOESY were used to describe the spatial relationship of lipids–water interaction and lipid–lipid interaction.https://www.mdpi.com/1999-4923/14/11/2312phytantriolLLCsNMRNOESYhydrationmolecular interaction |
| spellingShingle | Yu Lu Di Zhu Quynh Le Yuji Wang Wei Wang An NMR Study on Hydration and Molecular Interaction of Phytantriol-Based Liquid Crystals Pharmaceutics phytantriol LLCs NMR NOESY hydration molecular interaction |
| title | An NMR Study on Hydration and Molecular Interaction of Phytantriol-Based Liquid Crystals |
| title_full | An NMR Study on Hydration and Molecular Interaction of Phytantriol-Based Liquid Crystals |
| title_fullStr | An NMR Study on Hydration and Molecular Interaction of Phytantriol-Based Liquid Crystals |
| title_full_unstemmed | An NMR Study on Hydration and Molecular Interaction of Phytantriol-Based Liquid Crystals |
| title_short | An NMR Study on Hydration and Molecular Interaction of Phytantriol-Based Liquid Crystals |
| title_sort | nmr study on hydration and molecular interaction of phytantriol based liquid crystals |
| topic | phytantriol LLCs NMR NOESY hydration molecular interaction |
| url | https://www.mdpi.com/1999-4923/14/11/2312 |
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